{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:21:39Z","timestamp":1780503699118,"version":"3.54.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":["eur j endocrinol"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>: Some patients with hyperandrogenemia had no identifiable cause, which was named as idiopathic hyperandrogenemia (IHA). The role of the adrenal glands in these patients was investigated.<\/jats:p>\n      <jats:p><jats:italic>Design<\/jats:italic>: Clinical study in patients with IHA at the Endocrinology Department of a University Hospital.<\/jats:p>\n      <jats:p><jats:italic>Patient(s)<\/jats:italic>: In this study, 26 pre-menopausal women with IHA and 20 healthy women were included. Basal hormonal investigations, ACTH test and a 75 g oral glucose tolerance test (OGTT) were performed. Basal levels of total testosterone, free testosterone, androstenedione (A<jats:sub>4<\/jats:sub>), sex hormone-binding globulin, DHEA sulfate (DHEAS), cortisol, 17-hydroxyprogesterone (17-OHP), 11-deoxycortisol (11-S) and ACTH-stimulated levels of cortisol, A<jats:sub>4<\/jats:sub>, DHEAS, 17-OHP, and 11-S were measured. Additionally, glucose and insulin responses to OGTT were obtained.<\/jats:p>\n      <jats:p><jats:italic>Results<\/jats:italic>: The patients and the control subjects had similar age and body mass index. Peak and area under the curve (AUC) responses of 11-S (<jats:italic>P<\/jats:italic> &lt; 0.05), DHEAS (<jats:italic>P<\/jats:italic> &lt; 0.005), and A<jats:sub>4<\/jats:sub> (peak, <jats:italic>P<\/jats:italic> &lt; 0.005; AUC, <jats:italic>P<\/jats:italic> &lt; 0.001) to ACTH test were significantly higher in the patients with IHA than in the control subjects. There was a significant correlation between the basal DHEAS levels, peak 11-S, and AUC<jats:sub>11-S<\/jats:sub>, in response to ACTH-stimulation test in patients with IHA (<jats:italic>P<\/jats:italic> &lt; 0.005, <jats:italic>r<\/jats:italic>, 0.6). Four (16.6%) patients with IHA had glucose intolerance.<\/jats:p>\n      <jats:p><jats:italic>Conclusion<\/jats:italic>: Our data suggest that adrenal androgen excess may playanimportant role in patients with IHA and these patients exhibit increased prevalence of glucose intolerance.<\/jats:p>","DOI":"10.1530\/eje.1.02212","type":"journal-article","created":{"date-parts":[[2006,7,25]],"date-time":"2006-07-25T17:47:33Z","timestamp":1153849653000},"page":"307-311","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":9,"title":["Investigation of adrenal functions in patients with idiopathic hyperandrogenemia"],"prefix":"10.1093","volume":"155","author":[{"given":"Hulusi","family":"Atmaca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Tanriverdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kursad","family":"Unluhizarci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahri","family":"Bayram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahrettin","family":"Kelestimur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/155\/2\/1550307.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/155\/2\/1550307.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:34:11Z","timestamp":1676392451000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/155\/2\/307\/6695714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/eje.1.02212","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}