{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:52:23Z","timestamp":1790833943691,"version":"4.1.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":["eur j endocrinol"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>: Depot GnRH agonists are commonly used in the treatment of central precocious puberty (CPP). The triptorelin 11.25 mg 3-month depot, currently used in adult indications, had not previously been evaluated in CPP.<\/jats:p>\n      <jats:p><jats:italic>Design<\/jats:italic>: This was a multicenter, open-label, 12 month trial conducted in 64 CPP children (54 girls and 10 boys), treated quarterly.<\/jats:p>\n      <jats:p><jats:italic>Methods<\/jats:italic>: Children with a clinical onset of pubertal development before the age of 8 years (girls) or 9 years (boys), pubertal response of LH to GnRH \u22657 IU\/l, advanced bone age &gt;1 year, enlarged uterus (\u226536 mm) and testosterone level \u22650.5 ng\/ml (boys), were included. Suppression of gonadotropic activation, as determined from serum LH, FSH, estradiol or testosterone, and pubertal signs were assessed at Months 3, 6 and 12.<\/jats:p>\n      <jats:p><jats:italic>Results<\/jats:italic>: GnRH-stimulated peak LH \u22643 IU\/l, the main efficacy criterion, was met in 53 out of 62 (85%), 60 out of 62 (97%) and 56 out of 59 (95%) of the children at Months 3, 6 and 12 respectively. Serum FSH and sex steroids were also significantly reduced, while pubertal development regressed in most patients. Mean residual triptorelin levels were stable from Month 3 through to Month 12. The triptorelin 3-month depot was well tolerated. Severe injection pain was experienced in only one instance. Five girls experienced mild-to-moderate or severe (one girl) withdrawal bleeding.<\/jats:p>\n      <jats:p><jats:italic>Conclusions<\/jats:italic>: The triptorelin 3-month depot efficiently suppresses the pituitary\u2013gonadal axis and pubertal development in children with CPP. This formulation allows a 3-fold reduction, over the once-a-month depot, in the number of i.m. injections required each year.<\/jats:p>","DOI":"10.1530\/eje.1.02056","type":"journal-article","created":{"date-parts":[[2005,12,28]],"date-time":"2005-12-28T18:33:21Z","timestamp":1135794801000},"page":"119-124","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":49,"title":["Three-month sustained-release triptorelin (11.25 mg) in the treatment of central precocious puberty"],"prefix":"10.1093","volume":"154","author":[{"given":"Jean-Claude","family":"Carel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe\u0308lle","family":"Blumberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Seymour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Adamsbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najiba","family":"Lahlou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"1_26123257","first-page":"165","volume":"16","year":"2002","journal-title":"CLINICAL ENDOCRINOLOGY AND METABOLISM"},{"issue":"2","key":"2_9384368","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1056\/NEJM199101103240205","volume":"324","author":"Conn","year":"1991","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"2","key":"3_8299759","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1210\/jcem-52-2-370","volume":"52","author":"CROWLEY","year":"1981","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"26","key":"4_8542863","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1056\/NEJM198112243052602","volume":"305","author":"Comite","year":"1981","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"5","key":"5_5571261","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1007\/BF02171554","volume":"149","author":"Oostdijk","year":"1990","journal-title":"European journal of pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0340-6199","issn-type":"print"},{"issue":"6","key":"6_10856371","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1210\/jc.84.6.1973","volume":"84","author":"Carel","year":"1999","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"4","key":"7_13750257","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1210\/jcem-62-4-670","volume":"62","author":"ROGER","year":"1986","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3-4","key":"8_14542016","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000182709","volume":"39","author":"Partsch","year":"1993","journal-title":"Hormone research","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0163","issn-type":"print"},{"issue":"6","key":"9_15912785","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1530\/eje.0.1320699","volume":"132","author":"Carel","year":"1995","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"1","key":"10_9475675","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1210\/jcem-73-1-50","volume":"73","author":"PARKER","year":"1991","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"4","key":"11_9994549","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/S0022-3476(05)81162-X","volume":"121","author":"Neely","year":"1992","journal-title":"The Journal of pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3476","issn-type":"print"},{"issue":"10","key":"12_15751896","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1111\/j.1651-2227.1994.tb12984.x","volume":"83","author":"Antoniazzi","year":"1994","journal-title":"Acta paediatrica (Oslo, Norway : 1992)","ISSN":"https:\/\/id.crossref.org\/issn\/0365-1436","issn-type":"print"},{"issue":"2","key":"13_4958076","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1210\/jcem-67-2-368","volume":"67","author":"MANASCO","year":"1988","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"1","key":"14_9120636","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1159\/000073280","volume":"33","author":"Kauli","year":"1990","journal-title":"Hormone research","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0163","issn-type":"print"},{"key":"15_9605636","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1651-2227.1991.tb17967.x","volume":"372","author":"Oostdijk","year":"1991","journal-title":"Acta paediatrica Scandinavica. Supplement","ISSN":"https:\/\/id.crossref.org\/issn\/0300-8843","issn-type":"print"},{"issue":"9","key":"16_17225416","doi-asserted-by":"publisher","first-page":"4111","DOI":"10.1210\/jc.2001-020243","volume":"87","author":"Carel","year":"2002","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"2","key":"17_17176902","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1046\/j.1365-2265.2002.01571.x","volume":"57","author":"Trueman","year":"2002","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"2","key":"18_18129585","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1093\/humupd\/dmh012","volume":"10","author":"Carel","year":"2004","journal-title":"Human Reproduction Update","ISSN":"https:\/\/id.crossref.org\/issn\/1355-4786","issn-type":"print"},{"issue":"2","key":"19_18043460","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.fertnstert.2003.07.013","volume":"81","author":"Donnez","year":"2004","journal-title":"Fertility and sterility","ISSN":"https:\/\/id.crossref.org\/issn\/0015-0282","issn-type":"print"},{"issue":"2","key":"20_6116537","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000023241","volume":"50","author":"Bouchot","year":"1998","journal-title":"Hormone research","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0163","issn-type":"print"},{"issue":"3","key":"24_10237799","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1651-2227.1993.tb12656.x","volume":"82","author":"Saggese","year":"1993","journal-title":"Acta paediatrica (Oslo, Norway : 1992)","ISSN":"https:\/\/id.crossref.org\/issn\/0365-1436","issn-type":"print"},{"issue":"6","key":"25_15617201","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1651-2227.1994.tb13095.x","volume":"83","author":"Heinrichs","year":"1994","journal-title":"Acta paediatrica (Oslo, Norway : 1992)","ISSN":"https:\/\/id.crossref.org\/issn\/0365-1436","issn-type":"print"},{"issue":"2","key":"27_14409388","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0022-3476(05)81720-2","volume":"123","author":"Manasco","year":"1993","journal-title":"The Journal of pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3476","issn-type":"print"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/154\/1\/1540119.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/154\/1\/1540119.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:35:47Z","timestamp":1676392547000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/154\/1\/119\/6695543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":23,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/eje.1.02056","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}