{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:18Z","timestamp":1784557038318,"version":"3.55.0"},"reference-count":40,"publisher":"Bioscientifica","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["eor.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>\u2018Damage control\u2019 is the therapeutic strategy in the treatment of polytraumatized patients and aims at securing vital functions and controlling bleeding with a favorable effect on the post-traumatic immune response.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>The post-traumatic immune dysfunction is based on a disturbed balance between immunostimulatory and anti-inflammatory mechanisms. The extent of the immunological \u2018second hit\u2019 can be limited by delaying deferable surgical therapies until organ stabilization has been achieved by the treating surgeon.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Pelvic sling is easy to apply and noninvasive with effective pelvic reduction. Pelvic angiography vs pelvic packing are not antagonistic, but rather should be considered as complementary methods.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Operating as early as possible on unstable spinal injuries with confirmed or suspected neurological deficits by decompression and stabilization with a dorsal internal fixator.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Dislocations, unstable or open fracture, vascular involvement, and compartment syndrome are considered emergency indications. In extremity fracture treatment, primary definitive osteosynthesis is often dispensed with and instead, temporary stabilization with an external fixator is performed.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1530\/eor-23-0046","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T08:09:15Z","timestamp":1683619755000},"page":"372-381","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":9,"title":["The sequence of the treatment of combined fractures of the pelvis, spine, and extremities in polytraumatized patients"],"prefix":"10.1530","volume":"8","author":[{"given":"Cora Rebecca","family":"Schindler","sequence":"first","affiliation":[{"name":"Department of Trauma-, Hand and Reconstructive Surgery, University Hospital Frankfurt, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona","family":"Sturm","sequence":"additional","affiliation":[{"name":"Department of Trauma-, Hand and Reconstructive Surgery, University Hospital Frankfurt, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason Alexander","family":"H\u00f6rauf","sequence":"additional","affiliation":[{"name":"Department of Trauma-, Hand and Reconstructive Surgery, University Hospital Frankfurt, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3677-2910","authenticated-orcid":true,"given":"Ingo","family":"Marzi","sequence":"additional","affiliation":[{"name":"Department of Trauma-, Hand and Reconstructive Surgery, University Hospital Frankfurt, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"St\u00f6rmann","sequence":"additional","affiliation":[{"name":"Department of Trauma-, Hand and Reconstructive Surgery, University Hospital Frankfurt, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"TraumaRegister DGU\u00ae","author":"H\u00f6fer","year":"2021","unstructured":"H\u00f6fer C & Jahresbericht LR. 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