{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:08:02Z","timestamp":1789517282331,"version":"build-2803163510"},"reference-count":18,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>\n                    An increased association between neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NET) and other second primary malignancies has been suggested. We determined whether there is indeed an increased risk for second primary malignancies in GEP-NET patients compared with an age- and sex-matched control group of patients with identical malignancies. The series comprised 243 men and 216 women, diagnosed with a GEP-NET between 2000 and 2009 in a tertiary referral center. The timeline, before-at-after diagnosis, and the type of other malignancies were studied using person-year methodology. Poisson distributions were used for testing statistical significance. All data were cross-checked with the Dutch National Cancer Registry. Out of 459 patients with GEP-NET, 67 (13.7%) had a second primary cancer diagnosis: 25 previous cancers (5.4%), 13 synchronous cancers (2.8%), and 29 metachronous cancers (6.3%). The most common types of second primary cancer were breast cancer (\n                    <jats:italic>n<\/jats:italic>\n                    =10), colorectal cancer (\n                    <jats:italic>n<\/jats:italic>\n                    =8), melanoma (\n                    <jats:italic>n<\/jats:italic>\n                    =6), and prostate cancer (\n                    <jats:italic>n<\/jats:italic>\n                    =5). The number of patients with a cancer history was lower than expected, although not significant (\n                    <jats:italic>n<\/jats:italic>\n                    =25 vs\n                    <jats:italic>n<\/jats:italic>\n                    =34.5). The diagnosis of synchronous cancers, mainly colorectal tumors, was higher than expected (\n                    <jats:italic>n<\/jats:italic>\n                    =13 vs\n                    <jats:italic>n<\/jats:italic>\n                    =6.1,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). Metachronous tumors occurred as frequent as expected (\n                    <jats:italic>n<\/jats:italic>\n                    =29 vs\n                    <jats:italic>n<\/jats:italic>\n                    =25.2, NS). In conclusion, our results are in contrast to previous studies and demonstrate that only the occurrence of synchronous second primary malignancies, mainly colorectal cancers, is increased in GEP-NET patients compared with the general population.\n                  <\/jats:p>","DOI":"10.1530\/erc-11-0315","type":"journal-article","created":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T22:35:17Z","timestamp":1324593317000},"page":"95-99","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":38,"title":["Occurrence of second primary malignancies in patients with neuroendocrine tumors of the digestive tract and pancreas"],"prefix":"10.1530","volume":"19","author":[{"given":"Kimberly","family":"Kamp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald A M","family":"Damhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A","family":"Feelders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter W","family":"de Herder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"issue":"1","key":"2_38655955","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/sj.bjc.6605989","volume":"104","author":"Bzhalava","year":"2011","journal-title":"British Journal of Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1532-1827","issn-type":"print"},{"issue":"3","key":"3_22132655","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.lungcan.2006.02.004","volume":"52","author":"Cote","year":"2006","journal-title":"Lung cancer (Amsterdam, Netherlands)","ISSN":"https:\/\/id.crossref.org\/issn\/0169-5002","issn-type":"print"},{"issue":"4","key":"4_15842395","first-page":"427","volume":"180","author":"Gerstle","year":"1995","journal-title":"Journal of the American College of Surgeons","ISSN":"https:\/\/id.crossref.org\/issn\/1072-7515","issn-type":"print"},{"issue":"4","key":"5_10586510","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/1096-9098(200012)75:4<306::AID-JSO14>3.0.CO;2-3","volume":"75","author":"Habal","year":"2000","journal-title":"Journal of surgical oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-4790","issn-type":"print"},{"issue":"10","key":"6_31222659","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1093\/annonc\/mdn351","volume":"19","year":"2008","journal-title":"Annals of Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0923-7534","issn-type":"print"},{"issue":"2","key":"7_31175206","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1677\/ERC-07-0221","volume":"15","author":"Halfdanarson","year":"2008","journal-title":"Endocrine-Related Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1351-0088","issn-type":"print"},{"issue":"11","key":"8_37170126","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1093\/jnci\/djq120","volume":"102","year":"2010","journal-title":"JNCI Journal of the National Cancer Institute","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8874","issn-type":"print"},{"issue":"1","key":"9_39332988","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ecl.2010.12.005","volume":"40","author":"Lawrence","year":"2011","journal-title":"Endocrinology and metabolism clinics of North America","ISSN":"https:\/\/id.crossref.org\/issn\/0889-8529","issn-type":"print"},{"key":"10_34857745","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/cncr.23159","volume":"112","year":"2008","ISSN":"https:\/\/id.crossref.org\/issn\/1097-0142","issn-type":"print"},{"issue":"1","key":"11_30240149","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S1470-2045(07)70410-2","volume":"9","author":"Modlin","year":"2008","journal-title":"The lancet oncology","ISSN":"https:\/\/id.crossref.org\/issn\/1470-2045","issn-type":"print"},{"issue":"4","key":"12_37886364","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1677\/ERC-10-0152","volume":"17","year":"2010","journal-title":"Endocrine-Related Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1351-0088","issn-type":"print"},{"issue":"4","key":"13_22629645","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s00428-006-0250-1","volume":"449","author":"Rindi","year":"2006","journal-title":"Virchows Archiv : an international journal of pathology","ISSN":"https:\/\/id.crossref.org\/issn\/0945-6317","issn-type":"print"},{"issue":"4","key":"14_29520015","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/s00428-007-0452-1","volume":"451","author":"Rindi","year":"2007","journal-title":"Virchows Archiv : an international journal of pathology","ISSN":"https:\/\/id.crossref.org\/issn\/0945-6317","issn-type":"print"},{"issue":"6","key":"15_15998047","first-page":"607","volume":"66","author":"Schneider","year":"1995","journal-title":"Der Chirurg; 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