{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:37:09Z","timestamp":1778931429573,"version":"3.51.4"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":["eur j endocrinol"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>: Recent studies have indicated the existence of causal links between the endocrine and immune systems and cardiovascular disease. Mannan-binding lectin (MBL), a protein of the innate immune system, may constitute a connection between these fields.<\/jats:p>\n      <jats:p><jats:italic>Methods<\/jats:italic>: To test whether thyroid hormone regulates MBL levels, we studied eight patients with Graves\u2019 hyperthyroidism before and after methimazole therapy, eight healthy subjects before and after short-term experimental hyperthyroidism, and eight hypothyroid patients with chronic auto-immune thyroiditis before and after L-thyroxine substitution.<\/jats:p>\n      <jats:p><jats:italic>Results<\/jats:italic>: In all hyperthyroid patients, MBL levels were increased \u2013 median (range), 1886 ng\/ml (1478\u20137344) \u2013 before treatment and decreased to 954 ng\/ml (312\u20133222) after treatment (<jats:italic>P<\/jats:italic> = 0.01, paired comparison: Wilcoxon\u2019s signed ranks test). The healthy subjects had MBL levels of 1081 ng\/ml (312\u20131578). Administration of thyroid hormones to these persons induced mild hyperthyroidism and increased MBL levels significantly to 1714 ng\/ml (356\u20132488) (<jats:italic>P<\/jats:italic> = 0.01). Two of the eight hypothyroid patients had undetectably low levels of MBL both before and after L-thyroxine substitution. The other six hypothyroid patients had decreased levels of MBL of 145 ng\/ml (20\u2013457) compared with 979 ng\/ml (214\u20131533) after L-thyroxine substitution (<jats:italic>P<\/jats:italic> = 0.03, paired comparison: Wilcoxon\u2019s signed ranks test).<\/jats:p>\n      <jats:p><jats:italic>Conclusion<\/jats:italic>: Our data show that thyroid hormone increases levels of MBL. MBL is part of the inflammatory complement system, and this modulation of complement activation may play a role in the pathogenesis of a number of key components of thyroid diseases.<\/jats:p>","DOI":"10.1530\/eje.1.02013","type":"journal-article","created":{"date-parts":[[2005,10,31]],"date-time":"2005-10-31T07:57:42Z","timestamp":1130745462000},"page":"643-649","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":22,"title":["Thyroid hormone increases mannan-binding lectin levels"],"prefix":"10.1093","volume":"153","author":[{"given":"Anne Lene Dalkj\u00e6r","family":"Riis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troels Krarup","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Thiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus H\u00f8jbjerg","family":"Gravholt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Signe","family":"Gjedde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars Christian","family":"Gormsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens Otto Lunde","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen","family":"Weeke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/153\/5\/1530643.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/153\/5\/1530643.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:35:33Z","timestamp":1676392533000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/153\/5\/643\/6694626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":0,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.1530\/eje.1.02013","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}