{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:11:04Z","timestamp":1766268664907},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":["eur j endocrinol"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>: Primary hyperparathyroidism (PHPT) is associated with reduced plasma 25-hydroxyvitamin D (P-25OHD) and usually increased plasma 1\u03b1,25-dihydroxyvitamin D (P-1,25(OH)<jats:sub>2<\/jats:sub>D). Parathyroid tissue expresses the vitamin D receptor and it is thought that circulating 1,25(OH)<jats:sub>2<\/jats:sub>D participate in the regulation of parathyroid cell proliferation, differentiation and secretion.<\/jats:p>\n      <jats:p><jats:italic>Aim<\/jats:italic>: To investigate the relations between circulating levels of 1,25(OH)<jats:sub>2<\/jats:sub>D and 25OHD respectively and parathyroid adenoma weight (AW), plasma-parathyroid hormone (P-PTH) and PTH secretion expressed as P-PTH\/AW.<\/jats:p>\n      <jats:p><jats:italic>Design<\/jats:italic>: Cross-sectional study.<\/jats:p>\n      <jats:p><jats:italic>Material<\/jats:italic>: One hundred and seventy-one consecutive hypercalcaemic caucasian patients aged 19\u201387 years (median 63, 84% females) with surgically proven parathyroid adenoma.<\/jats:p>\n      <jats:p><jats:italic>Results<\/jats:italic>: A weak positive correlation was found between P-25OHD and P-1,25(OH)<jats:sub>2<\/jats:sub>D (<jats:italic>r<\/jats:italic> = 0.24, <jats:italic>P<\/jats:italic> &lt; 0.005). AW depended on sex and body mass index. Following adjustment, it was correlated positively to P-PTH, calcium (Ca) and alkaline phosphatase (AP) and inversely to plasma phosphate in a multiple regression model. AW was not associated with vitamin D metabolites. Preoperative P-PTH correlated positively to plasma levels of Ca and AP, but inversely to phosphate and 25OHD (<jats:italic>P<\/jats:italic> &lt; 0.001) levels. P-PTH was not associated with P-1,25(OH)<jats:sub>2<\/jats:sub>D (<jats:italic>P<\/jats:italic> = 0.65). The P-PTH:AW ratio correlated inversely to P-25OHD (<jats:italic>P<\/jats:italic> &lt; 0.05), but showed no relations to plasma levels of Ca, phosphate or 1,25(OH)<jats:sub>2<\/jats:sub>D (<jats:italic>P<\/jats:italic> = 0.22).<\/jats:p>\n      <jats:p><jats:italic>Conclusion<\/jats:italic>: In this material, low levels of 25OHD were related to higher levels of P-PTH and higher PTH:AW ratios in patients with PHPT suggesting that vitamin D deficiency increase PTH secretion activity. Neither PTH secretion nor AW was associated with circulating levels of 1,25(OH)<jats:sub>2<\/jats:sub>D.<\/jats:p>","DOI":"10.1530\/eje.1.02197","type":"journal-article","created":{"date-parts":[[2006,7,25]],"date-time":"2006-07-25T17:47:33Z","timestamp":1153849653000},"page":"237-244","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":43,"title":["Plasma 25-hydroxyvitamin D and not 1,25-dihydroxyvitamin D is associated with parathyroid adenoma secretion in primary hyperparathyroidism: a cross-sectional study"],"prefix":"10.1093","volume":"155","author":[{"given":"B","family":"Moosgaard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Vestergaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Heickendorff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Melsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Mosekilde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/155\/2\/1550237.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/155\/2\/1550237.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:34:06Z","timestamp":1676392446000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/155\/2\/237\/6695748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/eje.1.02197","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}