{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:48:38Z","timestamp":1762458518118},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":["eur j endocrinol"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>: To evaluate whether Pakistanis have increased bone turnover compared with ethnic Norwegians due to their high prevalence of vitamin D deficiency and secondary hyperparathyroidism, and whether the relation between bone turnover and bone mineral density (BMD) differs between Pakistanis and ethnic Norwegians.<\/jats:p>\n      <jats:p><jats:italic>Design<\/jats:italic>: A cross-sectional, population-based study conducted in the city of Oslo in 2000\u20132001. Random samples of 132 community-dwelling Pakistani men and women of ages 40, 45, and 59\u201360 years, and 580 community-dwelling Norwegian men and women of ages 45 and 59\u201360 years are included in this substudy.<\/jats:p>\n      <jats:p><jats:italic>Methods<\/jats:italic>: Venous serum samples were drawn for measurements of markers of the vitamin D endocrine system and the bone turnover markers osteocalcin (s-OC), bone alkaline phosphatase (s-bone ALP), and tartrate-resistant acid phosphatase (s-TRACP). BMD was measured at the forearm by single-energy X-ray absorptiometry.<\/jats:p>\n      <jats:p><jats:italic>Results<\/jats:italic>: Pakistanis had higher s-bone ALP compared with Norwegians. Mean (95% CI) age-adjusted levels were 22.5 (21.0, 24.1) U\/l in Pakistani men versus 19.3 (18.6, 20.1) U\/l in Norwegian men, <jats:italic>P<\/jats:italic> &lt; 0.0005, and 20.3 (18.4, 22.1) U\/l in Pakistani women versus 16.7 (16.0, 17.4) U\/l in Norwegian women, <jats:italic>P<\/jats:italic> = 0.001. There tended to be an inverse association between bone turnover and BMD in men and women of both ethnic groups, and it was strongest for s-bone ALP. Overall mean (95% CI) distal BMD decrease was \u221216 (\u221220, \u221211) mg\/cm<jats:sup>2<\/jats:sup> per 1 <jats:sc>s.d<\/jats:sc>. increase in s-bone ALP (<jats:italic>P<\/jats:italic> &lt; 0.0005) when adjusting for age, sex, and ethnicity.<\/jats:p>\n      <jats:p><jats:italic>Conclusions<\/jats:italic>: Except for somewhat higher s-bone ALP levels in Pakistanis, there were only minor ethnic differences in bone turnover, despite a strikingly different prevalence of secondary hyperparathyroidism. Bone turnover was inversely associated with forearm BMD in both ethnic groups.<\/jats:p>","DOI":"10.1530\/eje.1.02282","type":"journal-article","created":{"date-parts":[[2006,10,25]],"date-time":"2006-10-25T01:23:29Z","timestamp":1161739409000},"page":"693-699","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":25,"title":["Biochemical markers of bone turnover and their relation to forearm bone mineral density in persons of Pakistani and Norwegian background living in Oslo, Norway: The Oslo Health Study"],"prefix":"10.1093","volume":"155","author":[{"given":"Kristin","family":"Holvik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haakon E","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Johanne","family":"S\u00f8gaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randi","family":"Selmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egil","family":"Haug","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan A","family":"Falch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/155\/5\/1550693.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/155\/5\/1550693.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:34:37Z","timestamp":1676392477000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/155\/5\/693\/6695710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":0,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.1530\/eje.1.02282","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}