{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:18:47Z","timestamp":1783448327518,"version":"3.55.0"},"reference-count":10,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":165,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Paragangliomas (PGLs) are rare neuroendocrine neoplasms of neural-crest origin, with primary mesenteric localization representing an exceptionally uncommon entity that is rarely considered in the preoperative differential diagnosis of mesenteric masses. We report the case of a 51-year-old woman who was referred to our institute following the incidental detection of a 12 \u00d7 9 mm hypervascular nodule within the pelvic small bowel mesentery on contrast-enhanced computed tomography (CT). Subsequent 68Ga-DOTATOC positron emission tomography\/CT showed intense somatostatin receptor uptake confined to the mesenteric nodule, with no other lesions. Dedicated pan-colonoscopy was unremarkable and 24-h urinary 5-hydroxyindoleacetic acid was within normal limits. Preoperative diagnosis of nodal metastasis from an occult ileal neuroendocrine tumor was made, and laparoscopic surgery was undertaken. Meticulous bimanual palpation of the small bowel with transillumination did not reveal any primary lesions, while a 1 cm mesenteric mass was identified and excised. Histology revealed a solid tumor with Zellballen architecture with tumor cells positive for chromogranin A and GATA3, and negative stains for cytokeratin, CDX2, and serotonin, establishing the diagnosis of paraganglioma. This case highlights the importance of recognizing paraganglioma as a potential diagnostic mimic in solitary somatostatin receptor-avid mesenteric nodules to prevent unnecessary investigations and guide appropriate surgical management.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1530\/eo-25-0117","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:55:53Z","timestamp":1774281353000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-15","source":"Crossref","is-referenced-by-count":0,"title":["Mesenteric paraganglioma mimicking nodal metastasis of an occult small intestinal neuroendocrine tumor"],"prefix":"10.1530","volume":"6","author":[{"given":"Anna","family":"Battistella","sequence":"first","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Schiavo Lena","sequence":"additional","affiliation":[{"name":"3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Andreasi","sequence":"additional","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8938-6170","authenticated-orcid":true,"given":"Stefano","family":"Partelli","sequence":"additional","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Falconi","sequence":"additional","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"2026070713575443300_bib1","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1210\/jc.2014-1498","article-title":"Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline","volume":"99","author":"Lenders","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2026070713575443300_bib2","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1007\/s12094-021-02622-9","article-title":"Multidisciplinary practice guidelines for the diagnosis, genetic counseling and treatment of pheochromocytomas and paragangliomas","volume":"23","author":"Garcia-Carbonero","year":"2021","journal-title":"Clin Transl Oncol"},{"key":"2026070713575443300_bib3","doi-asserted-by":"crossref","DOI":"10.1111\/jne.13423","article-title":"European Neuroendocrine Tumor Society (ENETS) 2024 guidance paper for the management of well-differentiated small intestine neuroendocrine tumours","volume":"36","author":"Lamarca","year":"2024","journal-title":"J Neuroendocrinol"},{"key":"2026070713575443300_bib4","volume-title":"WHO Classification of Endocrine and Neuroendocrine Tumours","author":"WHO","year":"2025","edition":"5th edn"},{"key":"2026070713575443300_bib5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1530\/ERC-13-0494","article-title":"Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma","volume":"21","author":"Kimura","year":"2014","journal-title":"Endocr Relat Cancer"},{"key":"2026070713575443300_bib6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00000658-195607000-00020","article-title":"Intra-abdominal non-chromaffin paraganglioma","volume":"144","author":"Arean","year":"1956","journal-title":"Ann Surg"},{"key":"2026070713575443300_bib7","article-title":"Mesenteric paraganglioma: a case report and literature review","volume":"15","author":"Lim","year":"2023","journal-title":"Cureus"},{"key":"2026070713575443300_bib8","article-title":"A rare case of a 65 year old female with a mesenteric paraganglioma","volume":"19","author":"Rocco","year":"2020","journal-title":"Hum Pathol Case Rep"},{"key":"2026070713575443300_bib9","first-page":"1","article-title":"An unusual presentation of mesenteric paraganglioma","volume":"9","author":"Alexandre Viana Ferreira","year":"2018","journal-title":"Int J Case Rep Imag"},{"key":"2026070713575443300_bib10","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.3390\/cancers15164065","article-title":"Urinary 5-hydroxyindolacetic acid measurements in patients with neuroendocrine tumor-related carcinoid syndrome: state of the art","volume":"15","author":"Rossi","year":"2023","journal-title":"Cancers"}],"container-title":["Endocrine Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eo.bioscientifica.com\/view\/journals\/eo\/6\/1\/EO-25-0117.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eo.bioscientifica.com\/downloadpdf\/journals\/eo\/6\/1\/EO-25-0117.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/eo\/article-pdf\/doi\/10.1530\/EO-25-0117\/505703\/eo-25-0117.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/eo\/article-pdf\/doi\/10.1530\/EO-25-0117\/505703\/eo-25-0117.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:58:21Z","timestamp":1783447101000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/eo\/article\/6\/1\/e250117\/75486\/Mesenteric-paraganglioma-mimicking-nodal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1530\/eo-25-0117","relation":{},"ISSN":["2634-4793"],"issn-type":[{"value":"2634-4793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]},"article-number":"e250117"}}