{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:13:33Z","timestamp":1787022813517,"version":"build-2736575974"},"reference-count":94,"publisher":"Bioscientifica","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["eor.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Malignant bone tumors, including primary bone tumors, such as osteosarcoma (OS), Ewing\u2019s sarcoma (ES), and multiple myeloma, and secondary bone tumors from prostate and breast cancers, pose significant mortality risks. Osteoblasts (OBs) and their derivatives play critical roles in the development, recurrence, and metastasis of these tumors.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>OBs promote metastasis-related events, including osteoclast differentiation and proliferation. Their derivatives, including extracellular vesicles and cytokines, modulate bone remodeling and tumor development through various signaling pathways.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Recent\n                          <jats:italic>in vivo<\/jats:italic>\n                          and\n                          <jats:italic>in vitro<\/jats:italic>\n                          studies highlight the involvement of OBs in tumor progression, recurrence, and metastasis. Emerging therapies targeting OBs and their derivatives show promise in improving patient outcomes.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>The review emphasizes the importance of understanding the specific roles of OBs and their derivatives in malignant bone tumors. This knowledge can lead to the development of new therapeutic strategies aimed at improving patient survival rates and quality of life.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Key findings include the regulatory effects of OBs on tumor dormancy, the vicious cycle of bone metastasis, and the potential for targeted therapies to disrupt these processes.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Future research should focus on developing experimental models that more closely mimic the human tumor microenvironment and integrating multiple signaling pathways to create comprehensive treatment strategies.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1530\/eor-2025-0021","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T13:46:18Z","timestamp":1764942378000},"page":"882-893","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":2,"title":["Research advances in the role of osteoblasts and their derivatives in the development, recurrence, and distant metastasis of malignant bone tumors: a narrative review"],"prefix":"10.1530","volume":"10","author":[{"given":"Xuanhe","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Surgery, Children\u2019s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Qiang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Children\u2019s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Children\u2019s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanyu","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Children\u2019s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Children\u2019s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8647-4818","authenticated-orcid":true,"given":"Pengfei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Children\u2019s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"CA Cancer J Clin","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray F","year":"2024","unstructured":"Bray F\n, \nLaversanne M\n, \nSung H\n, et al.\n Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2024 74 229\u2013263. (https:\/\/doi.org\/10.3322\/caac.21834)"},{"key":"bib2","series-title":"Nat Rev Dis Primers","first-page":"77","article-title":"Osteosarcoma","volume":"8","author":"Beird HC","year":"2022","unstructured":"Beird HC\n, \nBielack SS\n, \nFlanagan AM\n, et al.\n Osteosarcoma. Nat Rev Dis Primers 2022 8 77. (https:\/\/doi.org\/10.1038\/s41572-022-00409-y)"},{"key":"bib3","series-title":"N Engl J Med","first-page":"1046","article-title":"Multiple myeloma","volume":"364","author":"Palumbo A","year":"2011","unstructured":"Palumbo A\n & \nAnderson K\n\n. Multiple myeloma. N Engl J Med 2011 364 1046\u20131060. (https:\/\/doi.org\/10.1056\/nejmra1011442)"},{"key":"bib4","series-title":"Curr Oncol Rep","first-page":"71","article-title":"Update on osteosarcoma","volume":"23","author":"Belayneh R","year":"2021","unstructured":"Belayneh R\n, \nFourman MS\n, \nBhogal S\n, et al.\n Update on osteosarcoma. Curr Oncol Rep 2021 23 71. (https:\/\/doi.org\/10.1007\/s11912-021-01053-7)"},{"key":"bib5","series-title":"Signal Transduct Target Ther","first-page":"287","article-title":"Targeting TRPV6\/CXCR4 complexes prevents castration-resistant prostate cancer metastasis to the bone","volume":"10","author":"Cordier C","year":"2025","unstructured":"Cordier C\n, \nHaustrate A\n, \nMihalache A\n, et al.\n Targeting TRPV6\/CXCR4 complexes prevents castration-resistant prostate cancer metastasis to the bone. Signal Transduct Target Ther 2025 10 287. (https:\/\/doi.org\/10.1038\/s41392-025-02376-8)"},{"key":"bib6","series-title":"J Orthop Translat","first-page":"264","article-title":"Mesoporous bioactive glass-enhanced MSC-derived exosomes promote bone regeneration and immunomodulation in vitro and in vivo","volume":"49","author":"Wa Q","year":"2024","unstructured":"Wa Q\n, \nLuo Y\n, \nTang Y\n, et al.\n Mesoporous bioactive glass-enhanced MSC-derived exosomes promote bone regeneration and immunomodulation in vitro and in vivo. J Orthop Translat 2024 49 264\u2013282. (https:\/\/doi.org\/10.1016\/j.jot.2024.09.009)"},{"key":"bib7","series-title":"Cell Rep","article-title":"YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1-mediated reprogramming of bone mesenchymal stem cells","volume":"44","author":"Noorizadeh R","year":"2025","unstructured":"Noorizadeh R\n, \nSax B\n, \nJavaheri T\n, et al.\n YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1-mediated reprogramming of bone mesenchymal stem cells. Cell Rep 2025 44 115381. (https:\/\/doi.org\/10.1016\/j.celrep.2025.115381)"},{"key":"bib8","series-title":"Nucleic Acids Res","article-title":"Structure and cooperative formation of a FLI1 filament on contiguous GGAA DNA sites","volume":"53","author":"Hou C","year":"2025","unstructured":"Hou C\n & \nTsodikov OV\n\n. Structure and cooperative formation of a FLI1 filament on contiguous GGAA DNA sites. Nucleic Acids Res 2025 53 gkaf205. (https:\/\/doi.org\/10.1093\/nar\/gkaf205)"},{"key":"bib9","series-title":"Bone","article-title":"Osteoblast-derived exosomes promote osteogenic differentiation of osteosarcoma cells via URG4\/Wnt signaling pathway","volume":"178","author":"Leng Y","year":"2024","unstructured":"Leng Y\n, \nLi J\n, \nLong Z\n, et al.\n Osteoblast-derived exosomes promote osteogenic differentiation of osteosarcoma cells via URG4\/Wnt signaling pathway. Bone 2024 178 116933. (https:\/\/doi.org\/10.1016\/j.bone.2023.116933)"},{"key":"bib10","series-title":"Biochim Biophys Acta Mol Cell Res","article-title":"Osteoblastic protein kinase D1 contributes to the prostate cancer cells dormancy via GAS6-circadian clock signaling","volume":"1869","author":"Li G","year":"2022","unstructured":"Li G\n, \nFan M\n, \nZheng Z\n, et al.\n Osteoblastic protein kinase D1 contributes to the prostate cancer cells dormancy via GAS6-circadian clock signaling. Biochim Biophys Acta Mol Cell Res 2022 1869 119296. (https:\/\/doi.org\/10.1016\/j.bbamcr.2022.119296)"},{"key":"bib11","series-title":"J Exp Clin Cancer Res","first-page":"316","article-title":"Osteoblasts and osteoclasts: an important switch of tumour cell dormancy during bone metastasis","volume":"41","author":"Dai R","year":"2022","unstructured":"Dai R\n, \nLiu M\n, \nXiang X\n, et al.\n Osteoblasts and osteoclasts: an important switch of tumour cell dormancy during bone metastasis. J Exp Clin Cancer Res 2022 41 316. (https:\/\/doi.org\/10.1186\/s13046-022-02520-0)"},{"key":"bib12","series-title":"Bone Res","first-page":"6","article-title":"GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation","volume":"10","author":"Siddiqui JA","year":"2022","unstructured":"Siddiqui JA\n, \nSeshacharyulu P\n, \nMuniyan S\n, et al.\n GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation. Bone Res 2022 10 6. (https:\/\/doi.org\/10.1038\/s41413-021-00178-6)"},{"key":"bib13","series-title":"Cells","first-page":"25","article-title":"Establishment and characterization of cell lines from canine metastatic osteosarcoma","volume":"13","author":"Yang YT","year":"2023","unstructured":"Yang YT\n, \nEngleberg AI\n & \nYuzbasiyan-Gurkan V\n\n. Establishment and characterization of cell lines from canine metastatic osteosarcoma. Cells 2023 13 25. (https:\/\/doi.org\/10.3390\/cells13010025)"},{"key":"bib14","series-title":"Oncol Rep","article-title":"Prostate cancer cell-derived spondin 2 boosts osteogenic factor levels in osteoblasts via the PI3K\/AKT\/mTOR pathway","volume":"49","author":"Wang H","year":"2023","unstructured":"Wang H\n, \nZhang M\n, \nLu W\n, et al.\n Prostate cancer cell-derived spondin 2 boosts osteogenic factor levels in osteoblasts via the PI3K\/AKT\/mTOR pathway. Oncol Rep 2023 49 23. (https:\/\/doi.org\/10.3892\/or.2022.8460)"},{"key":"bib15","series-title":"J Orthop Translat","first-page":"132","article-title":"Runx2 plays a central role in osteoarthritis development","volume":"23","author":"Chen D","year":"2020","unstructured":"Chen D\n, \nKim DJ\n, \nShen J\n, et al.\n Runx2 plays a central role in osteoarthritis development. J Orthop Translat 2020 23 132\u2013139. (https:\/\/doi.org\/10.1016\/j.jot.2019.11.008)"},{"key":"bib16","series-title":"Int J Mol Sci","first-page":"1694","article-title":"Regulation of proliferation, differentiation and functions of osteoblasts by Runx2","volume":"20","author":"Komori T","year":"2019","unstructured":"Komori T\n\n. Regulation of proliferation, differentiation and functions of osteoblasts by Runx2. Int J Mol Sci 2019 20 1694. (https:\/\/doi.org\/10.3390\/ijms20071694)"},{"key":"bib17","series-title":"Lab Invest","first-page":"271","article-title":"KLF2 regulates osteoblast differentiation by targeting of Runx2","volume":"99","author":"Hou Z","year":"2019","unstructured":"Hou Z\n, \nWang Z\n, \nTao Y\n, et al.\n KLF2 regulates osteoblast differentiation by targeting of Runx2. Lab Invest 2019 99 271\u2013280. (https:\/\/doi.org\/10.1038\/s41374-018-0149-x)"},{"key":"bib18","series-title":"FASEB J","first-page":"4681","article-title":"A new role for HERPUD1 and ERAD activation in osteoblast differentiation and mineralization","volume":"32","author":"Americo-Da-Silva L","year":"2018","unstructured":"Americo-Da-Silva L\n, \nDiaz J\n, \nBustamante M\n, et al.\n A new role for HERPUD1 and ERAD activation in osteoblast differentiation and mineralization. FASEB J 2018 32 4681\u20134695. (https:\/\/doi.org\/10.1096\/fj.201701229rr)"},{"key":"bib19","series-title":"Semin Immunopathol","first-page":"565","article-title":"Metabolic reprogramming in osteoclasts","volume":"41","author":"Park-Min KH","year":"2019","unstructured":"Park-Min KH\n\n. Metabolic reprogramming in osteoclasts. Semin Immunopathol 2019 41 565\u2013572. (https:\/\/doi.org\/10.1007\/s00281-019-00757-0)"},{"key":"bib20","series-title":"Semin Cell Dev Biol","first-page":"8","article-title":"Osteoclast formation at the bone marrow\/bone surface interface: importance of structural elements, matrix, and intercellular communication","volume":"112","author":"Soe K","year":"2021","unstructured":"Soe K\n, \nDelaisse JM\n & \nBorggaard XG\n\n. Osteoclast formation at the bone marrow\/bone surface interface: importance of structural elements, matrix, and intercellular communication. Semin Cell Dev Biol 2021 112 8\u201315. (https:\/\/doi.org\/10.1016\/j.semcdb.2020.05.016)"},{"key":"bib21","series-title":"Bone","article-title":"Epigenetic and transcriptional regulation of osteoclast differentiation","volume":"138","author":"Kurotaki D","year":"2020","unstructured":"Kurotaki D\n, \nYoshida H\n & \nTamura T\n\n. Epigenetic and transcriptional regulation of osteoclast differentiation. Bone 2020 138 115471. (https:\/\/doi.org\/10.1016\/j.bone.2020.115471)"},{"key":"bib22","series-title":"Oncol Rep","first-page":"2636","article-title":"The PI3K inhibitor buparlisib suppresses osteoclast formation and tumour cell growth in bone metastasis of lung cancer, as evidenced by multimodality molecular imaging","volume":"41","author":"Wang S","year":"2019","unstructured":"Wang S\n, \nNiu X\n, \nBao X\n, et al.\n The PI3K inhibitor buparlisib suppresses osteoclast formation and tumour cell growth in bone metastasis of lung cancer, as evidenced by multimodality molecular imaging. Oncol Rep 2019 41 2636\u20132646. (https:\/\/doi.org\/10.3892\/or.2019.7080)"},{"key":"bib23","series-title":"Pathol Oncol Res","article-title":"Osteoclasts in tumor biology: metastasis and epithelial-mesenchymal-myeloid transition","volume":"27","author":"Behzatoglu K","year":"2021","unstructured":"Behzatoglu K\n\n. Osteoclasts in tumor biology: metastasis and epithelial-mesenchymal-myeloid transition. Pathol Oncol Res 2021 27 609472. (https:\/\/doi.org\/10.3389\/pore.2021.609472)"},{"key":"bib24","series-title":"Front Oncol","first-page":"1283","article-title":"Targeting the RANKL\/RANK\/OPG axis for cancer therapy","volume":"10","author":"Ming J","year":"2020","unstructured":"Ming J\n, \nCronin SJF\n & \nPenninger JM\n\n. Targeting the RANKL\/RANK\/OPG axis for cancer therapy. Front Oncol 2020 10 1283. (https:\/\/doi.org\/10.3389\/fonc.2020.01283)"},{"key":"bib25","series-title":"Cytokine","article-title":"The hidden secrets of soluble RANKL in bone biology","volume":"144","author":"Elango J","year":"2021","unstructured":"Elango J\n, \nBao B\n & \nWu W\n\n. The hidden secrets of soluble RANKL in bone biology. Cytokine 2021 144 155559. (https:\/\/doi.org\/10.1016\/j.cyto.2021.155559)"},{"key":"bib26","series-title":"Front Immunol","article-title":"Beyond inflammation: the molecular basis of bone remodeling in axial spondyloarthritis and psoriatic arthritis","volume":"16","author":"Lopalco G","year":"2025","unstructured":"Lopalco G\n, \nCito A\n, \nIannone F\n, et al.\n Beyond inflammation: the molecular basis of bone remodeling in axial spondyloarthritis and psoriatic arthritis. Front Immunol 2025 16 1599995. (https:\/\/doi.org\/10.3389\/fimmu.2025.1599995)"},{"key":"bib27","series-title":"Proc Natl Acad Sci U S A","first-page":"17187","article-title":"Antiresorptive activity of osteoprotegerin requires an intact heparan sulfate-binding site","volume":"117","author":"Li M","year":"2020","unstructured":"Li M\n & \nXu D\n\n. Antiresorptive activity of osteoprotegerin requires an intact heparan sulfate-binding site. Proc Natl Acad Sci U S A 2020 117 17187\u201317194. (https:\/\/doi.org\/10.1073\/pnas.2005859117)"},{"key":"bib28","series-title":"Cell Res","first-page":"885","article-title":"Wnt signaling and Loxl2 promote aggressive osteosarcoma","volume":"30","author":"Matsuoka K","year":"2020","unstructured":"Matsuoka K\n, \nBakiri L\n, \nWolff LI\n, et al.\n Wnt signaling and Loxl2 promote aggressive osteosarcoma. Cell Res 2020 30 885\u2013901. (https:\/\/doi.org\/10.1038\/s41422-020-0370-1)"},{"key":"bib29","series-title":"Oncogene","first-page":"1231","article-title":"Hypoxia-induced CREB cooperates MMSET to modify chromatin and promote DKK1 expression in multiple myeloma","volume":"40","author":"Xu Y","year":"2021","unstructured":"Xu Y\n, \nGuo J\n, \nLiu J\n, et al.\n Hypoxia-induced CREB cooperates MMSET to modify chromatin and promote DKK1 expression in multiple myeloma. Oncogene 2021 40 1231\u20131241. (https:\/\/doi.org\/10.1038\/s41388-020-01590-8)"},{"key":"bib30","series-title":"Cell Death Dis","first-page":"376","article-title":"Knockdown of MCM8 functions as a strategy to inhibit the development and progression of osteosarcoma through regulating CTGF","volume":"12","author":"Ren Z","year":"2021","unstructured":"Ren Z\n, \nLi J\n, \nZhao S\n, et al.\n Knockdown of MCM8 functions as a strategy to inhibit the development and progression of osteosarcoma through regulating CTGF. Cell Death Dis 2021 12 376. (https:\/\/doi.org\/10.1038\/s41419-021-03621-y)"},{"key":"bib31","series-title":"Int Immunopharmacol","article-title":"Abnormal expression pattern of lncRNA H19 participates in multiple myeloma bone disease by unbalancing osteogenesis and osteolysis","volume":"119","author":"Guo N","year":"2023","unstructured":"Guo N\n, \nSong Y\n, \nZi F\n, et al.\n Abnormal expression pattern of lncRNA H19 participates in multiple myeloma bone disease by unbalancing osteogenesis and osteolysis. Int Immunopharmacol 2023 119 110058. (https:\/\/doi.org\/10.1016\/j.intimp.2023.110058)"},{"key":"bib32","series-title":"Nat Cell Biol","first-page":"298","article-title":"ETV6 dependency in ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation","volume":"25","author":"Gao Y","year":"2023","unstructured":"Gao Y\n, \nHe XY\n, \nWu XS\n, et al.\n ETV6 dependency in ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation. Nat Cell Biol 2023 25 298\u2013308. (https:\/\/doi.org\/10.1038\/s41556-022-01060-1)"},{"key":"bib33","series-title":"Leukemia","first-page":"540","article-title":"Circulating cytokines present in multiple myeloma patients inhibit the osteoblastic differentiation of adipose stem cells","volume":"36","author":"Kobari L","year":"2022","unstructured":"Kobari L\n, \nAuclair M\n, \nPiau O\n, et al.\n Circulating cytokines present in multiple myeloma patients inhibit the osteoblastic differentiation of adipose stem cells. Leukemia 2022 36 540\u2013548. (https:\/\/doi.org\/10.1038\/s41375-021-01428-6)"},{"key":"bib34","series-title":"Curr Treat Options Oncol","first-page":"82","article-title":"The multidisciplinary management of osteosarcoma","volume":"10","author":"Federman N","year":"2009","unstructured":"Federman N\n, \nBernthal N\n, \nEilber FC\n, et al.\n The multidisciplinary management of osteosarcoma. Curr Treat Options Oncol 2009 10 82\u201393. (https:\/\/doi.org\/10.1007\/s11864-009-0087-3)"},{"key":"bib35","series-title":"J Orthop Surg Res","first-page":"346","article-title":"Functional outcome of surgical treatment of adults with extremity osteosarcoma after megaprosthetic reconstruction-single-center experience","volume":"14","author":"Gory\u0144 T","year":"2019","unstructured":"Gory\u0144 T\n, \nPie\u0144kowski A\n, \nSzostakowski B\n, et al.\n Functional outcome of surgical treatment of adults with extremity osteosarcoma after megaprosthetic reconstruction-single-center experience. J Orthop Surg Res 2019 14 346. (https:\/\/doi.org\/10.1186\/s13018-019-1379-3)"},{"key":"bib36","series-title":"Breast Cancer Res Treat","first-page":"135","article-title":"Transcriptome analysis reveals an osteoblast-like phenotype for human osteotropic breast cancer cells","volume":"101","author":"Bellahcene A","year":"2007","unstructured":"Bellahcene A\n, \nBachelier R\n, \nDetry C\n, et al.\n Transcriptome analysis reveals an osteoblast-like phenotype for human osteotropic breast cancer cells. Breast Cancer Res Treat 2007 101 135\u2013148. (https:\/\/doi.org\/10.1007\/s10549-006-9279-8)"},{"key":"bib37","series-title":"Biochim Biophys Acta Rev Cancer","article-title":"Osteoblasts in bone metastasis: key players in the tumor microenvironment and therapeutic targets","volume":"1880","author":"Jin L","year":"2025","unstructured":"Jin L\n, \nShao Z\n, \nYe Z\n, et al.\n Osteoblasts in bone metastasis: key players in the tumor microenvironment and therapeutic targets. Biochim Biophys Acta Rev Cancer 2025 1880 189435. (https:\/\/doi.org\/10.1016\/j.bbcan.2025.189435)"},{"key":"bib38","series-title":"Cancer Sci","first-page":"3660","article-title":"Identification of ENO-1 positive extracellular vesicles as a circulating biomarker for monitoring of ewing sarcoma","volume":"115","author":"Uotani K","year":"2024","unstructured":"Uotani K\n, \nFujiwara T\n, \nUeda K\n, et al.\n Identification of ENO-1 positive extracellular vesicles as a circulating biomarker for monitoring of ewing sarcoma. Cancer Sci 2024 115 3660\u20133671. (https:\/\/doi.org\/10.1111\/cas.16343)"},{"key":"bib39","series-title":"Nat Commun","first-page":"8983","article-title":"Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche","volume":"6","author":"Lawson MA","year":"2015","unstructured":"Lawson MA\n, \nMcDonald MM\n, \nKovacic N\n, et al.\n Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche. Nat Commun 2015 6 8983. (https:\/\/doi.org\/10.1038\/ncomms9983)"},{"key":"bib40","series-title":"Nat Commun","first-page":"8057","article-title":"A strategy for challenging tumorous bone regeneration by borosilicate bioactive glass boosting moderate magnetic hyperthermia","volume":"16","author":"Fan M","year":"2025","unstructured":"Fan M\n, \nLiu C\n, \nZhang Y\n, et al.\n A strategy for challenging tumorous bone regeneration by borosilicate bioactive glass boosting moderate magnetic hyperthermia. Nat Commun 2025 16 8057. (https:\/\/doi.org\/10.1038\/s41467-025-63270-z)"},{"key":"bib41","series-title":"Breast Cancer Res Treat","first-page":"73","article-title":"Osteolytic bone metastasis in breast cancer","volume":"32","author":"Yoneda T","year":"1994","unstructured":"Yoneda T\n, \nSasaki A\n & \nMundy GR\n\n. Osteolytic bone metastasis in breast cancer. Breast Cancer Res Treat 1994 32 73\u201384. (https:\/\/doi.org\/10.1007\/bf00666208)"},{"key":"bib42","series-title":"Front Immunol","article-title":"Multiple influence of immune cells in the bone metastatic cancer microenvironment on tumors","volume":"15","author":"Chen S","year":"2024","unstructured":"Chen S\n, \nLei J\n, \nMou H\n, et al.\n Multiple influence of immune cells in the bone metastatic cancer microenvironment on tumors. Front Immunol 2024 15 1335366. (https:\/\/doi.org\/10.3389\/fimmu.2024.1335366)"},{"key":"bib43","series-title":"BMC Cancer","first-page":"1059","article-title":"EMMPRIN expression is associated with metastatic progression in osteosarcoma","volume":"21","author":"Kim HS","year":"2021","unstructured":"Kim HS\n, \nKim HJ\n, \nLee MR\n, et al.\n EMMPRIN expression is associated with metastatic progression in osteosarcoma. BMC Cancer 2021 21 1059. (https:\/\/doi.org\/10.1186\/s12885-021-08774-9)"},{"key":"bib44","series-title":"J Pathol","first-page":"199","article-title":"The EMT transcription factor ZEB1 blocks osteoblastic differentiation in bone development and osteosarcoma","volume":"254","author":"Ruh M","year":"2021","unstructured":"Ruh M\n, \nStemmler MP\n, \nFrisch I\n, et al.\n The EMT transcription factor ZEB1 blocks osteoblastic differentiation in bone development and osteosarcoma. J Pathol 2021 254 199\u2013211. (https:\/\/doi.org\/10.1002\/path.5659)"},{"key":"bib45","series-title":"Int J Mol Sci","first-page":"705","article-title":"Potential anti-metastatic role of the novel miR-CT3 in tumor angiogenesis and osteosarcoma invasion","volume":"23","author":"Raimondi L","year":"2022","unstructured":"Raimondi L\n, \nGallo A\n, \nCuscino N\n, et al.\n Potential anti-metastatic role of the novel miR-CT3 in tumor angiogenesis and osteosarcoma invasion. Int J Mol Sci 2022 23 705. (https:\/\/doi.org\/10.3390\/ijms23020705)"},{"key":"bib46","series-title":"Bone","article-title":"Anti-osteoblastogenic, pro-inflammatory and pro-angiogenic effect of extracellular vesicles isolated from the human osteosarcoma cell line MNNG\/HOS","volume":"153","author":"Ucci A","year":"2021","unstructured":"Ucci A\n, \nCappariello A\n, \nPonzetti M\n, et al.\n Anti-osteoblastogenic, pro-inflammatory and pro-angiogenic effect of extracellular vesicles isolated from the human osteosarcoma cell line MNNG\/HOS. Bone 2021 153 116130. (https:\/\/doi.org\/10.1016\/j.bone.2021.116130)"},{"key":"bib47","series-title":"Cell Death Discov","first-page":"219","article-title":"Reelin depletion alleviates multiple myeloma bone disease by promoting osteogenesis and inhibiting osteolysis","volume":"7","author":"Dou A","year":"2021","unstructured":"Dou A\n, \nZhang Y\n, \nWang Y\n, et al.\n Reelin depletion alleviates multiple myeloma bone disease by promoting osteogenesis and inhibiting osteolysis. Cell Death Discov 2021 7 219. (https:\/\/doi.org\/10.1038\/s41420-021-00608-8)"},{"key":"bib48","series-title":"Clin Exp Metastasis","first-page":"579","article-title":"Cadherin-11 regulates the metastasis of ewing sarcoma cells to bone","volume":"32","author":"Hatano M","year":"2015","unstructured":"Hatano M\n, \nMatsumoto Y\n, \nFukushi J\n, et al.\n Cadherin-11 regulates the metastasis of ewing sarcoma cells to bone. Clin Exp Metastasis 2015 32 579\u2013591. (https:\/\/doi.org\/10.1007\/s10585-015-9729-y)"},{"key":"bib49","series-title":"Front Cell Dev Biol","article-title":"Acid-induced inflammatory cytokines in osteoblasts: a guided path to osteolysis in bone metastasis","volume":"9","author":"Di Pompo G","year":"2021","unstructured":"Di Pompo G\n, \nErrani C\n, \nGillies R\n, et al.\n Acid-induced inflammatory cytokines in osteoblasts: a guided path to osteolysis in bone metastasis. Front Cell Dev Biol 2021 9 678532. (https:\/\/doi.org\/10.3389\/fcell.2021.678532)"},{"key":"bib50","series-title":"Cancer Res","first-page":"4341","article-title":"Metastasis-initiating osteosarcoma subpopulations establish paracrine interactions with lung and tumor cells to create a metastatic niche","volume":"85","author":"Reinecke JB","year":"2025","unstructured":"Reinecke JB\n, \nJimenez Garcia L\n, \nSaraf AJ\n, et al.\n Metastasis-initiating osteosarcoma subpopulations establish paracrine interactions with lung and tumor cells to create a metastatic niche. Cancer Res 2025 85 4341\u20134358. (https:\/\/doi.org\/10.1158\/0008-5472.can-24-3360)"},{"key":"bib51","series-title":"Acta Pharm Sin B","first-page":"2039","article-title":"Exosomes derived from pulmonary metastatic sites enhance osteosarcoma lung metastasis by transferring the miR-194\/215 cluster targeting MARCKS","volume":"14","author":"Yu P","year":"2024","unstructured":"Yu P\n, \nHan Y\n, \nMeng L\n, et al.\n Exosomes derived from pulmonary metastatic sites enhance osteosarcoma lung metastasis by transferring the miR-194\/215 cluster targeting MARCKS. Acta Pharm Sin B 2024 14 2039\u20132056. (https:\/\/doi.org\/10.1016\/j.apsb.2024.01.016)"},{"key":"bib52","series-title":"Oncogene","first-page":"2696","article-title":"A noncanonical E3 ubiquitin ligase RNF41-mediated MYO1C stability promotes prostate cancer metastasis by inducing actin remodeling","volume":"43","author":"Xiong S","year":"2024","unstructured":"Xiong S\n, \nLi S\n, \nLi Z\n, et al.\n A noncanonical E3 ubiquitin ligase RNF41-mediated MYO1C stability promotes prostate cancer metastasis by inducing actin remodeling. Oncogene 2024 43 2696\u20132707. (https:\/\/doi.org\/10.1038\/s41388-024-03120-2)"},{"key":"bib53","series-title":"J Cell Mol Med","article-title":"Identification of prostate cancer bone metastasis related genes and potential therapy targets by bioinformatics and in vitro experiments","volume":"28","author":"Jiang H","year":"2024","unstructured":"Jiang H\n, \nLiu M\n, \nDeng Y\n, et al.\n Identification of prostate cancer bone metastasis related genes and potential therapy targets by bioinformatics and in vitro experiments. J Cell Mol Med 2024 28 e18511. (https:\/\/doi.org\/10.1111\/jcmm.18511)"},{"key":"bib54","series-title":"Front Cell Dev Biol","article-title":"Upregulated bone morphogenetic protein 8A (BMP8A) in triple negative breast cancer (TNBC) and its involvement in the bone metastasis","volume":"12","author":"Sui L","year":"2024","unstructured":"Sui L\n, \nCong Y\n, \nLiu M\n, et al.\n Upregulated bone morphogenetic protein 8A (BMP8A) in triple negative breast cancer (TNBC) and its involvement in the bone metastasis. Front Cell Dev Biol 2024 12 1374269. (https:\/\/doi.org\/10.3389\/fcell.2024.1374269)"},{"key":"bib55","series-title":"Nat Commun","first-page":"5196","article-title":"Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer","volume":"12","author":"Wu K","year":"2021","unstructured":"Wu K\n, \nFeng J\n, \nLyu F\n, et al.\n Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer. Nat Commun 2021 12 5196. (https:\/\/doi.org\/10.1038\/s41467-021-25473-y)"},{"key":"bib56","series-title":"CA Cancer J Clin","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung H","year":"2021","unstructured":"Sung H\n, \nFerlay J\n, \nSiegel RL\n, et al.\n Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021 71 209\u2013249. (https:\/\/doi.org\/10.3322\/caac.21660)"},{"key":"bib57","series-title":"Clin Transl Med","first-page":"30","article-title":"Sites of synchronous distant metastases and prognosis in prostate cancer patients with bone metastases at initial diagnosis: a population-based study of 16,643 patients","volume":"8","author":"Zhao F","year":"2019","unstructured":"Zhao F\n, \nWang J\n, \nChen M\n, et al.\n Sites of synchronous distant metastases and prognosis in prostate cancer patients with bone metastases at initial diagnosis: a population-based study of 16,643 patients. Clin Transl Med 2019 8 30. (https:\/\/doi.org\/10.1186\/s40169-019-0247-4)"},{"key":"bib58","series-title":"Cell Death Dis","first-page":"502","article-title":"Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1","volume":"14","author":"Luo JQ","year":"2023","unstructured":"Luo JQ\n, \nYang TW\n, \nWu J\n, et al.\n Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1. Cell Death Dis 2023 14 502. (https:\/\/doi.org\/10.1038\/s41419-023-06007-4)"},{"key":"bib59","series-title":"Nature","first-page":"S49","article-title":"Breast cancer","volume":"485","author":"Grayson M","year":"2012","unstructured":"Grayson M\n\n. Breast cancer. Nature 2012 485 S49. (https:\/\/doi.org\/10.1038\/485s49a)"},{"key":"bib60","series-title":"Proc Natl Acad Sci U S A","first-page":"1124","article-title":"Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival","volume":"107","author":"Gjerdrum C","year":"2010","unstructured":"Gjerdrum C\n, \nTiron C\n, \nHoiby T\n, et al.\n Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. Proc Natl Acad Sci U S A 2010 107 1124\u20131129. (https:\/\/doi.org\/10.1073\/pnas.0909333107)"},{"key":"bib61","series-title":"Cell Mol Life Sci","first-page":"287","article-title":"Fibroblasts activated by miRs-185-5p, miR-652-5p, and miR-1246 shape the tumor microenvironment in triple-negative breast cancer via PATZ1 downregulation","volume":"82","author":"De Luca G","year":"2025","unstructured":"De Luca G\n, \nPetrillo G\n, \nScognamiglio I\n, et al.\n Fibroblasts activated by miRs-185-5p, miR-652-5p, and miR-1246 shape the tumor microenvironment in triple-negative breast cancer via PATZ1 downregulation. Cell Mol Life Sci 2025 82 287. (https:\/\/doi.org\/10.1007\/s00018-025-05781-y)"},{"key":"bib62","series-title":"Comput Struct Biotechnol J","first-page":"2745","article-title":"Deregulated molecules and pathways in the predisposition and dissemination of breast cancer cells to bone","volume":"20","author":"Sui L","year":"2022","unstructured":"Sui L\n, \nSanders A\n, \nJiang WG\n, et al.\n Deregulated molecules and pathways in the predisposition and dissemination of breast cancer cells to bone. Comput Struct Biotechnol J 2022 20 2745\u20132758. (https:\/\/doi.org\/10.1016\/j.csbj.2022.05.051)"},{"key":"bib63","series-title":"Oncogene","first-page":"204","article-title":"Notch3 promotes prostate cancer-induced bone lesion development via MMP-3","volume":"39","author":"Ganguly SS","year":"2020","unstructured":"Ganguly SS\n, \nHostetter G\n, \nTang L\n, et al.\n Notch3 promotes prostate cancer-induced bone lesion development via MMP-3. Oncogene 2020 39 204\u2013218. (https:\/\/doi.org\/10.1038\/s41388-019-0977-1)"},{"key":"bib64","series-title":"Bone","article-title":"CD8(+) T cells from experimental in situ breast carcinoma interfere with bone homeostasis","volume":"150","author":"Monteiro AC","year":"2021","unstructured":"Monteiro AC\n & \nBonomo A\n\n. CD8(+) T cells from experimental in situ breast carcinoma interfere with bone homeostasis. Bone 2021 150 116014. (https:\/\/doi.org\/10.1016\/j.bone.2021.116014)"},{"key":"bib65","series-title":"Arch Biochem Biophys","article-title":"Bone metastatic mammary tumor cell-derived extracellular vesicles inhibit osteoblast maturation via JNK signaling","volume":"750","author":"Uehara N","year":"2023","unstructured":"Uehara N\n, \nShibusawa N\n, \nMikami Y\n, et al.\n Bone metastatic mammary tumor cell-derived extracellular vesicles inhibit osteoblast maturation via JNK signaling. Arch Biochem Biophys 2023 750 109821. (https:\/\/doi.org\/10.1016\/j.abb.2023.109821)"},{"key":"bib66","series-title":"Theranostics","first-page":"929","article-title":"Suppression of breast cancer-associated bone loss with osteoblast proteomes via Hsp90ab1\/moesin-mediated inhibition of TGF\u03b2\/FN1\/CD44 signaling","volume":"12","author":"Sun X","year":"2022","unstructured":"Sun X\n, \nLi K\n, \nHase M\n, et al.\n Suppression of breast cancer-associated bone loss with osteoblast proteomes via Hsp90ab1\/moesin-mediated inhibition of TGF\u03b2\/FN1\/CD44 signaling. Theranostics 2022 12 929\u2013943. (https:\/\/doi.org\/10.7150\/thno.66148)"},{"key":"bib67","series-title":"Sci Rep","first-page":"9104","article-title":"Prognosis of prostate cancer and bone metastasis pattern of patients: a SEER-based study and a local hospital based study from China","volume":"10","author":"Liu D","year":"2020","unstructured":"Liu D\n, \nKuai Y\n, \nZhu R\n, et al.\n Prognosis of prostate cancer and bone metastasis pattern of patients: a SEER-based study and a local hospital based study from China. Sci Rep 2020 10 9104. (https:\/\/doi.org\/10.1038\/s41598-020-64073-6)"},{"key":"bib68","series-title":"Front Oncol","article-title":"Bone marrow-derived stem cell factor regulates prostate cancer-induced shifts in pre-metastatic niche composition","volume":"12","author":"Foster BM","year":"2022","unstructured":"Foster BM\n, \nShi L\n, \nHarris KS\n, et al.\n Bone marrow-derived stem cell factor regulates prostate cancer-induced shifts in pre-metastatic niche composition. Front Oncol 2022 12 855188. (https:\/\/doi.org\/10.3389\/fonc.2022.855188)"},{"key":"bib69","series-title":"Environ Toxicol","first-page":"425","article-title":"Prostate cancer\u2010secreted CCN3 uses the GSK3\u03b2 and \u03b2\u2010catenin pathways to enhance osteogenic factor levels in osteoblasts","volume":"36","author":"Chen PC","year":"2021","unstructured":"Chen PC\n, \nLiu SC\n, \nLin TH\n, et al.\n Prostate cancer\u2010secreted CCN3 uses the GSK3\u03b2 and \u03b2\u2010catenin pathways to enhance osteogenic factor levels in osteoblasts. Environ Toxicol 2021 36 425\u2013432. (https:\/\/doi.org\/10.1002\/tox.23048)"},{"key":"bib70","series-title":"Clin Transl Med","article-title":"LncRNA nuclear-enriched abundant transcript 1 shuttled by prostate cancer cells-secreted exosomes initiates osteoblastic phenotypes in the bone metastatic microenvironment via miR-205-5p\/runt-related transcription factor 2\/splicing factor proline- and glutamine-rich\/polypyrimidine tract-binding protein 2 axis","volume":"11","author":"Mo C","year":"2021","unstructured":"Mo C\n, \nHuang B\n, \nZhuang J\n, et al.\n LncRNA nuclear-enriched abundant transcript 1 shuttled by prostate cancer cells-secreted exosomes initiates osteoblastic phenotypes in the bone metastatic microenvironment via miR-205-5p\/runt-related transcription factor 2\/splicing factor proline- and glutamine-rich\/polypyrimidine tract-binding protein 2 axis. Clin Transl Med 2021 11 e493. (https:\/\/doi.org\/10.1002\/ctm2.493)"},{"key":"bib71","series-title":"J Extracell Vesicles","article-title":"Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1-targeting miRNA-92a-1-5p","volume":"10","author":"Yu L","year":"2021","unstructured":"Yu L\n, \nSui B\n, \nFan W\n, et al.\n Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1-targeting miRNA-92a-1-5p. J Extracell Vesicles 2021 10 e12056. (https:\/\/doi.org\/10.1002\/jev2.12056)"},{"key":"bib72","series-title":"Int J Mol Sci","first-page":"1285","article-title":"Exosomal miRNAs from prostate cancer impair osteoblast function in mice","volume":"23","author":"Furesi G","year":"2022","unstructured":"Furesi G\n, \nde Jesus Domingues AM\n, \nAlexopoulou D\n, et al.\n Exosomal miRNAs from prostate cancer impair osteoblast function in mice. Int J Mol Sci 2022 23 1285. (https:\/\/doi.org\/10.3390\/ijms23031285)"},{"key":"bib73","series-title":"Trends Cancer","first-page":"112","article-title":"Emerging players in prostate cancer-bone niche communication","volume":"7","author":"Furesi G","year":"2021","unstructured":"Furesi G\n, \nRauner M\n & \nHofbauer LC\n\n. Emerging players in prostate cancer-bone niche communication. Trends Cancer 2021 7 112\u2013121. (https:\/\/doi.org\/10.1016\/j.trecan.2020.09.006)"},{"key":"bib74","series-title":"Drug Resist Updat","article-title":"TGF\u03b2-activated asporin interacts with STMN1 to promote prostate cancer docetaxel chemoresistance and metastasis by upregulating the Wnt\/\u03b2-catenin signaling pathway","volume":"81","author":"Ge S","year":"2025","unstructured":"Ge S\n, \nCen J\n, \nLiu X\n, et al.\n TGF\u03b2-activated asporin interacts with STMN1 to promote prostate cancer docetaxel chemoresistance and metastasis by upregulating the Wnt\/\u03b2-catenin signaling pathway. Drug Resist Updat 2025 81 101227. (https:\/\/doi.org\/10.1016\/j.drup.2025.101227)"},{"key":"bib75","series-title":"Nat Rev Urol","first-page":"268","article-title":"Interactions between androgen and IGF1 axes in prostate tumorigenesis","volume":"22","author":"Adzavon YM","year":"2025","unstructured":"Adzavon YM\n, \nCulig Z\n & \nSun Z\n\n. Interactions between androgen and IGF1 axes in prostate tumorigenesis. Nat Rev Urol 2025 22 268\u2013275. (https:\/\/doi.org\/10.1038\/s41585-024-00942-3)"},{"key":"bib76","series-title":"Proc Natl Acad Sci U S A","article-title":"Prostate cancer-induced endothelial-cell-to-osteoblast transition drives immunosuppression in the bone-tumor microenvironment through Wnt pathway-induced M2 macrophage polarization","volume":"121","author":"Yu G","year":"2024","unstructured":"Yu G\n, \nCorn PG\n, \nMak CSL\n, et al.\n Prostate cancer-induced endothelial-cell-to-osteoblast transition drives immunosuppression in the bone-tumor microenvironment through Wnt pathway-induced M2 macrophage polarization. Proc Natl Acad Sci U S A 2024 121 e2402903121. (https:\/\/doi.org\/10.1073\/pnas.2402903121)"},{"key":"bib77","series-title":"EMBO Rep","article-title":"Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone","volume":"21","author":"Owen KL","year":"2020","unstructured":"Owen KL\n, \nGearing LJ\n, \nZanker DJ\n, et al.\n Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone. EMBO Rep 2020 21 e50162. (https:\/\/doi.org\/10.15252\/embr.202050162)"},{"key":"bib78","series-title":"Exp Biol Med","first-page":"971","article-title":"Human-derived osteoblast-like cells and pericyte-like cells induce distinct metastatic phenotypes in primary breast cancer cells","volume":"246","author":"Mayo V","year":"2021","unstructured":"Mayo V\n, \nBowles AC\n, \nWubker LE\n, et al.\n Human-derived osteoblast-like cells and pericyte-like cells induce distinct metastatic phenotypes in primary breast cancer cells. Exp Biol Med 2021 246 971\u2013985. (https:\/\/doi.org\/10.1177\/1535370220971599)"},{"key":"bib79","series-title":"Cell Res","first-page":"464","article-title":"SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches","volume":"33","author":"Wu Q","year":"2023","unstructured":"Wu Q\n, \nTian P\n, \nHe D\n, et al.\n SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches. Cell Res 2023 33 464\u2013478. (https:\/\/doi.org\/10.1038\/s41422-023-00810-6)"},{"key":"bib80","series-title":"J Exp Clin Cancer Res","first-page":"264","article-title":"Tumor removal limits prostate cancer cell dissemination in bone and osteoblasts induce cancer cell dormancy through focal adhesion kinase","volume":"42","author":"Liu R","year":"2023","unstructured":"Liu R\n, \nSu S\n, \nXing J\n, et al.\n Tumor removal limits prostate cancer cell dissemination in bone and osteoblasts induce cancer cell dormancy through focal adhesion kinase. J Exp Clin Cancer Res 2023 42 264. (https:\/\/doi.org\/10.1186\/s13046-023-02849-0)"},{"key":"bib81","series-title":"Nat Cancer","first-page":"327","article-title":"Bone marrow NG2+\/Nestin+ mesenchymal stem cells drive DTC dormancy via TGF-\u03b22","volume":"2","author":"Nobre AR","year":"2021","unstructured":"Nobre AR\n, \nRisson E\n, \nSingh DK\n, et al.\n Bone marrow NG2+\/Nestin+ mesenchymal stem cells drive DTC dormancy via TGF-\u03b22. Nat Cancer 2021 2 327\u2013339. (https:\/\/doi.org\/10.1038\/s43018-021-00179-8)"},{"key":"bib82","series-title":"Cell Death Dis","first-page":"119","article-title":"Correction to: upregulated osterix promotes invasion and bone metastasis and predicts for a poor prognosis in breast cancer","volume":"13","author":"Yao B","year":"2022","unstructured":"Yao B\n, \nWang J\n, \nQu S\n, et al.\n Correction to: upregulated osterix promotes invasion and bone metastasis and predicts for a poor prognosis in breast cancer. Cell Death Dis 2022 13 119. (https:\/\/doi.org\/10.1038\/s41419-022-04545-x)"},{"key":"bib83","series-title":"J Bone Miner Res","first-page":"1566","article-title":"Osteoblasts generate testosterone from DHEA and activate androgen signaling in prostate cancer cells","volume":"36","author":"Moon HH","year":"2021","unstructured":"Moon HH\n, \nClines KL\n, \nO'Day PJ\n, et al.\n Osteoblasts generate testosterone from DHEA and activate androgen signaling in prostate cancer cells. J Bone Miner Res 2021 36 1566\u20131579. (https:\/\/doi.org\/10.1002\/jbmr.4313)"},{"key":"bib84","series-title":"Int J Mol Sci","first-page":"2477","article-title":"Biological effects of cyclin-dependent kinase inhibitors ribociclib, palbociclib and abemaciclib on breast cancer bone microenvironment","volume":"23","author":"Iuliani M","year":"2022","unstructured":"Iuliani M\n, \nSimonetti S\n, \nRibelli G\n, et al.\n Biological effects of cyclin-dependent kinase inhibitors ribociclib, palbociclib and abemaciclib on breast cancer bone microenvironment. Int J Mol Sci 2022 23 2477. (https:\/\/doi.org\/10.3390\/ijms23052477)"},{"key":"bib85","series-title":"Biomedicines","first-page":"2154","article-title":"Osteoblast secretome modulated by abiraterone treatment affects castration resistant prostate cancer cell proliferation","volume":"10","author":"Iuliani M","year":"2022","unstructured":"Iuliani M\n, \nSimonetti S\n, \nRibelli G\n, et al.\n Osteoblast secretome modulated by abiraterone treatment affects castration resistant prostate cancer cell proliferation. Biomedicines 2022 10 2154. (https:\/\/doi.org\/10.3390\/biomedicines10092154)"},{"key":"bib86","series-title":"Thyroid","first-page":"760","article-title":"Metformin reduces thyroid cancer tumor growth in the metastatic niche of bone by inhibiting osteoblastic RANKL productions","volume":"31","author":"Shin HS","year":"2021","unstructured":"Shin HS\n, \nSun HJ\n, \nWhang YM\n, et al.\n Metformin reduces thyroid cancer tumor growth in the metastatic niche of bone by inhibiting osteoblastic RANKL productions. Thyroid 2021 31 760\u2013771. (https:\/\/doi.org\/10.1089\/thy.2019.0851)"},{"key":"bib87","series-title":"J Exp Clin Cancer Res","first-page":"45","article-title":"Procoxacin bidirectionally inhibits osteoblastic and osteoclastic activity in bone and suppresses bone metastasis of prostate cancer","volume":"42","author":"Kong D","year":"2023","unstructured":"Kong D\n, \nYe C\n, \nZhang C\n, et al.\n Procoxacin bidirectionally inhibits osteoblastic and osteoclastic activity in bone and suppresses bone metastasis of prostate cancer. J Exp Clin Cancer Res 2023 42 45. (https:\/\/doi.org\/10.1186\/s13046-023-02610-7)"},{"key":"bib88","series-title":"Int J Mol Sci","first-page":"2202","article-title":"The cell-specific role of SHP2 in regulating bone homeostasis and regeneration niches","volume":"24","author":"Zhang J","year":"2023","unstructured":"Zhang J\n, \nYe C\n, \nZhu Y\n, et al.\n The cell-specific role of SHP2 in regulating bone homeostasis and regeneration niches. Int J Mol Sci 2023 24 2202. (https:\/\/doi.org\/10.3390\/ijms24032202)"},{"key":"bib89","series-title":"Biomaterials","article-title":"Synergistic combination treatment to break cross talk between cancer cells and bone cells to inhibit progression of bone metastasis","volume":"227","author":"Vijayaraghavalu S","year":"2020","unstructured":"Vijayaraghavalu S\n, \nGao Y\n, \nRahman MT\n, et al.\n Synergistic combination treatment to break cross talk between cancer cells and bone cells to inhibit progression of bone metastasis. Biomaterials 2020 227 119558. (https:\/\/doi.org\/10.1016\/j.biomaterials.2019.119558)"},{"key":"bib90","series-title":"Cancer Discov","first-page":"1968","article-title":"H3.3 G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in giant cell tumor of bone","volume":"10","author":"Khazaei S","year":"2020","unstructured":"Khazaei S\n, \nDe Jay N\n, \nDeshmukh S\n, et al.\n H3.3 G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in giant cell tumor of bone. Cancer Discov 2020 10 1968\u20131987. (https:\/\/doi.org\/10.1158\/2159-8290.cd-20-0461)"},{"key":"bib91","series-title":"Cancers","first-page":"263","article-title":"\u2018Educated\u2019 osteoblasts reduce osteoclastogenesis in a bone-tumor mimetic microenvironment","volume":"13","author":"Kolb AD","year":"2021","unstructured":"Kolb AD\n, \nDai J\n, \nKeller ET\n, et al.\n \u2018Educated\u2019 osteoblasts reduce osteoclastogenesis in a bone-tumor mimetic microenvironment. Cancers 2021 13 263. (https:\/\/doi.org\/10.3390\/cancers13020263)"},{"key":"bib92","series-title":"Endocr Relat Cancer","article-title":"Prostate cancer and bone: clinical presentation and molecular mechanisms","volume":"30","author":"Wells KV","year":"2023","unstructured":"Wells KV\n, \nKrackeler ML\n, \nJathal MK\n, et al.\n Prostate cancer and bone: clinical presentation and molecular mechanisms. Endocr Relat Cancer 2023 30 220360. (https:\/\/doi.org\/10.1530\/erc-22-0360)"},{"key":"bib93","series-title":"Cancers","first-page":"4027","article-title":"The bone microenvironment soil in prostate cancer metastasis: an miRNA approach","volume":"15","author":"Prigol AN","year":"2023","unstructured":"Prigol AN\n, \nRode MP\n, \nda Luz Efe F\n, et al.\n The bone microenvironment soil in prostate cancer metastasis: an miRNA approach. Cancers 2023 15 4027. (https:\/\/doi.org\/10.3390\/cancers15164027)"},{"key":"bib94","series-title":"Adv Healthc Mater","article-title":"Hydroxyapatite-bovine serum albumin-paclitaxel nanoparticles for locoregional treatment of osteosarcoma","volume":"10","author":"Liu Y","year":"2021","unstructured":"Liu Y\n, \nQiao Z\n, \nGao J\n, et al.\n Hydroxyapatite-bovine serum albumin-paclitaxel nanoparticles for locoregional treatment of osteosarcoma. Adv Healthc Mater 2021 10 e2000573. 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