{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:35:13Z","timestamp":1790832913691,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":["eur j endocrinol"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>: We aimed to assess possible genomic instability in women with polycystic ovary syndrome (PCOS).<\/jats:p>\n      <jats:p><jats:italic>Design<\/jats:italic>: The frequency of micronuclei in cultured peripheral lymphocytes was used as a biomarker of genomic instability in somatic cells.<\/jats:p>\n      <jats:p><jats:italic>Methods<\/jats:italic>: Nineteen women, diagnosed with PCOS and 19 healthy female volunteers of corresponding ages and body-mass index (BMI) were included in the study. Micronuclei frequencies were assessed in cytokinesis-blocked lymphocytes.<\/jats:p>\n      <jats:p><jats:italic>Results<\/jats:italic>: The frequency of micronucleated cells (per thousand) was 9.00 (5.00) (interquartile range in parentheses) for patient group and 3.0 (3.0) for the control group (<jats:italic>P<\/jats:italic> &lt; 0.0001, Mann-Whitney U-test). The serum levels of follicle-stimulating hormone (FSH), estradiol, prolactin, glucose and dehydroepiandrosterone sulfate (DHEAS) and the homeostasis model of assessment of insulin resistance (HOMA-IR) were not different between the two groups (<jats:italic>P<\/jats:italic> &gt; 0.05). Serum total testosterone, luteinizing hormone (LH) and insulin levels and hirsutism score in the PCOS group were significantly (<jats:italic>P<\/jats:italic> = 0.007, <jats:italic>P<\/jats:italic> &lt; 0.0001, <jats:italic>P<\/jats:italic> = 0.009 and <jats:italic>P<\/jats:italic> &lt; 0.0001 respectively) higher than those of the control group (2.3 (2.1) nmol\/l vs 1.7 (0.4) nmol\/l; 8.5 (5.88) mU\/ml vs 4.8 (4.4) mU\/ml; 6.8 (5.1) \u03bcU\/ml vs 9.7 (4.2) \u03bcU\/ml; 19.5 (6.5) vs 4.0 (2.5) respectively). However, the mean level of sex hormone-binding globulin (SHBG) in PCOS group was significantly (<jats:italic>P<\/jats:italic> = 0.004) lower than in control group (36.4(22.6) nmol\/l vs 48.6(25.2) nmol\/l respectively).<\/jats:p>\n      <jats:p><jats:italic>Conclusion<\/jats:italic>: These findings suggest that women with PCOS have a high incidence of genomic instability, and this condition is positively correlated with the hirsutism score, BMI, LH and serum total testosterone and insulin levels, and is negatively correlated with SHBG.<\/jats:p>","DOI":"10.1530\/eje.1.02117","type":"journal-article","created":{"date-parts":[[2006,3,23]],"date-time":"2006-03-23T16:28:31Z","timestamp":1143131311000},"page":"563-568","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":25,"title":["Increased micronucleus frequencies in peripheral blood lymphocytes in women with polycystic ovary syndrome"],"prefix":"10.1093","volume":"154","author":[{"given":"Elif","family":"Yesilada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamdi","family":"Ozcan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim Halil","family":"Yildirim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saim","family":"Yologlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cagatay","family":"Taskapan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/154\/4\/1540563.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/154\/4\/1540563.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:36:08Z","timestamp":1676392568000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/154\/4\/563\/6695550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/eje.1.02117","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}