{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T21:25:44Z","timestamp":1697232344825},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":["eur j endocrinol"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>: To investigate, in a large group of postmenopausal primary hyperparathyroidism (PHP) women, whether the concomitance of GH deficiency (GHD) may contribute to the development of changes in bone mineral density (BMD).<\/jats:p>\n      <jats:p><jats:italic>Design<\/jats:italic>: GH secretion, bone status and metabolism were investigated in 50 postmenopausal women with PHP and in a control group of 60 women with no evidence of PHP, matched for age, age at menopause and body mass index (BMI).<\/jats:p>\n      <jats:p><jats:italic>Methods<\/jats:italic>: GH response to growth hormone-releasing hormone (GHRH)+arginine (Arg), femoral neck BMD (g\/cm<jats:sup>2<\/jats:sup>) by dual energy X-ray absorptiometry, BMI, serum-ionized calcium, parathyroid hormone (PTH) and markers of bone remodelling were evaluated in all patients and controls.<\/jats:p>\n      <jats:p><jats:italic>Results<\/jats:italic>: Among PHP patients, GH secretion was reduced (8.8 \u00b1 4.2 \u03bcg\/l, range 1.1\u201316.5 \u03bcg\/l) in 34 patients and normal (28.7 \u00b1 11.8 \u03bcg\/l, range 17.9\u201355.7 \u03bcg\/l) in the remaining 16 (<jats:italic>P<\/jats:italic> &lt; 0.05), no women in the control group had GHD (peak GH 33.8 \u00b1 10.9 \u03bcg\/l, range 21.7 \u00b1 63.2 \u03bcg\/l). Osteoporosis (<jats:italic>T<\/jats:italic>-score &lt; \u2212 2.5) and osteopenia (<jats:italic>T<\/jats:italic>-score &gt; \u22122.5 and &lt; \u22121) were found in 73.5 and 17.6% of GHD patients, in 37.5 and 43.7% of patients with normal GH secretion and 3.1 and 27% of controls. <jats:italic>T<\/jats:italic>-score and BMD were not correlated with ionized calcium, age, age at menopause, BMI, GH peak and IGF-I but were correlated with serum PTH levels in both groups. <jats:italic>T<\/jats:italic>-score was correlated with serum levels of markers of bone remodelling only in PHP patients with GHD.<\/jats:p>\n      <jats:p><jats:italic>Conclusions<\/jats:italic>: Concomitant impairment of GH secretion may play a pathogenetic role in the occurrence of changes in bone mass observed in PHP and contribute to make them more severe.<\/jats:p>","DOI":"10.1530\/eje.1.02181","type":"journal-article","created":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T16:56:10Z","timestamp":1150995370000},"page":"41-45","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":2,"title":["The reduction of bone mineral density in postmenopausal women with primary hyperparathyroidism is higher in the presence of concomitant GH secretion impairment"],"prefix":"10.1093","volume":"155","author":[{"given":"Elisabetta","family":"Cecconi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Gasperi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maura","family":"Genovesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausto","family":"Bogazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Grasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filomena","family":"Cetani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Procopio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Marcocci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Bartalena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enio","family":"Martino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/155\/1\/1550041.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/155\/1\/1550041.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:33:59Z","timestamp":1676392439000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/155\/1\/41\/6695765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/eje.1.02181","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}