{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:13:34Z","timestamp":1787022814889,"version":"build-2736575974"},"reference-count":47,"publisher":"Bioscientifica","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["eor.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Patients diagnosed with soft tissue sarcoma (STS) present a number of challenges for physicians, due to the vast array of subtypes and aggressive tumor biology.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>There is currently no agreed-upon management strategy for these tumors, which has led to the ongoing debate surrounding how frequently surveillance scans should be performed following surgery. However, advances in multidisciplinary care have improved patient outcomes over recent years.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>The early detection of local recurrence reflects a more aggressive tumor, even in association with the same histopathologic entity.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Treating the local recurrence of extremity STS is a difficult clinical challenge. The goal should be to salvage limbs when possible, with treatments such as resection and irradiation, although amputation may be necessary in some cases. Regional therapies such as high-intensity, low-dose or interleukin-1 receptor antagonist treatment are appealing options for either definitive or adjuvant therapy, depending on the location of the disease\u2019s recurrence.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>The higher survival rate following late recurrence may be explained by variations in tumor biology. Since long-term survival is, in fact, inferior in patients with high-grade STS, this necessitates the implementation of an active surveillance approach.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1530\/eor-23-0095","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T07:02:41Z","timestamp":1690873361000},"page":"606-614","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":22,"title":["Local recurrence management of extremity soft tissue sarcoma"],"prefix":"10.1530","volume":"8","author":[{"given":"Bogdan","family":"Serban","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania"},{"name":"University Emergency Hospital Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7088-883X","authenticated-orcid":true,"given":"Bogdan","family":"Cretu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania"},{"name":"University Emergency Hospital Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Cursaru","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania"},{"name":"University Emergency Hospital Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Nitipir","sequence":"additional","affiliation":[{"name":"Department of Oncology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania"},{"name":"Elias University Emergency Hospital, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Orlov-Slavu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania"},{"name":"Elias University Emergency Hospital, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalin","family":"Cirstoiu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania"},{"name":"University Emergency Hospital Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Advances in Anatomic Pathology","first-page":"44","article-title":"The 2020 WHO classification of tumors of soft tissue: selected changes and new entities","volume":"28","author":"Choi","year":"2021","unstructured":"Choi JH & Ro JY. 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