{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:10:40Z","timestamp":1791943840709,"version":"4.3.4"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":["eur j endocrinol"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>: Patients with Cushing\u2019s disease have a high prevalence of atherosclerosis and maintain an increased cardiovascular risk even after cure of the disease. However, the impact of Cushing\u2019s disease on renal function remains to be quantified.<\/jats:p>\n      <jats:p><jats:italic>Objectives<\/jats:italic>: To evaluate glomerular filtration rate (GFR) and to identify predictors of GFR in patients with Cushing\u2019s disease.<\/jats:p>\n      <jats:p><jats:italic>Design and methods<\/jats:italic>: We conducted a matched case\u2013control study: 18 patients with active or cured Cushing\u2019s disease were compared with healthy population controls matched for age and sex. The main outcome measures were GFR and micro-albuminuria.<\/jats:p>\n      <jats:p><jats:italic>Results<\/jats:italic>: Patients with Cushing\u2019s disease had a lower GFR, as measured by 24-h creatinine clearance (79 versus 95 ml\/min per 1.73 m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic> = 0.005) and estimated by the MDRD<jats:sub>2<\/jats:sub> formula (75 versus 88 ml\/min per 1.73 m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic> = 0.008). Multiple regression analyses indicated that disease duration was the strongest predictor for a worse GFR. The prevalence of micro-albuminuria was low (5.5% in both groups).<\/jats:p>\n      <jats:p><jats:italic>Conclusions<\/jats:italic>: Patients with Cushing\u2019s disease have a decreased GFR. Even if they are cured, close follow-up with strict control of cardiovascular risk factors and monitoring of GFR seems mandatory. Furthermore, the dosage of certain drugs should be adapted to the individual GFR.<\/jats:p>","DOI":"10.1530\/eje.1.02040","type":"journal-article","created":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T19:47:04Z","timestamp":1133466424000},"page":"819-829","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":21,"title":["Glomerular filtration rate in patients with Cushing\u2019s disease: a matched case\u2013control study"],"prefix":"10.1093","volume":"153","author":[{"given":"P","family":"Haentjens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"De Meirleir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Abs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Verhelst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Poppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Velkeniers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/153\/6\/1530819.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/153\/6\/1530819.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:35:41Z","timestamp":1676392541000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/153\/6\/819\/6695209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1530\/eje.1.02040","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}