{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:29:47Z","timestamp":1790785787371,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":["eur j endocrinol"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>There are few studies that have determined the effects of long-term GH replacement on bone mineral density (BMD) in GH-deficient (GHD) adults. In this study, the effects of 10 years of GH replacement on BMD were assessed in 87 GHD adults using dual energy X-ray absorptiometry (DEXA). The results show that GH replacement induced a sustained increase in BMD at all the skeletal sites measured.<\/jats:p>\n      <jats:p><jats:italic>Introduction<\/jats:italic>: Little is known of the effect of more than 5 years of GH replacement therapy on bone metabolism in GHD adults.<\/jats:p>\n      <jats:p><jats:italic>Patients and methods<\/jats:italic>: In this prospective, open-label, single-center study, which included 87 consecutive adults (52 men and 35 women; mean age of 44.1 (range 22\u201374) years) with adulthood onset GHD, the effect of 10 years of GH replacement on BMD was determined.<\/jats:p>\n      <jats:p><jats:italic>Results<\/jats:italic>: The mean initial dose of GH was 0.98 mg\/day. The dose was gradually lowered and after 10 years the mean dose was 0.47 mg\/day. The mean insulin-like growth factor-I (IGF-I) SDS increased from 1.81 at baseline to 1.29 at study end. The GH replacement induced a sustained increase in total, lumbar (L2\u2013L4) and femur neck BMD, and bone mineral content (BMC) as measured by DEXA. The treatment response in IGF-I SDS was more marked in men, whereas women had a more marked increase in the total body BMC and the total body <jats:italic>z<\/jats:italic>-score. There was a tendency for women on estrogen treatment to have a larger increase in bone mass and density compared with women without estrogen replacement.<\/jats:p>\n      <jats:p><jats:italic>Conclusions<\/jats:italic>: Ten years of GH replacement in hypopituitary adults induced a sustained, and in some variables even a progressive, increase in bone mass and bone density. The study results also suggest that adequate estrogen replacement is needed in order to have an optimal response in BMD in GHD women.<\/jats:p>","DOI":"10.1530\/eje.1.02317","type":"journal-article","created":{"date-parts":[[2007,1,12]],"date-time":"2007-01-12T00:27:47Z","timestamp":1168561667000},"page":"55-64","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":68,"title":["Ten-year GH replacement increases bone mineral density in hypopituitary patients with adult onset GH deficiency"],"prefix":"10.1093","volume":"156","author":[{"given":"G","family":"Go\u0308therstro\u0308m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B-A\u030a","family":"Bengtsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Bos\u00e6us","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Johannsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"6","key":"1_9695870","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1365-2265.1991.tb00930.x","volume":"35","author":"Schlemmer","year":"1991","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"1","key":"2_16388731","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1365-2265.1996.tb02056.x","volume":"45","author":"Amato","year":"1996","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"1","key":"3_5833938","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s002239900392","volume":"62","author":"Kotzmann","year":"1998","journal-title":"Calcified Tissue International","ISSN":"https:\/\/id.crossref.org\/issn\/1432-0827","issn-type":"print"},{"issue":"6","key":"4_16396836","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/8756-3282(96)00069-5","volume":"18","author":"Bravenboer","year":"1996","journal-title":"Bone (New York, N. 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