{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:39:29Z","timestamp":1790282369217,"version":"4.1.0"},"reference-count":31,"publisher":"Bioscientifica","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["eor.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>The best treatment of unicameral bone cyst and aneurismatic bone cyst (ABC) is debated in the literature.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>For simple bone cysts, multiple treatments were proposed from observation only to open curettage. The historical treatment with intraosseous injection of methylprednisolone acetate into the bone cysts nowadays is reduced due to the morbidity of multiple injections and the risk of multiple pathologic fractures until the healing.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Different types of treatments for ABC are reported, including surgery, percutaneous treatments, and medical treatments; however, there is currently no consensus on the best approach. The association of curettage, bone graft, and elastic stable intramedullary nail (ESIN) had a success rate of over 85%. Decompressing the cyst wall is more critical for increasing the healing rate than the type of graft used to fill the cavity.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>In ABC, sclerotherapy offers the advantages of lower invasiveness and morbidity, associated with better functional scores and faster return to full weight-bearing. Moreover, they can be used in challenging locations.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Selective arterial embolization is a complex procedure and often requires association with other treatments. Further studies are needed to confirm the effectiveness of denosumab and its side effects on skeletally immature patients. Curettage with adjuvants and autogenous bone grafting still shows promising results and can be used in larger, aggressive defects or superficial lesions.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>For simple bone cysts, the combination of curettage, bone graft, and ESIN showed the best results. Sclerotherapy for ABC also shows promising results.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1530\/eor-24-0027","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T07:05:25Z","timestamp":1715324725000},"page":"387-392","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":16,"title":["Modern treatment of unicameral and aneurysmatic bone cysts"],"prefix":"10.1530","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0210-5888","authenticated-orcid":true,"given":"Elisa","family":"Pala","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Trovarelli","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Angelini","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Cerchiaro","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9617-9882","authenticated-orcid":true,"given":"Pietro","family":"Ruggieri","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"World Health Organization Classification of Tumours","article-title":"Soft tissue and bone tumours-aneurysmal bone cyst","volume":"6","year":"2020","unstructured":"WHO Classification of Tumours EditorialBoard. Soft tissue and bone tumours-aneurysmal bone cyst. World Health Organization Classification of Tumours, vol. 6, 5th ed. Lyon: International Agency for Research on Cancer, 2020."},{"key":"bib2","series-title":"Journal of Pediatric Orthopedics","first-page":"e68","article-title":"Current trends and variations in the treatment of unicameral bone cysts of the humerus: a survey of EPOS and POSNA members","volume":"40","author":"Farr","year":"2020","unstructured":"Farr SSpencer Balac\u00f3 IMSMart\u00ednez-Alvarez SHahne J & Bae DS. Current trends and variations in the treatment of unicameral bone cysts of the humerus: a survey of EPOS and POSNA members. Journal of Pediatric Orthopedics202040e68\u2013e76. (https:\/\/doi.org\/10.1097\/BPO.0000000000001376)"},{"key":"bib3","series-title":"JBJS Reviewers","first-page":"e23.00159","article-title":"Treatment and Outcomes of 4973 unicameral bpne cysts","volume":"12","author":"Ruiz-Arellanos","year":"2024","unstructured":"Ruiz-Arellanos KLarios FInchaustegui MIGonzalez MR & Pretell-Mazzini J. Treatment and Outcomes of 4973 unicameral bpne cysts. JBJS Reviewers202412e23.00159. (https:\/\/doi.org\/10.2106\/JBJS.RVW.23.00159)"},{"key":"bib4","series-title":"Wiener Klinische Wochenschrift","article-title":"Open surgical treatment of unicameral bone cysts a retrospective","author":"D\u00f6ring","year":"2023","unstructured":"D\u00f6ring KSturz GDHobusch GPuchner SWindhager R & Chiari C. Open surgical treatment of unicameral bone cysts a retrospective data analysis. Wiener Klinische Wochenschrift2023. (https:\/\/doi.org\/10.1007\/s00508-023-02267-4)"},{"key":"bib5","series-title":"Journal of Pediatric Orthopedics","first-page":"108","article-title":"Simple bone cysts: better with age?","volume":"35","author":"Donaldson","year":"2015","unstructured":"Donaldson S & Wright JG. Simple bone cysts: better with age?Journal of Pediatric Orthopedics201535108\u2013114. (https:\/\/doi.org\/10.1097\/BPO.0000000000000336)"},{"key":"bib6","series-title":"Journal of Bone and Joint Surgery","first-page":"200","article-title":"The effects of methylprednisolone acetate in the treatment of bone cysts. Results of three years follow-up","volume":"61-B","author":"Scaglietti","year":"1979","unstructured":"Scaglietti OMarchetti PG & Bartolozzi P. The effects of methylprednisolone acetate in the treatment of bone cysts. Results of three years follow-up. Journal of Bone and Joint Surgery197961-B200\u2013204. (https:\/\/doi.org\/10.1302\/0301-620X.61B2.438272)"},{"key":"bib7","series-title":"Journal of Bone and Joint Surgery","first-page":"1493","article-title":"Etiology of simple bone cyst","volume":"52","author":"Cohen","year":"1970","unstructured":"Cohen J. Etiology of simple bone cyst. Journal of Bone and Joint Surgery1970521493\u20131497. (https:\/\/doi.org\/10.2106\/00004623-197052070-00030)"},{"key":"bib8","series-title":"Current Opinion in Pediatrics","first-page":"131","article-title":"The treatment of aneurysmal bone cysts","volume":"35","author":"van Geloven","year":"2023","unstructured":"van Geloven TPGvan de Sande MAJ & van der Heijden L. The treatment of aneurysmal bone cysts. Current Opinion in Pediatrics202335131\u2013137. (https:\/\/doi.org\/10.1097\/MOP.0000000000001205)"},{"key":"bib9","series-title":"Journal of Clinical Medicine","first-page":"7213","article-title":"Efficacy of percutaneous treatment of primary aneurysmal bone cysts (ABCs): a systematic review and meta-analysis","volume":"12","author":"Samargandi","year":"2023","unstructured":"Samargandi RAlkameshki MBarnawi MAlzahrani KIskander ONicolas QHetaimish BBerhouet J & Le Nail LR. Efficacy of percutaneous treatment of primary aneurysmal bone cysts (ABCs): a systematic review and meta-analysis. Journal of Clinical Medicine2023127213. (https:\/\/doi.org\/10.3390\/jcm12237213)"},{"key":"bib10","series-title":"Journal of Orthopaedics","first-page":"265","article-title":"Is sclerotherapy with polidocanol a better treatment option for aneurysmal bone cyst compared to conventional curettage and bone grafting?","volume":"25","author":"Puthoor","year":"2021","unstructured":"Puthoor DFrancis L & Ismail R. Is sclerotherapy with polidocanol a better treatment option for aneurysmal bone cyst compared to conventional curettage and bone grafting?Journal of Orthopaedics202125265\u2013270. (https:\/\/doi.org\/10.1016\/j.jor.2021.05.020)"},{"key":"bib11","series-title":"Bone and Joint Open","first-page":"125","article-title":"Efficacy of treatment interventions for primary & aneurysmal bone cysts: a systematic review","volume":"2","author":"Bavan","year":"2021","unstructured":"Bavan LWijendra A & Kothari A. Efficacy of treatment interventions for primary & aneurysmal bone cysts: a systematic review. Bone and Joint Open20212125\u2013133. (https:\/\/doi.org\/10.1302\/2633-1462.22.BJO-2020-0168)"},{"key":"bib12","series-title":"A&A Practice","first-page":"e01424","article-title":"Severe acute lung injury after H2O2 irrigation of an aneurysmal bone cyst in an 8-year-old girl: a case report","volume":"15","author":"Waldvogel","year":"2021","unstructured":"Waldvogel SZutter AKrieg AH & Trachsel D. Severe acute lung injury after H2O2 irrigation of an aneurysmal bone cyst in an 8-year-old girl: a case report. A&A Practice202115e01424. (https:\/\/doi.org\/10.1213\/XAA.0000000000001424)"},{"key":"bib13","series-title":"European Journal of Orthopaedic Surgery and Traumatology","first-page":"1287","article-title":"Percutaneous treatments of primary aneurysmal bone cysts: systematic review and meta-analysis","volume":"31","author":"Cruz","year":"2021","unstructured":"Cruz GSCuevas-Su\u00e1rez CESaavedra JPAGiorgis RTeixeira MRK & Muniz FWMG. Percutaneous treatments of primary aneurysmal bone cysts: systematic review and meta-analysis. European Journal of Orthopaedic Surgery and Traumatology2021311287\u20131295. (https:\/\/doi.org\/10.1007\/s00590-021-02893-6)"},{"key":"bib14","series-title":"Clinical Orthopaedics and Related Research","first-page":"2675","article-title":"Percutaneous doxycycline treatment of aneurysmal bone cysts with low recurrence rate: a preliminary report","volume":"471","author":"Shiels","year":"2013","unstructured":"Shiels WE & Mayerson JL. Percutaneous doxycycline treatment of aneurysmal bone cysts with low recurrence rate: a preliminary report. Clinical Orthopaedics and Related Research20134712675\u20132683. (https:\/\/doi.org\/10.1007\/s11999-013-3043-2)"},{"key":"bib15","series-title":"Acta Orthopaedica","first-page":"502","article-title":"Sclerotherapy with polidocanol for treatment of aneurysmal bone cysts","volume":"84","author":"Brosj\u00f6","year":"2013","unstructured":"Brosj\u00f6 OPechon PHesla ATsagozis P & Bauer H. Sclerotherapy with polidocanol for treatment of aneurysmal bone cysts. Acta Orthopaedica201384502\u2013505. (https:\/\/doi.org\/10.3109\/17453674.2013.850013)"},{"key":"bib16","series-title":"Journal of Pediatric Orthopedics","first-page":"e555","article-title":"Efficacy of sclerotherapy with polidocanol (ethoxysclerol) in primary aneurysmal bone cysts in children and adolescents","volume":"41","author":"Jasper","year":"2021","unstructured":"Jasper Jvander Heijden Lvan Rijswijk CSP& van de Sande MAJ. Efficacy of sclerotherapy with polidocanol (ethoxysclerol) in primary aneurysmal bone cysts in children and adolescents. Journal of Pediatric Orthopedics202141e555\u2013e562. (https:\/\/doi.org\/10.1097\/BPO.0000000000001839)"},{"key":"bib17","series-title":"World Journal of Orthopedics","first-page":"698","article-title":"Sclerotherapy as a primary or salvage procedure for aneurysmal bone cysts: a single-center experience","volume":"14","author":"Weber","year":"2023","unstructured":"Weber KSJensen CL & Petersen MM. Sclerotherapy as a primary or salvage procedure for aneurysmal bone cysts: a single-center experience. World Journal of Orthopedics202314698\u2013706. (https:\/\/doi.org\/10.5312\/wjo.v14.i9.698)"},{"key":"bib18","series-title":"Journal of Orthopaedics","first-page":"143","article-title":"Polidocanol sclerotherapy for the treatment of aneurysmal bone cyst, with or without pathological fractures: a prospective, comparative study","volume":"46","author":"Ahmad","year":"2023","unstructured":"Ahmad SAlam IKhan AQAbbas MB & Chowdhry M. Polidocanol sclerotherapy for the treatment of aneurysmal bone cyst, with or without pathological fractures: a prospective, comparative study. Journal of Orthopaedics202346143\u2013149. (https:\/\/doi.org\/10.1016\/j.jor.2023.10.022)"},{"key":"bib19","series-title":"International Orthopaedics","first-page":"1685","article-title":"How effective is embolization with N-2-butyl-cyanoacrylate for aneurysmal bone cysts?","volume":"41","author":"Rossi","year":"2017","unstructured":"Rossi GMavrogenis AFFacchini GBartalena TRimondi ERenzulli MAndreone ADurante SAngelini A & Errani C. How effective is embolization with N-2-butyl-cyanoacrylate for aneurysmal bone cysts?International Orthopaedics2017411685\u20131692. (https:\/\/doi.org\/10.1007\/s00264-016-3364-3)"},{"key":"bib20","series-title":"European Spine Journal","first-page":"533","article-title":"Aneurysmal bone cyst of the mobile spine: the therapeutic role of embolization","volume":"22","author":"Amendola","year":"2013","unstructured":"Amendola LSimonetti LSimoes CEBandiera SDe Iure F & Boriani S. Aneurysmal bone cyst of the mobile spine: the therapeutic role of embolization. European Spine Journal201322533\u2013541. (https:\/\/doi.org\/10.1007\/s00586-012-2566-7)"},{"key":"bib21","series-title":"Journal of Vascular and Interventional Radiology","first-page":"1425.e2","article-title":"Combined transarterial embo- lization and percutaneous sclerotherapy as treatment for refractory and nonresectable aneurysmal bone cysts","volume":"32","author":"Masthoff","year":"2021","unstructured":"Masthoff MGerwing MSchneider KNK\u00f6hler MDeventer NSchindler PHeindel WHardes JSeidensticker MGosheger G, et al.Combined transarterial embo- lization and percutaneous sclerotherapy as treatment for refractory and nonresectable aneurysmal bone cysts. Journal of Vascular and Interventional Radiology2021321425.e2\u20131434.e2. (https:\/\/doi.org\/10.1016\/j.jvir.2021.07.008)"},{"key":"bib22","series-title":"Journal of Surgical Oncology","first-page":"1428","article-title":"Aneurysmal bone cyst: is selective arterial embolization effective as curettage and bone grafting?","volume":"128","author":"Cevolani","year":"2023","unstructured":"Cevolani LStaals ECampanacci LDozza BMartella CSpinnato PDi Carlo MPeta GDonati DMMiceli M, et al.Aneurysmal bone cyst: is selective arterial embolization effective as curettage and bone grafting?Journal of Surgical Oncology20231281428\u20131436. (https:\/\/doi.org\/10.1002\/jso.27422)"},{"key":"bib23","series-title":"Orthopedic Research and Reviews","first-page":"159","article-title":"Spinal aneurysmal bone cysts (ABCs): optimal management","volume":"11","author":"Parker","year":"2019","unstructured":"Parker JSoltani SBoissiere LObeid IGille O & Kieser DC. Spinal aneurysmal bone cysts (ABCs): optimal management. Orthopedic Research and Reviews201911159\u2013166. (https:\/\/doi.org\/10.2147\/ORR.S211834)"},{"key":"bib24","series-title":"Healthcare","first-page":"2658","article-title":"Aneurysmal bone cyst of the pelvis in children and adolescents: effectiveness of surgical treatment with curettage, cryotherapy and bone grafting","volume":"11","author":"Andreani","year":"2023","unstructured":"Andreani LIpponi ESerrano EDe Franco SCordoni MBechini ED\u2019Arienzo A & Parchi PD. Aneurysmal bone cyst of the pelvis in children and adolescents: effectiveness of surgical treatment with curettage, cryotherapy and bone grafting. Healthcare2023112658. (https:\/\/doi.org\/10.3390\/healthcare11192658)"},{"key":"bib25","series-title":"Clinics in Orthopedic Surgery","first-page":"149","article-title":"Using denosumab as a nonsurgical management of aneurysmal bone cysts in the pelvis","volume":"16","author":"El Masry","year":"2024","unstructured":"El Masry AMAzmy SIMustafa MAR & Abuelhadid MA. Using denosumab as a nonsurgical management of aneurysmal bone cysts in the pelvis. Clinics in Orthopedic Surgery202416149\u2013156. (https:\/\/doi.org\/10.4055\/cios22228)"},{"key":"bib26","series-title":"Journal of Surgical Oncology","first-page":"719","article-title":"Aneurysmal bone cyst: the role of cryosurgery as local adjuvant treatment","volume":"100","author":"Peeters","year":"2009","unstructured":"Peeters SPVan der Geest ICde Rooy JWVeth RP & Schreuder HW. Aneurysmal bone cyst: the role of cryosurgery as local adjuvant treatment. Journal of Surgical Oncology2009100719\u2013724. (https:\/\/doi.org\/10.1002\/jso.21410)"},{"key":"bib27","series-title":"Orthopedics","first-page":"204","article-title":"Denosumab: current use in the treatment of primary bone tumors","volume":"40","author":"Savvidou","year":"2017","unstructured":"Savvidou ODBolia IKChloros GDPapanastasiou JKoutsouradis P & Papagelopoulos PJ. Denosumab: current use in the treatment of primary bone tumors. Orthopedics201740204\u2013210. (https:\/\/doi.org\/10.3928\/01477447-20170627-04)"},{"key":"bib28","series-title":"Spine","first-page":"E1201","article-title":"Response of aneurysmal bone cyst to denosumab","volume":"40","author":"Skubitz","year":"2015","unstructured":"Skubitz KMPeltola JCSantos ER & Cheng EY. Response of aneurysmal bone cyst to denosumab. Spine201540E1201\u2013E1204. (https:\/\/doi.org\/10.1097\/BRS.0000000000001027)"},{"key":"bib29","series-title":"Tumori","first-page":"344","article-title":"Denosumab in patients with aneurysmal bone cysts: a case series with preliminary results","volume":"104","author":"Palmerini","year":"2018","unstructured":"Palmerini ERuggieri PAngelini ABoriani SCampanacci DMilano GMCesari MPaioli ALonghi AAbate ME, et al.Denosumab in patients with aneurysmal bone cysts: a case series with preliminary results. Tumori2018104344\u2013351. (https:\/\/doi.org\/10.1177\/0300891618784808)"},{"key":"bib30","series-title":"Orthopaedics and Traumatology, Surgery and Research","first-page":"1181","article-title":"Denosumab for treating aneurysmal bone cysts in children","volume":"105","author":"Raux","year":"2019","unstructured":"Raux SBouhamama AGaspar NBrugieres LEntz-Werle NMallet CDijoud FGouin F & Marec-B\u00e9rard P. Denosumab for treating aneurysmal bone cysts in children. Orthopaedics and Traumatology, Surgery and Research20191051181\u20131185. (https:\/\/doi.org\/10.1016\/j.otsr.2019.04.028)"},{"key":"bib31","series-title":"Current Osteoporosis Reports","first-page":"283","article-title":"Denosumab: an emerging therapy in pediatric bone disorders","volume":"15","author":"Boyce","year":"2017","unstructured":"Boyce AM. Denosumab: an emerging therapy in pediatric bone disorders. Current Osteoporosis Reports201715283\u2013292. (https:\/\/doi.org\/10.1007\/s11914-017-0380-1)"}],"container-title":["EFORT Open Reviews"],"original-title":[],"link":[{"URL":"https:\/\/eor.bioscientifica.com\/view\/journals\/eor\/9\/5\/EOR-24-0027.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eor.bioscientifica.com\/downloadpdf\/journals\/eor\/9\/5\/EOR-24-0027.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/eor.bioscientifica.com\/downloadpdf\/journals\/eor\/9\/5\/EOR-24-0027.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:51:23Z","timestamp":1784555483000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/eor\/article\/9\/5\/387-392\/2704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,1]]},"references-count":31,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.1530\/eor-24-0027","relation":{},"ISSN":["2058-5241"],"issn-type":[{"value":"2058-5241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,1]]}}}