{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:52:13Z","timestamp":1792072333677,"version":"4.4.0"},"reference-count":48,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":280,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thyroid cancer is one of the most common endocrine malignancies, with an excellent long-term survival rate. As survivorship increases, attention has shifted towards chronic endocrine sequelae, including disturbances of gonadal function and fertility. Thyroid cancer therapies, including thyroidectomy, long-term thyroid-stimulating hormone (TSH) suppressive therapy, radioiodine (RAI), and targeted systemic treatments, may interfere with reproductive health through complex endocrine and gonadal mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This narrative review aims to examine the pathophysiological pathways linking thyroid cancer and its treatments to reproductive health in both men and women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thyroidectomy and chronic TSH suppression may alter sex steroid bioavailability and gonadotrophin regulation through changes in thyroid hormone signalling and sex hormone-binding globulin synthesis. RAI therapy exerts dose-dependent gonadotoxic effects, particularly affecting ovarian reserve and spermatogenesis, often in a transient and reversible manner, but potentially accelerating reproductive ageing and damage. Targeted therapies may also contribute to reproductive dysfunction through indirect systemic and endocrine mechanisms; however, data on thyroid cancer patients are still limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Thyroid cancer-related reproductive dysfunction may arise from the interaction of endocrine- and treatment-related mechanisms. Although often subclinical, these alterations are biologically relevant and may influence long-term fertility potential. An accurate counselling for fertility management in thyroid cancer survivors appears relevant and highlights areas for future research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/eo-26-0047","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:08:01Z","timestamp":1791450481000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-15","source":"Crossref","is-referenced-by-count":0,"title":["Reproductive function in thyroid cancer survivors: a gender-based perspective on outcomes"],"prefix":"10.1530","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6707-3413","authenticated-orcid":true,"given":"Rossella","family":"Mazzilli","sequence":"first","affiliation":[{"name":"Endocrinology Unit, Department of Clinical and Molecular Medicine, Sapienza University of Rome 1 , ,","place":["Rome, 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Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Vaccaro","sequence":"additional","affiliation":[{"name":"Division of Oncological Endocrinology, Citt\u00e0 della Salute e della Scienza Hospital 2 , ,","place":["Turin, Italy"]},{"name":"Department of Medical Sciences, University of Turin 3 , ,","place":["Torino, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Defeudis","sequence":"additional","affiliation":[{"name":"Department of Theoretical and Applied Sciences, eCampus University 4 , ,","place":["Novedrate CO, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Arvat","sequence":"additional","affiliation":[{"name":"Division of Oncological Endocrinology, Citt\u00e0 della Salute e della Scienza Hospital 2 , ,","place":["Turin, Italy"]},{"name":"Department of Medical Sciences, University of Turin 3 , ,","place":["Torino, 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