{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:54:15Z","timestamp":1768546455266,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":["eur j endocrinol"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>: Hypopituitarism frequently follows pituitary neurosurgery (NS) and\/or irradiation. However, the frequency of hypothalamic\u2013pituitary dysfunction after NS of non-pituitary intracranial tumors is unclear. The aim of this study was to assess the presence of endocrine alterations in patients operated on for intracranial tumors.<\/jats:p>\n      <jats:p><jats:italic>Design<\/jats:italic>: This is a retrospective study.<\/jats:p>\n      <jats:p><jats:italic>Methods<\/jats:italic>: We studied 68 consecutive adult patients (28 female, 40 male, age 45.0 \u00b1 1.8 years; body mass index (BMI): 26.5 \u00b1 0.6) with intracranial tumors who underwent NS only (<jats:italic>n<\/jats:italic> = 17) or in combination with radiotherapy (RT) and\/or chemotherapy (CT) (<jats:italic>n<\/jats:italic> = 51). In all subjects, basal endocrine parameters and the GH response to GHRH + arginine test (using BMI-dependent cut offs) were evaluated.<\/jats:p>\n      <jats:p><jats:italic>Results<\/jats:italic>: In 20.6% of the patients, peripheral endocrinopathy related to CT and\/or RT was present. Hypopituitarism was found in 38.2% of the patients. Total pituitary hormone, multiple pituitary hormone, and isolated pituitary hormone deficits were present in 16.2, 5.8, and 16.2% respectively. The most common pituitary deficits were, in decreasing order: LH\/FSH 29.4%, GH 27.9%, ACTH 19.1%, TSH 17.7%, and diabetes insipidus 4.4%. Hyperprolactinemia was present in 13.2%. The prevalence of hypopituitarism was higher in patients who underwent NS only and with tumors located closely to the sella turcica, but a substantial proportion of patients with tumors not directly neighboring the sella also showed hypopituitarism.<\/jats:p>\n      <jats:p><jats:italic>Conclusions<\/jats:italic>: Hypopituitarism frequently occurs after NS for intracranial tumors. Also, exposure of these patients to CT and\/or RT is frequently associated with peripheral endocrinopathies. Thus, endocrine evaluation and follow-up of patients treated for intracranial tumors should be performed on a regular basis.<\/jats:p>","DOI":"10.1530\/eje.1.02272","type":"journal-article","created":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T23:47:34Z","timestamp":1158882454000},"page":"559-566","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":42,"title":["Endocrine dysfunction in patients operated on for non-pituitary intracranial tumors"],"prefix":"10.1093","volume":"155","author":[{"given":"H J","family":"Schneider","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Rovere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Corneli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C G","family":"Croce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Gasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Ruda\u0300","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Grottoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G K","family":"Stalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Soffietti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Ghigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Aimaretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/155\/4\/1550559.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/155\/4\/1550559.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:34:34Z","timestamp":1676392474000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/155\/4\/559\/6695679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/eje.1.02272","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10]]}}}