{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:18:49Z","timestamp":1783448329522,"version":"3.55.0"},"reference-count":21,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":530,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the prevalence, pre-procedure biomarkers, and management of carcinoid crisis (CC) in a cancer-specific hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective observational study of subjects with carcinoid syndrome (CS) undergoing invasive procedures or systemic therapies over 5 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Electronic haemodynamic parameters and patient records were extracted. CC incidence was assessed using strict (SBP &amp;lt;80 mmHg, &amp;gt;10 min) or broad criteria (severe hypotension, hypertension, arrhythmias, &amp;gt;1 min).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>48 patients with CS underwent 71 procedures (35 invasive procedures, 36 systemic therapies). CC did not occur during systemic therapies. Prophylactic octreotide infusion was used in 63% of invasive procedures. CC occurred in 43% of procedures as defined by broad criteria and in 20% as defined by strict criteria. Compared to those without CC, patients with strictly defined CC had higher chromogranin A (P &amp;lt; 0.001), higher 5-HIAA (P = 0.03), higher BNP (P = 0.03), longer hospital stay (P &amp;lt; 0.001), and higher postoperative complications (P &amp;lt; 0.001). Lower intraoperative mean arterial pressure (MAP) correlated with postoperative complications (\u03c1 = \u22120.55, P = 0.004) and longer hospital stay (\u03c1 = \u22120.62, P = 0.001). All subjects with strictly defined CC were treated with more than one drug; however, there were five patients with broadly defined CC who did not require treatment for transient haemodynamic instability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pre-operative biomarker assessment is essential to triage CS patients at risk of CC and thereafter trigger a risk-based management pathway. Prolonged intraoperative hypotension correlated best with postoperative outcomes, and is a better definition for CC in our cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/eo-25-0034","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T10:57:16Z","timestamp":1763031436000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-15","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the carcinoid crisis: insights from a cancer-specific centre"],"prefix":"10.1530","volume":"5","author":[{"given":"Maribel","family":"del 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