{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:34:12Z","timestamp":1793691252077,"version":"4.5.1"},"reference-count":77,"publisher":"Bioscientifica","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["eor.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>The pathogenesis of steroid-induced osteonecrosis of the femoral head (SONFH) remains unclear; however, emerging evidence suggests that mitochondrial injury plays a significant role.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>This review aims to elucidate the involvement of mitochondrial dysfunction in SONFH and explore potential therapeutic targets.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>A comprehensive literature search was conducted in PubMed, Web of Science, and Elsevier ScienceDirect, focusing on mitochondrial homeostasis, including mitophagy, mitochondrial biogenesis, mitochondrial dynamics, and oxidative stress in SONFH. Ultimately, we included and analyzed a total of 16 studies.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Glucocorticoids initially promote but later inhibit mitochondrial biogenesis in osteoblasts, leading to excessive ROS production and mitochondrial dysfunction. This dysfunction impairs osteoblast survival and bone formation, contributing to SONFH progression.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Key proteins such as mitochondrial transcription factor A (TFAM) and peroxisome proliferator-activated receptor \u03b3 coactivator 1-\u03b1 (PGC1\u03b1) are potential therapeutic targets for promoting mitochondrial biogenesis and reducing ROS-induced damage.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Enhancing mitochondrial function and reducing oxidative stress in osteoblasts may prevent or slow the progression of SONFH. Future research should focus on developing these strategies.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1530\/eor-24-0023","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T08:58:44Z","timestamp":1731056324000},"page":"1013-1022","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":14,"title":["Mitochondrial maintenance as a novel target for treating steroid-induced osteonecrosis of femoral head: a narrative review"],"prefix":"10.1530","volume":"9","author":[{"given":"Yidan","family":"Yang","sequence":"first","affiliation":[{"name":"Henan University of Chinese Medicine, Zhengzhou, Henan Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine, Zhengzhou, Henan Province, People\u2019s Republic of China"},{"name":"Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoxiao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People\u2019s Republic of China"},{"name":"Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4863-0864","authenticated-orcid":true,"given":"Chen","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Annals of the Rheumatic Diseases","first-page":"325","article-title":"EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis","volume":"69","author":"Peters","year":"2010","unstructured":"Peters MJSymmons DPMcCarey DDijkmans BANicola PKvien TKMcInnes IBHaentzschel HGonzalez-Gay MAProvan S, et al. EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis. Annals of the Rheumatic Diseases 2010 69 325\u2013331. (https:\/\/doi.org\/10.1136\/ard.2009.113696)"},{"key":"bib2","series-title":"Journal of the American Academy of Dermatology","first-page":"1","article-title":"Prevention and management of glucocorticoid-induced side effects: a comprehensive review: a review of glucocorticoid pharmacology and bone health","volume":"76","author":"Caplan","year":"2017","unstructured":"Caplan AFett NRosenbach MWerth VP & Micheletti RG. Prevention and management of glucocorticoid-induced side effects: a comprehensive review: a review of glucocorticoid pharmacology and bone health. Journal of the American Academy of Dermatology 2017 76 1\u20139. (https:\/\/doi.org\/10.1016\/j.jaad.2016.01.062)"},{"key":"bib3","series-title":"Autoimmunity Reviews","first-page":"721","article-title":"Steroid induced osteonecrosis: an analysis of steroid dosing risk","volume":"9","author":"Powell","year":"2010","unstructured":"Powell CChang CNaguwa SMCheema G & Gershwin ME. Steroid induced osteonecrosis: an analysis of steroid dosing risk. Autoimmunity Reviews 2010 9 721\u2013743. (https:\/\/doi.org\/10.1016\/j.autrev.2010.06.007)"},{"key":"bib4","series-title":"Chinese Medical Journal","first-page":"2843","article-title":"Prevalence of nontraumatic osteonecrosis of the femoral head and its associated risk factors in the Chinese population: results from a nationally representative survey","volume":"128","author":"Zhao","year":"2015","unstructured":"Zhao DWYu MHu KWang WYang LWang BJGao XHGuo YMXu YQWei YS, et al. Prevalence of nontraumatic osteonecrosis of the femoral head and its associated risk factors in the Chinese population: results from a nationally representative survey. Chinese Medical Journal 2015 128 2843\u20132850. (https:\/\/doi.org\/10.4103\/0366-6999.168017)"},{"key":"bib5","series-title":"Clinical Orthopaedics and Related Research","first-page":"617","article-title":"Treatment of femoral head osteonecrosis in the United States: 16-year analysis of the nationwide inpatient sample","volume":"472","author":"Johnson","year":"2014","unstructured":"Johnson AJMont MATsao AK & Jones LC. Treatment of femoral head osteonecrosis in the United States: 16-year analysis of the nationwide inpatient sample. Clinical Orthopaedics and Related Research 2014 472 617\u2013623. (https:\/\/doi.org\/10.1007\/s11999-013-3220-3)"},{"key":"bib6","series-title":"Journal of Autoimmunity","first-page":"102460","article-title":"The pathogenesis, diagnosis and clinical manifestations of steroid-induced osteonecrosis","volume":"110","author":"Chang","year":"2020","unstructured":"Chang CGreenspan A & Gershwin ME. The pathogenesis, diagnosis and clinical manifestations of steroid-induced osteonecrosis. Journal of Autoimmunity 2020 110 102460. (https:\/\/doi.org\/10.1016\/j.jaut.2020.102460)"},{"key":"bib7","series-title":"Endocrinology","first-page":"3817","article-title":"The pathophysiological sequence of glucocorticoid-induced osteonecrosis of the femoral head in male mice","volume":"158","author":"Weinstein","year":"2017","unstructured":"Weinstein RSHogan EABorrelli MJLiachenko SO\u2019Brien CA & Manolagas SC. The pathophysiological sequence of glucocorticoid-induced osteonecrosis of the femoral head in male mice. Endocrinology 2017 158 3817\u20133831. (https:\/\/doi.org\/10.1210\/en.2017-00662)"},{"key":"bib8","series-title":"International Journal of Biological Sciences","first-page":"156","article-title":"Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse","volume":"14","author":"Wang","year":"2018","unstructured":"Wang CMeng HWang YZhao BZhao CSun WZhu YHan BYuan XLiu R, et al. Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse. International Journal of Biological Sciences 2018 14 156\u2013164. (https:\/\/doi.org\/10.7150\/ijbs.18334)"},{"key":"bib9","series-title":"Journal of Orthopaedic Translation","first-page":"100","article-title":"Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version)","volume":"21","author":"Zhao","year":"2020","unstructured":"Zhao DZhang FWang BLiu BLi LKim SYGoodman SBHernigou PCui QLineaweaver WC, et al. Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version). Journal of Orthopaedic Translation 2020 21 100\u2013110. (https:\/\/doi.org\/10.1016\/j.jot.2019.12.004)"},{"key":"bib10","series-title":"International Journal of Molecular Sciences","first-page":"1376","article-title":"Osteoporosis due to hormone imbalance: an overview of the effects of estrogen deficiency and glucocorticoid overuse on bone turnover","volume":"23","author":"Cheng","year":"2022","unstructured":"Cheng CHChen LR & Chen KH. Osteoporosis due to hormone imbalance: an overview of the effects of estrogen deficiency and glucocorticoid overuse on bone turnover. International Journal of Molecular Sciences 2022 23 1376. (https:\/\/doi.org\/10.3390\/ijms23031376)"},{"key":"bib11","series-title":"International Journal of Medical Sciences","first-page":"205","article-title":"Mitochondrial stress and redox failure in steroid-associated osteonecrosis","volume":"15","author":"Tsuchiya","year":"2018","unstructured":"Tsuchiya MIchiseki TUeda SUeda YShimazaki MKaneuji A & Kawahara N. Mitochondrial stress and redox failure in steroid-associated osteonecrosis. International Journal of Medical Sciences 2018 15 205\u2013209. (https:\/\/doi.org\/10.7150\/ijms.22525)"},{"key":"bib12","series-title":"Diabetes","first-page":"1728","article-title":"Drp1-mediated mitochondrial abnormalities link to synaptic injury in diabetes model","volume":"64","author":"Huang","year":"2015","unstructured":"Huang SWang YGan XFang DZhong CWu LHu GSosunov AAMcKhann GMYu H, et al. Drp1-mediated mitochondrial abnormalities link to synaptic injury in diabetes model. Diabetes 2015 64 1728\u20131742. (https:\/\/doi.org\/10.2337\/db14-0758)"},{"key":"bib13","series-title":"Annual Review of Pathology","first-page":"235","article-title":"Mitochondrial dynamics and its involvement in disease","volume":"15","author":"Chan","year":"2020","unstructured":"Chan DC. Mitochondrial dynamics and its involvement in disease. Annual Review of Pathology 2020 15 235\u2013259. (https:\/\/doi.org\/10.1146\/annurev-pathmechdis-012419-032711)"},{"key":"bib14","series-title":"Particle and Fibre Toxicology","first-page":"16","article-title":"Carbon black suppresses the osteogenesis of mesenchymal stem cells: the role of mitochondria","volume":"15","author":"Shen","year":"2018","unstructured":"Shen YWu LQin DXia YZhou ZZhang X & Wu X. Carbon black suppresses the osteogenesis of mesenchymal stem cells: the role of mitochondria. Particle and Fibre Toxicology 2018 15 16. (https:\/\/doi.org\/10.1186\/s12989-018-0253-5)"},{"key":"bib15","series-title":"Stem Cell Research and Therapy","first-page":"589","article-title":"PINK1 deficiency impairs osteoblast differentiation through aberrant mitochondrial homeostasis","volume":"12","author":"Lee","year":"2021","unstructured":"Lee SYAn HJKim JMSung MJKim DKKim HKOh JJeong HYLee YHYang T, et al. PINK1 deficiency impairs osteoblast differentiation through aberrant mitochondrial homeostasis. Stem Cell Research and Therapy 2021 12 589. (https:\/\/doi.org\/10.1186\/s13287-021-02656-4)"},{"key":"bib16","series-title":"Drug Design, Development and Therapy","first-page":"973","article-title":"Sulforaphane reverses glucocorticoid-induced apoptosis in osteoblastic cells through regulation of the Nrf2 pathway","volume":"8","author":"Lin","year":"2014","unstructured":"Lin HWei BLi GZheng JSun JChu JZeng R & Niu Y. Sulforaphane reverses glucocorticoid-induced apoptosis in osteoblastic cells through regulation of the Nrf2 pathway. Drug Design, Development and Therapy 2014 8 973\u2013982. (https:\/\/doi.org\/10.2147\/DDDT.S65410)"},{"key":"bib17","series-title":"Food and Function","first-page":"7830","article-title":"Allicin inhibits osteoblast apoptosis and steroid-induced necrosis of femoral head progression by activating the PI3K\/AKT pathway","volume":"11","author":"Zhan","year":"2020","unstructured":"Zhan JYan ZZhao MQi WLin JLin ZHuang YPan X & Xue X. Allicin inhibits osteoblast apoptosis and steroid-induced necrosis of femoral head progression by activating the PI3K\/AKT pathway. Food and Function 2020 11 7830\u20137841. (https:\/\/doi.org\/10.1039\/d0fo00837k)"},{"key":"bib18","series-title":"Research Integrity and Peer Review","first-page":"5","article-title":"SANRA-a scale for the quality assessment of narrative review articles","volume":"4","author":"Baethge","year":"2019","unstructured":"Baethge CGoldbeck-Wood S & Mertens S. SANRA-a scale for the quality assessment of narrative review articles. Research Integrity and Peer Review 2019 4 5. (https:\/\/doi.org\/10.1186\/s41073-019-0064-8)"},{"key":"bib19","series-title":"Nature Cell Biology","first-page":"745","article-title":"The multifaceted contributions of mitochondria to cellular metabolism","volume":"20","author":"Spinelli","year":"2018","unstructured":"Spinelli JB & Haigis MC. The multifaceted contributions of mitochondria to cellular metabolism. Nature Cell Biology 2018 20 745\u2013754. (https:\/\/doi.org\/10.1038\/s41556-018-0124-1)"},{"key":"bib20","series-title":"Nature Reviews. Molecular Cell Biology","first-page":"872","article-title":"Mitochondrial fusion and fission in cell life and death","volume":"11","author":"Westermann","year":"2010","unstructured":"Westermann B. Mitochondrial fusion and fission in cell life and death. Nature Reviews. Molecular Cell Biology 2010 11 872\u2013884. (https:\/\/doi.org\/10.1038\/nrm3013)"},{"key":"bib21","series-title":"Nucleic Acids Research","first-page":"1640","article-title":"Human mitochondrial DNA is packaged with TFAM","volume":"31","author":"Alam","year":"2003","unstructured":"Alam TIKanki TMuta TUkaji KAbe YNakayama HTakio KHamasaki N & Kang D. Human mitochondrial DNA is packaged with TFAM. Nucleic Acids Research 2003 31 1640\u20131645. (https:\/\/doi.org\/10.1093\/nar\/gkg251)"},{"key":"bib22","series-title":"Disease Models and Mechanisms","first-page":"dmm048912","article-title":"Mitochondrial function in development and disease","volume":"14","author":"Rossmann","year":"2021","unstructured":"Rossmann MPDubois SMAgarwal S & Zon LI. Mitochondrial function in development and disease. Disease Models and Mechanisms 2021 14 dmm048912. (https:\/\/doi.org\/10.1242\/dmm.048912)"},{"key":"bib23","series-title":"Cell Metabolism","first-page":"207","article-title":"Redox homeostasis and mitochondrial dynamics","volume":"22","author":"Willems","year":"2015","unstructured":"Willems PHMRossignol RDieteren CEJMurphy MP & Koopman WJH. Redox homeostasis and mitochondrial dynamics. Cell Metabolism 2015 22 207\u2013218. (https:\/\/doi.org\/10.1016\/j.cmet.2015.06.006)"},{"key":"bib24","series-title":"Frontiers in Cell and Developmental Biology","first-page":"467","article-title":"Mitophagy, mitochondrial homeostasis, and cell fate","volume":"8","author":"Ma","year":"2020","unstructured":"Ma KChen GLi WKepp OZhu Y & Chen Q. Mitophagy, mitochondrial homeostasis, and cell fate. Frontiers in Cell and Developmental Biology 2020 8 467. (https:\/\/doi.org\/10.3389\/fcell.2020.00467)"},{"key":"bib25","series-title":"Developmental Cell","first-page":"881","article-title":"Quality control of the mitochondrion","volume":"56","author":"Ng","year":"2021","unstructured":"Ng MYWWai T & Simonsen A. Quality control of the mitochondrion. Developmental Cell 2021 56 881\u2013905. (https:\/\/doi.org\/10.1016\/j.devcel.2021.02.009)"},{"key":"bib26","series-title":"Bone","first-page":"117074","article-title":"Elucidating the role of the GC\/GR\/GLUT1 axis in steroid-induced osteonecrosis of the femoral head: a proteomic approach","volume":"183","author":"Luo","year":"2024","unstructured":"Luo HWei JWu SZheng QLin X & Chen P. Elucidating the role of the GC\/GR\/GLUT1 axis in steroid-induced osteonecrosis of the femoral head: a proteomic approach. Bone 2024 183 117074. (https:\/\/doi.org\/10.1016\/j.bone.2024.117074)"},{"key":"bib27","series-title":"Frontiers in Endocrinology","first-page":"1341366","article-title":"Identification and analysis of mitochondria-related central genes in steroid-induced osteonecrosis of the femoral head, along with drug prediction","volume":"15","author":"Ma","year":"2024","unstructured":"Ma ZSun JJiang QZhao YJiang HSun P & Feng W. Identification and analysis of mitochondria-related central genes in steroid-induced osteonecrosis of the femoral head, along with drug prediction. Frontiers in Endocrinology 2024 15 1341366. (https:\/\/doi.org\/10.3389\/fendo.2024.1341366)"},{"key":"bib28","series-title":"Molecular Medicine Reports","first-page":"3751","article-title":"Salidroside inhibits steroid-induced avascular necrosis of the femoral head via the PI3K\/Akt signaling pathway: in vitro and in vivo studies","volume":"17","author":"Xue","year":"2018","unstructured":"Xue XHFeng ZHLi ZX & Pan XY. Salidroside inhibits steroid-induced avascular necrosis of the femoral head via the PI3K\/Akt signaling pathway: in vitro and in vivo studies. Molecular Medicine Reports 2018 17 3751\u20133757. (https:\/\/doi.org\/10.3892\/mmr.2017.8349)"},{"key":"bib29","series-title":"Frontiers in Pharmacology","first-page":"1195","article-title":"The protective effect of luteolin in glucocorticoid-induced osteonecrosis of the femoral head","volume":"11","author":"Yan","year":"2020","unstructured":"Yan ZZhan JQi WLin JHuang YXue X & Pan X. The protective effect of luteolin in glucocorticoid-induced osteonecrosis of the femoral head. Frontiers in Pharmacology 2020 11 1195. (https:\/\/doi.org\/10.3389\/fphar.2020.01195)"},{"key":"bib30","series-title":"International Journal of Biological Sciences","first-page":"1888","article-title":"Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts","volume":"16","author":"Chen","year":"2020","unstructured":"Chen KLiu YHe JPavlos NWang CKenny JYuan JZhang QXu J & He W. Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts. International Journal of Biological Sciences 2020 16 1888\u20131900. (https:\/\/doi.org\/10.7150\/ijbs.40917)"},{"key":"bib31","series-title":"International Journal of Medical Sciences","first-page":"1375","article-title":"Resistance of bone marrow mesenchymal stem cells in a stressed environment - comparison with osteocyte cells","volume":"18","author":"Shimasaki","year":"2021","unstructured":"Shimasaki MUeda SIchiseki THirata HKawahara N & Ueda Y. Resistance of bone marrow mesenchymal stem cells in a stressed environment - comparison with osteocyte cells. International Journal of Medical Sciences 2021 18 1375\u20131381. (https:\/\/doi.org\/10.7150\/ijms.52104)"},{"key":"bib32","series-title":"International Orthopaedics","first-page":"1729","article-title":"Animal models of steroid-induced osteonecrosis of the femoral head-a comprehensive research review up to 2018","volume":"42","author":"Xu","year":"2018","unstructured":"Xu JGong HLu SDeasey MJ & Cui Q. Animal models of steroid-induced osteonecrosis of the femoral head-a comprehensive research review up to 2018. International Orthopaedics 2018 42 1729\u20131737. (https:\/\/doi.org\/10.1007\/s00264-018-3956-1)"},{"key":"bib33","series-title":"Cell Death and Disease","first-page":"42","article-title":"P53 and Parkin co-regulate mitophagy in bone marrow mesenchymal stem cells to promote the repair of early steroid-induced osteonecrosis of the femoral head","volume":"11","author":"Zhang","year":"2020","unstructured":"Zhang FPeng WZhang JDong WWu JWang T & Xie Z. P53 and Parkin co-regulate mitophagy in bone marrow mesenchymal stem cells to promote the repair of early steroid-induced osteonecrosis of the femoral head. Cell Death and Disease 2020 11 42. (https:\/\/doi.org\/10.1038\/s41419-020-2238-1)"},{"key":"bib34","series-title":"Journal of Cellular Physiology","first-page":"9864","article-title":"Desferoxamine protects against glucocorticoid-induced osteonecrosis of the femoral head via activating HIF-1alpha expression","volume":"235","author":"Jing","year":"2020","unstructured":"Jing XDu TYang XZhang WWang GLiu XLi T & Jiang Z. Desferoxamine protects against glucocorticoid-induced osteonecrosis of the femoral head via activating HIF-1alpha expression. Journal of Cellular Physiology 2020 235 9864\u20139875. (https:\/\/doi.org\/10.1002\/jcp.29799)"},{"key":"bib35","series-title":"Cell Death and Differentiation","first-page":"229","article-title":"SIRT3\/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress","volume":"25","author":"Gao","year":"2018","unstructured":"Gao JFeng ZWang XZeng MLiu JHan SXu JChen LCao KLong J, et al. SIRT3\/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress. Cell Death and Differentiation 2018 25 229\u2013240. (https:\/\/doi.org\/10.1038\/cdd.2017.144)"},{"key":"bib36","series-title":"BMC Musculoskeletal Disorders","first-page":"277","article-title":"Decreased angiogenic and increased apoptotic activities of bone microvascular endothelial cells in patients with glucocorticoid-induced osteonecrosis of the femoral head","volume":"21","author":"Yu","year":"2020","unstructured":"Yu HLiu PZuo WSun XLiu HLu FGuo W & Zhang Q. Decreased angiogenic and increased apoptotic activities of bone microvascular endothelial cells in patients with glucocorticoid-induced osteonecrosis of the femoral head. BMC Musculoskeletal Disorders 2020 21 277. (https:\/\/doi.org\/10.1186\/s12891-020-03225-1)"},{"key":"bib37","series-title":"Veterinary Pathology","first-page":"345","article-title":"Osteonecrosis of the femoral head of laboratory animals: the lessons learned from a comparative study of osteonecrosis in man and experimental animals","volume":"40","author":"Boss","year":"2003","unstructured":"Boss JH & Misselevich I. Osteonecrosis of the femoral head of laboratory animals: the lessons learned from a comparative study of osteonecrosis in man and experimental animals. Veterinary Pathology 2003 40 345\u2013354. (https:\/\/doi.org\/10.1354\/vp.40-4-345)"},{"key":"bib38","series-title":"Journal of Cellular Physiology","first-page":"1475","article-title":"P53 dependent mitochondrial permeability transition pore opening is required for dexamethasone-induced death of osteoblasts","volume":"229","author":"Zhen","year":"2014","unstructured":"Zhen YFWang GDZhu LQTan SPZhang FYZhou XZ & Wang XD. P53 dependent mitochondrial permeability transition pore opening is required for dexamethasone-induced death of osteoblasts. Journal of Cellular Physiology 2014 229 1475\u20131483. (https:\/\/doi.org\/10.1002\/jcp.24589)"},{"key":"bib39","series-title":"Biochemical and Biophysical Research Communications","first-page":"149","article-title":"Dexamethasone induces ferroptosis via P53\/SLC7A11\/GPX4 pathway in glucocorticoid-induced osteonecrosis of the femoral head","volume":"602","author":"Sun","year":"2022","unstructured":"Sun FZhou JLLiu ZLJiang ZW & Peng H. Dexamethasone induces ferroptosis via P53\/SLC7A11\/GPX4 pathway in glucocorticoid-induced osteonecrosis of the femoral head. Biochemical and Biophysical Research Communications 2022 602 149\u2013155. (https:\/\/doi.org\/10.1016\/j.bbrc.2022.02.112)"},{"key":"bib40","series-title":"Stem Cell Research and Therapy","first-page":"171","article-title":"Exogenous melatonin ameliorates steroid-induced osteonecrosis of the femoral head by modulating ferroptosis through GDF15-mediated signaling","volume":"14","author":"Li","year":"2023","unstructured":"Li WLi WZhang WWang HYu LYang PQin YGan MYang XHuang L, et al. Exogenous melatonin ameliorates steroid-induced osteonecrosis of the femoral head by modulating ferroptosis through GDF15-mediated signaling. Stem Cell Research and Therapy 2023 14 171. (https:\/\/doi.org\/10.1186\/s13287-023-03371-y)"},{"key":"bib41","series-title":"Journal of Biological Chemistry","first-page":"44326","article-title":"Glucocorticoids and tumor necrosis factor \u03b1 increase oxidative stress and suppress Wnt protein signaling in osteoblasts","volume":"286","author":"Almeida","year":"2011","unstructured":"Almeida MHan LAmbrogini EWeinstein RS & Manolagas SC. Glucocorticoids and tumor necrosis factor \u03b1 increase oxidative stress and suppress Wnt protein signaling in osteoblasts. Journal of Biological Chemistry 2011 286 44326\u201344335. (https:\/\/doi.org\/10.1074\/jbc.M111.283481)"},{"key":"bib42","series-title":"Chinese Medical Journal","first-page":"134","article-title":"Glucocorticoids affect the metabolism of bone marrow stromal cells and lead to osteonecrosis of the femoral head: a review","volume":"125","author":"Tan","year":"2012","unstructured":"Tan GKang PD & Pei FX. Glucocorticoids affect the metabolism of bone marrow stromal cells and lead to osteonecrosis of the femoral head: a review. Chinese Medical Journal 2012 125 134\u2013139."},{"key":"bib43","series-title":"eLife","first-page":"RP92469","article-title":"\u03b2-catenin inhibition disrupts the homeostasis of osteogenic\/adipogenic differentiation leading to the development of glucocorticoid-induced osteonecrosis of the femoral head","volume":"12","author":"Xia","year":"2024","unstructured":"Xia CXu HFang LChen JYuan WFu DWang XHe BXiao LWu C, et al. \u03b2-catenin inhibition disrupts the homeostasis of osteogenic\/adipogenic differentiation leading to the development of glucocorticoid-induced osteonecrosis of the femoral head. eLife 2024 12 RP92469. (https:\/\/doi.org\/10.7554\/eLife.92469)"},{"key":"bib44","series-title":"Nature Cell Biology","first-page":"1013","article-title":"Mechanisms of mitophagy in cellular homeostasis, physiology and pathology","volume":"20","author":"Palikaras","year":"2018","unstructured":"Palikaras KLionaki E & Tavernarakis N. Mechanisms of mitophagy in cellular homeostasis, physiology and pathology. Nature Cell Biology 2018 20 1013\u20131022. (https:\/\/doi.org\/10.1038\/s41556-018-0176-2)"},{"key":"bib45","series-title":"Current Biology","first-page":"R170","article-title":"Mitophagy and quality control mechanisms in mitochondrial maintenance","volume":"28","author":"Pickles","year":"2018","unstructured":"Pickles SVigie P & Youle RJ. Mitophagy and quality control mechanisms in mitochondrial maintenance. Current Biology 2018 28 R170\u2013R185. (https:\/\/doi.org\/10.1016\/j.cub.2018.01.004)"},{"key":"bib46","series-title":"Biochimica et Biophysica Acta","first-page":"1186","article-title":"p53 and mitochondrial function in neurons","volume":"1842","author":"Wang","year":"2014","unstructured":"Wang DBKinoshita CKinoshita Y & Morrison RS. p53 and mitochondrial function in neurons. Biochimica et Biophysica Acta 2014 1842 1186\u20131197. (https:\/\/doi.org\/10.1016\/j.bbadis.2013.12.015)"},{"key":"bib47","series-title":"Life Sciences","first-page":"36","article-title":"Mitophagy is a protective response against oxidative damage in bone marrow mesenchymal stem cells","volume":"229","author":"Fan","year":"2019","unstructured":"Fan PYu XYXie XHChen CHZhang PYang CPeng X & Wang YT. Mitophagy is a protective response against oxidative damage in bone marrow mesenchymal stem cells. Life Sciences 2019 229 36\u201345. (https:\/\/doi.org\/10.1016\/j.lfs.2019.05.027)"},{"key":"bib48","series-title":"Cell and Tissue Research","first-page":"111","article-title":"Mitochondrial quality control by the Pink1\/Parkin system","volume":"367","author":"R\u00fcb","year":"2017","unstructured":"R\u00fcb CWilkening A & Voos W. Mitochondrial quality control by the Pink1\/Parkin system. Cell and Tissue Research 2017 367 111\u2013123. (https:\/\/doi.org\/10.1007\/s00441-016-2485-8)"},{"key":"bib49","series-title":"PNAS","first-page":"6400","article-title":"The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo","volume":"110","author":"Vincow","year":"2013","unstructured":"Vincow ESMerrihew GThomas REShulman NJBeyer RPMacCoss MJ & Pallanck LJ. The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo. PNAS 2013 110 6400\u20136405. (https:\/\/doi.org\/10.1073\/pnas.1221132110)"},{"key":"bib50","series-title":"Molecular Neurodegeneration","first-page":"20","article-title":"PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson\u2019s disease","volume":"15","author":"Ge","year":"2020","unstructured":"Ge PDawson VL & Dawson TM. PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson\u2019s disease. Molecular Neurodegeneration 2020 15 20. (https:\/\/doi.org\/10.1186\/s13024-020-00367-7)"},{"key":"bib51","series-title":"Redox Biology","first-page":"666","article-title":"Loss of Parkin reduces inflammatory arthritis by inhibiting p53 degradation","volume":"12","author":"Jung","year":"2017","unstructured":"Jung YYSon DJLee HLKim DHSong MJHam YWKim YHan SBPark MH & Hong JT. Loss of Parkin reduces inflammatory arthritis by inhibiting p53 degradation. Redox Biology 2017 12 666\u2013673. (https:\/\/doi.org\/10.1016\/j.redox.2017.04.007)"},{"key":"bib52","series-title":"Environmental Toxicology","first-page":"2123","article-title":"Overexpression of HIF-1alpha enhances the protective effect of mitophagy on steroid-induced osteocytes apoptosis","volume":"36","author":"Xu","year":"2021","unstructured":"Xu KLu CRen XWang JXu P & Zhang Y. Overexpression of HIF-1alpha enhances the protective effect of mitophagy on steroid-induced osteocytes apoptosis. Environmental Toxicology 2021 36 2123\u20132137. (https:\/\/doi.org\/10.1002\/tox.23327)"},{"key":"bib53","series-title":"Frontiers in Pharmacology","first-page":"1209","article-title":"Vitamin K2 can rescue the dexamethasone-induced downregulation of osteoblast autophagy and mitophagy thereby restoring osteoblast function in vitro and in vivo","volume":"11","author":"Chen","year":"2020","unstructured":"Chen LShi XWeng SJXie JTang JHYan DYWang BZXie ZJWu ZY & Yang L. Vitamin K2 can rescue the dexamethasone-induced downregulation of osteoblast autophagy and mitophagy thereby restoring osteoblast function in vitro and in vivo. Frontiers in Pharmacology 2020 11 1209. (https:\/\/doi.org\/10.3389\/fphar.2020.01209)"},{"key":"bib54","series-title":"Protein and Cell","first-page":"439","article-title":"The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells","volume":"8","author":"Li","year":"2017","unstructured":"Li QGao ZChen Y & Guan MX. The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells. Protein and Cell 2017 8 439\u2013445. (https:\/\/doi.org\/10.1007\/s13238-017-0385-7)"},{"key":"bib55","series-title":"Chinese Journal of Physiology","first-page":"286","article-title":"Glucocorticoid transiently upregulates mitochondrial biogenesis in the osteoblast","volume":"63","author":"Hsu","year":"2020","unstructured":"Hsu CNJen CYChen YHPeng SYWu SC & Yao CL. Glucocorticoid transiently upregulates mitochondrial biogenesis in the osteoblast. Chinese Journal of Physiology 2020 63 286\u2013293. (https:\/\/doi.org\/10.4103\/CJP.CJP_51_20)"},{"key":"bib56","series-title":"Annual Review of Biochemistry","first-page":"685","article-title":"Mitochondrial machineries for protein import and assembly","volume":"86","author":"Wiedemann","year":"2017","unstructured":"Wiedemann N & Pfanner N. Mitochondrial machineries for protein import and assembly. Annual Review of Biochemistry 2017 86 685\u2013714. (https:\/\/doi.org\/10.1146\/annurev-biochem-060815-014352)"},{"key":"bib57","series-title":"International Journal of Medical Sciences","first-page":"1293","article-title":"Mitochondrial transcription factor A added to osteocytes in a stressed environment has a cytoprotective Effect","volume":"17","author":"Ueda","year":"2020","unstructured":"Ueda SShimasaki MIchiseki THirata HKawahara N & Ueda Y. Mitochondrial transcription factor A added to osteocytes in a stressed environment has a cytoprotective Effect. International Journal of Medical Sciences 2020 17 1293\u20131299. (https:\/\/doi.org\/10.7150\/ijms.45335)"},{"key":"bib58","series-title":"International Journal of Molecular Sciences","first-page":"6892","article-title":"Taurine inhibits glucocorticoid-induced bone mitochondrial injury, preventing osteonecrosis in rabbits and cultured osteocytes","volume":"21","author":"Hirata","year":"2020","unstructured":"Hirata HUeda SIchiseki TShimasaki MUeda YKaneuji A & Kawahara N. Taurine inhibits glucocorticoid-induced bone mitochondrial injury, preventing osteonecrosis in rabbits and cultured osteocytes. International Journal of Molecular Sciences 2020 21 6892. (https:\/\/doi.org\/10.3390\/ijms21186892)"},{"key":"bib59","series-title":"Journal of Cellular and Molecular Medicine","first-page":"4892","article-title":"Mitochondrial biogenesis: an update","volume":"24","author":"Popov","year":"2020","unstructured":"Popov LD. Mitochondrial biogenesis: an update. Journal of Cellular and Molecular Medicine 2020 24 4892\u20134899. (https:\/\/doi.org\/10.1111\/jcmm.15194)"},{"key":"bib60","series-title":"Biochemical Pharmacology","first-page":"34","article-title":"The osteogenic effect of liraglutide involves enhanced mitochondrial biogenesis in osteoblasts","volume":"164","author":"Pal","year":"2019","unstructured":"Pal SMaurya SKChattopadhyay SPal China SPorwal KKulkarni CSanyal SSinha RA & Chattopadhyay N. The osteogenic effect of liraglutide involves enhanced mitochondrial biogenesis in osteoblasts. Biochemical Pharmacology 2019 164 34\u201344. (https:\/\/doi.org\/10.1016\/j.bcp.2019.03.024)"},{"key":"bib61","series-title":"Drug Design, Development and Therapy","first-page":"4451","article-title":"Resveratrol protects osteoblasts against dexamethasone-induced cytotoxicity through activation of AMP-activated protein kinase","volume":"14","author":"Wang","year":"2020","unstructured":"Wang LLi QYan HJiao GWang HChi HZhou HChen LShan Y & Chen Y. Resveratrol protects osteoblasts against dexamethasone-induced cytotoxicity through activation of AMP-activated protein kinase. Drug Design, Development and Therapy 2020 14 4451\u20134463. (https:\/\/doi.org\/10.2147\/DDDT.S266502)"},{"key":"bib62","series-title":"International Journal of Molecular Sciences","first-page":"10195","article-title":"A neuroprotective bovine colostrum attenuates apoptosis in dexamethasone-treated MC3T3-E1 osteoblastic cells","volume":"22","author":"Martin-Aragon","year":"2021","unstructured":"Martin-Aragon SBermejo-Bescos PBenedi JRaposo CMarques FKydonaki EKGkiata PKoutedakis YNtina GCarrillo AE, et al. A neuroprotective bovine colostrum attenuates apoptosis in dexamethasone-treated MC3T3-E1 osteoblastic cells. International Journal of Molecular Sciences 2021 22 10195. (https:\/\/doi.org\/10.3390\/ijms221910195)"},{"key":"bib63","series-title":"Cell Reports","first-page":"2932","article-title":"Sphingosine kinase activates the mitochondrial unfolded protein response and is targeted to mitochondria by stress","volume":"24","author":"Kim","year":"2018","unstructured":"Kim S & Sieburth D. Sphingosine kinase activates the mitochondrial unfolded protein response and is targeted to mitochondria by stress. Cell Reports 2018 24 2932\u20132945.e4. (https:\/\/doi.org\/10.1016\/j.celrep.2018.08.037)"},{"key":"bib64","series-title":"Cell","first-page":"548","article-title":"Mitochondrial fusion protects against neurodegeneration in the cerebellum","volume":"130","author":"Chen","year":"2007","unstructured":"Chen HMcCaffery JM & Chan DC. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 2007 130 548\u2013562. (https:\/\/doi.org\/10.1016\/j.cell.2007.06.026)"},{"key":"bib65","series-title":"New England Journal of Medicine","first-page":"2236","article-title":"Mitochondrial dynamics--mitochondrial fission and fusion in human diseases","volume":"369","author":"Archer","year":"2013","unstructured":"Archer SL. Mitochondrial dynamics--mitochondrial fission and fusion in human diseases. New England Journal of Medicine 2013 369 2236\u20132251. (https:\/\/doi.org\/10.1056\/NEJMra1215233)"},{"key":"bib66","series-title":"Stem Cell Research and Therapy","first-page":"140","article-title":"PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway","volume":"11","author":"Yao","year":"2020","unstructured":"Yao XYu SJing XGuo JSun KGuo F & Ye Y. PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway. Stem Cell Research and Therapy 2020 11 140. (https:\/\/doi.org\/10.1186\/s13287-020-01658-y)"},{"key":"bib67","series-title":"Biochemical and Biophysical Research Communications","first-page":"719","article-title":"Blockade of Drp1 rescues oxidative stress-induced osteoblast dysfunction","volume":"468","author":"Gan","year":"2015","unstructured":"Gan XHuang SYu QYu H & Yan SS. Blockade of Drp1 rescues oxidative stress-induced osteoblast dysfunction. Biochemical and Biophysical Research Communications 2015 468 719\u2013725. (https:\/\/doi.org\/10.1016\/j.bbrc.2015.11.022)"},{"key":"bib68","series-title":"Journal of Bone and Mineral Research","first-page":"2122","article-title":"Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine","volume":"28","author":"Xia","year":"2013","unstructured":"Xia WFJung JUShun CXiong SXiong LShi XMMei L & Xiong WC. Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine. Journal of Bone and Mineral Research 2013 28 2122\u20132135. (https:\/\/doi.org\/10.1002\/jbmr.1954)"},{"key":"bib69","series-title":"Cell Death and Disease","first-page":"1077","article-title":"APP promotes osteoblast survival and bone formation by regulating mitochondrial function and preventing oxidative stress","volume":"9","author":"Pan","year":"2018","unstructured":"Pan JXTang FXiong FXiong LZeng PWang BZhao KGuo HShun CXia WF, et al. APP promotes osteoblast survival and bone formation by regulating mitochondrial function and preventing oxidative stress. Cell Death and Disease 2018 9 1077. (https:\/\/doi.org\/10.1038\/s41419-018-1123-7)"},{"key":"bib70","series-title":"Natural Product Reports","first-page":"109","article-title":"Natural product-derived pharmacological modulators of Nrf2\/ARE pathway for chronic diseases","volume":"31","author":"Kumar","year":"2014","unstructured":"Kumar HKim ISMore SVKim BW & Choi DK. Natural product-derived pharmacological modulators of Nrf2\/ARE pathway for chronic diseases. Natural Product Reports 2014 31 109\u2013139. (https:\/\/doi.org\/10.1039\/c3np70065h)"},{"key":"bib71","series-title":"Annual Review of Pharmacology and Toxicology","first-page":"89","article-title":"Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway","volume":"47","author":"Kensler","year":"2007","unstructured":"Kensler TWWakabayashi N & Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annual Review of Pharmacology and Toxicology 2007 47 89\u2013116. (https:\/\/doi.org\/10.1146\/annurev.pharmtox.46.120604.141046)"},{"key":"bib72","series-title":"Nucleic Acids Research","first-page":"5718","article-title":"Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis","volume":"38","author":"Malhotra","year":"2010","unstructured":"Malhotra DPortales-Casamar ESingh ASrivastava SArenillas DHappel CShyr CWakabayashi NKensler TWWasserman WW, et al. Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Research 2010 38 5718\u20135734. (https:\/\/doi.org\/10.1093\/nar\/gkq212)"},{"key":"bib73","series-title":"Toxicological Sciences","first-page":"391","article-title":"The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos","volume":"115","author":"Shi","year":"2010","unstructured":"Shi X & Zhou B. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Toxicological Sciences 2010 115 391\u2013400. (https:\/\/doi.org\/10.1093\/toxsci\/kfq066)"},{"key":"bib74","series-title":"Cell Death and Disease","first-page":"940","article-title":"PARK7 promotes repair in early steroid-induced osteonecrosis of the femoral head by enhancing resistance to stress-induced apoptosis in bone marrow mesenchymal stem cells via regulation of the Nrf2 signaling pathway","volume":"12","author":"Zhang","year":"2021","unstructured":"Zhang FYan YPeng WWang LWang TXie ZLuo HZhang J & Dong W. PARK7 promotes repair in early steroid-induced osteonecrosis of the femoral head by enhancing resistance to stress-induced apoptosis in bone marrow mesenchymal stem cells via regulation of the Nrf2 signaling pathway. Cell Death and Disease 2021 12 940. (https:\/\/doi.org\/10.1038\/s41419-021-04226-1)"},{"key":"bib75","series-title":"Antioxidants and Redox Signaling","first-page":"686","article-title":"Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications","volume":"22","author":"Apostolova","year":"2015","unstructured":"Apostolova N & Victor VM. Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications. Antioxidants and Redox Signaling 2015 22 686\u2013729. (https:\/\/doi.org\/10.1089\/ars.2014.5952)"},{"key":"bib76","series-title":"Journal of Pineal Research","first-page":"253","article-title":"Melatonin as an antioxidant: under promises but over delivers","volume":"61","author":"Reiter","year":"2016","unstructured":"Reiter RJMayo JCTan DXSainz RMAlatorre-Jimenez M & Qin L. Melatonin as an antioxidant: under promises but over delivers. Journal of Pineal Research 2016 61 253\u2013278. (https:\/\/doi.org\/10.1111\/jpi.12360)"},{"key":"bib77","series-title":"Oxidative Medicine and Cellular Longevity","first-page":"4019619","article-title":"Melatonin increases bone mass around the prostheses of OVX rats by ameliorating mitochondrial oxidative stress via the SIRT3\/SOD2 signaling pathway","volume":"2019","author":"Zhou","year":"2019","unstructured":"Zhou WLiu YShen JYu BBai JLin JGuo XSun HChen ZYang H, et al. Melatonin increases bone mass around the prostheses of OVX rats by ameliorating mitochondrial oxidative stress via the SIRT3\/SOD2 signaling pathway. Oxidative Medicine and Cellular Longevity 2019 2019 4019619. 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