{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:07:00Z","timestamp":1790176020582,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":["eur j endocrinol"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>: Monocyte chemoattractant protein 1 (MCP-1) has been suggested to be involved in the development of several components of metabolic syndrome (MetS). The present study investigated the association of nine <jats:italic>MCP-1<\/jats:italic> single nucleotide polymorphisms (SNPs) with MetS, type 2 diabetes mellitus and metabolic risk factors.<\/jats:p>\n      <jats:p><jats:italic>Subjects and methods<\/jats:italic>: The population-based study sample comprised 1630 subjects aged 55\u201374 years from KORA S4 (Cooperative Health Research in the Region of Augsburg Survey 4). Genotyping was carried out by matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) analysis of allele-dependent primer extension products.<\/jats:p>\n      <jats:p><jats:italic>Results<\/jats:italic>: The <jats:italic>MCP-1<\/jats:italic> SNP <jats:italic>c.-3813C<\/jats:italic>&gt;<jats:italic>T<\/jats:italic> exhibited trends for differences between the genotype groups in triglycerides, 2-h glucose and uric acid (<jats:italic>P<\/jats:italic> = 0.0084, 0.014, 0.027). Other trends were observed for <jats:italic>c.-928G<\/jats:italic>&gt;<jats:italic>C<\/jats:italic> associated with height and fasting glucose (<jats:italic>P<\/jats:italic> = 0.0024, 0.033), for <jats:italic>c.105T<\/jats:italic>&gt;<jats:italic>C<\/jats:italic> with height and leukocytes (<jats:italic>P<\/jats:italic> = 0.0095, 0.047), for <jats:italic>c.*65C<\/jats:italic>&gt;<jats:italic>T<\/jats:italic> and <jats:italic>c.*3879C<\/jats:italic>&gt;<jats:italic>T<\/jats:italic> with MCP-1 levels (both <jats:italic>P<\/jats:italic> = 0.012) and for <jats:italic>c.-2138A<\/jats:italic>&gt;<jats:italic>T<\/jats:italic> with interleukin-6 levels. After correction for multiple testing, none of the analysed SNPs, except c.-928G&gt;C in men showed a significant association with MetS, T2DM or other analysed parameters. Haplotype <jats:italic>MCP-1*1<\/jats:italic> and <jats:italic>c.-928G<\/jats:italic>&gt;<jats:italic>C<\/jats:italic> in men (<jats:italic>P<\/jats:italic> = 0.0002, 0.0004) were significantly associated with an increase in height.<\/jats:p>\n      <jats:p><jats:italic>Conclusions<\/jats:italic>: This is the first study to investigate the associations of <jats:italic>MCP-1<\/jats:italic> SNPs with MetS. We found trends for several components of MetS. These parameters were hyperlipidaemia, fasting and 2-h glucose, and uric acid. A new finding is that <jats:italic>MCP-1*1<\/jats:italic> haplotype is associated with height. Further investigation in larger populations is needed to clarify the involvement of <jats:italic>MCP-1<\/jats:italic> in MetS.<\/jats:p>","DOI":"10.1530\/eje.1.02345","type":"journal-article","created":{"date-parts":[[2007,2,24]],"date-time":"2007-02-24T04:01:50Z","timestamp":1172289710000},"page":"377-385","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":9,"title":["Gene variants of monocyte chemoattractant protein 1 and components of metabolic syndrome in KORA S4, Augsburg"],"prefix":"10.1093","volume":"156","author":[{"given":"Eva-Maria","family":"Sedlmeier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Grallert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Huth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannelore","family":"Lo\u0308wel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Herder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Strassburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Giani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H-Erich","family":"Wichmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Hauner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Illig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Rathmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/156\/3\/1560377.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/156\/3\/1560377.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:35:04Z","timestamp":1676392504000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/156\/3\/377\/6695827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/eje.1.02345","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}