{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:35:35Z","timestamp":1791434135303,"version":"4.3.3"},"reference-count":186,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["eor.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Bone homeostasis, a dynamic equilibrium essential for skeletal development and repair, is coordinately regulated by osteoclasts, osteoblasts, and osteocytes.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Hereditary metabolic bone diseases arise from genetic mutations that impair the function of these key bone cells, disrupting the homeostatic balance.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>This review specifically addresses four prevalent hereditary metabolic bone diseases: osteogenesis imperfecta, Paget\u2019s disease of bone, hypophosphatemic rickets, and osteopetrosis.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Dysfunction in major signaling pathways \u2013 notably the Wnt\/\u03b2-catenin, RANK\/RANKL\/OPG, and TGF-\u03b2\/BMP pathways \u2013 plays a central role in the aberrant bone remodeling underlying these disorders.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Elucidating the molecular mechanisms involving these cells and pathways is fundamental to understanding disease pathogenesis and is crucial for the development of novel therapeutic interventions, presenting significant promise for future research.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1530\/eor-2025-0147","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T11:46:41Z","timestamp":1770205601000},"page":"72-84","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":6,"title":["Current advances of bone homeostasis imbalance in the cause of hereditary metabolic bone diseases"],"prefix":"10.1530","volume":"11","author":[{"given":"Xinyu","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Surgery, Children\u2019s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Children\u2019s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanhe","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Children\u2019s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanyu","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Children\u2019s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8647-4818","authenticated-orcid":true,"given":"Pengfei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Children\u2019s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Nat Rev Endocrinol","first-page":"437","article-title":"Pathogenesis of glucocorticoid-induced osteoporosis and options for treatment","volume":"16","author":"Chotiyarnwong P","year":"2020","unstructured":"Chotiyarnwong P\n & \nMccloskey EV\n\n. 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