{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:42:00Z","timestamp":1788547320430,"version":"build-2803163510"},"reference-count":83,"publisher":"Bioscientifica","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["eor.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>This review summarizes the sclerotic zone's pathophysiology, characterization, formation process, and impact on femoral head necrosis.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>The sclerotic zone is a reaction interface formed during the repair of femoral head necrosis.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Compared with normal bone tissue, the mechanical properties of the sclerotic zone are significantly enhanced.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Many factors influence the formation of the sclerotic zone, including mechanics, bone metabolism, angiogenesis, and other biological processes.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>The sclerotic zone plays an essential role in preventing the collapse of the femoral head and can predict the risk of the collapse of the femoral head.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Regulating the formation of the sclerotic zone of the femoral head has become a direction worthy of study in treating femoral head necrosis.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1530\/eor-22-0092","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T08:12:54Z","timestamp":1686211974000},"page":"451-458","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":8,"title":["Sclerotic zone in femoral head necrosis: from pathophysiology to therapeutic implications"],"prefix":"10.1530","volume":"8","author":[{"given":"Pengqiang","family":"Lou","sequence":"first","affiliation":[{"name":"Liaoning University of Traditional Chinese Medicine, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzhi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Liaoning University of Traditional Chinese Medicine, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wei","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Deng","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1461-2134","authenticated-orcid":true,"given":"Decai","family":"Hou","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Journal of the American Academy of Orthopaedic Surgeons","first-page":"455","article-title":"Osteonecrosis of the femoral head: evaluation and treatment","volume":"22","author":"Zalavras","year":"2014","unstructured":"Zalavras CG & Lieberman Jr. Osteonecrosis of the femoral head: evaluation and treatment. 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