{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:17:27Z","timestamp":1791037047063,"version":"4.1.0"},"reference-count":30,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hypotheses are built upon data, but data require hypotheses before they can be understood. The development of the \u2018two-hit\u2019 hypothesis of carcinogenesis was a key event in cancer genetics because it provided a testable model of how tumours develop. In this commentary on \u2018Promoter hypermethylation patterns in Fallopian tube epithelium of BRCA1 and BRCA2 germline mutation carriers\u2019 by Bijron et al. published in the February 2012 issue of Endocrine-Related Cancer, the need for new grammar and some new hypotheses in epigenetics is discussed. Meanwhile, data suggesting an important role of epigenetic modification in the cause, progression and treatment of cancer continues to accumulate.<\/jats:p>","DOI":"10.1530\/erc-12-0003","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T01:45:36Z","timestamp":1327974336000},"page":"C23-C27","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":1,"title":["Epigenetic modification and cancer: mark or stamp?"],"prefix":"10.1530","volume":"19","author":[{"given":"William D","family":"Foulkes","sequence":"first","affiliation":[{"name":"Program in Cancer Genetics","department":["Departments of Oncology and Human Genetics, 546 Pine Avenue West, McGill University, Montreal, Quebec, Canada H2W 1S6"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2026070909335023900_bib1","doi-asserted-by":"crossref","unstructured":"Bahubeshi\n              A\n            \n            \n              Tischkowitz\n              M\n            \n            \n              Foulkes\n              WD\n            \n          \n          2011\n          miRNA processing and human cancer: DICER1 cuts the mustard. Science Translational Medicine3ps46doi:10.1126\/scitranslmed.3002493.","DOI":"10.1126\/scitranslmed.3002493"},{"key":"2026070909335023900_bib2","doi-asserted-by":"crossref","unstructured":"Baylin\n              SB\n            \n            \n              Belinsky\n              SA\n            \n            \n              Herman\n              JG\n            \n          \n          2000\n          Aberrant methylation of gene promoters in cancer-concepts, misconcepts, and promise. Journal of the National Cancer Institute921460\u20131461. doi:10.1093\/jnci\/92.18.1460.","DOI":"10.1093\/jnci\/92.18.1460"},{"key":"2026070909335023900_bib3","doi-asserted-by":"crossref","unstructured":"Baysal\n              BE\n            \n          \n          2004\n          Genomic imprinting and environment in hereditary paraganglioma. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics129C85\u201390. doi:10.1002\/ajmg.c.30018.","DOI":"10.1002\/ajmg.c.30018"},{"key":"2026070909335023900_bib4","doi-asserted-by":"crossref","unstructured":"Bijron\n              JG\n            \n            \n              van der Groep\n              P\n            \n            \n              van Dorst\n              EB\n            \n            \n              Seeber\n              LM\n            \n            \n              Sie-Go\n              DMDS\n            \n            \n              Verheijen\n              RHM\n            \n            \n              van Diest\n              PJ\n            \n          \n          2012\n          Promoter hypermethylation patterns in Fallopian tube epithelium of BRCA1 and BRCA2 germline mutation carriers. Endocrine-Related Cancer1968\u201381. doi:10.1530\/ERC-11-0338.","DOI":"10.1530\/ERC-11-0338"},{"key":"2026070909335023900_bib5","doi-asserted-by":"crossref","unstructured":"Bol\n              GM\n            \n            \n              Suijkerbuijk\n              KP\n            \n            \n              Bart\n              J\n            \n            \n              Vooijs\n              M\n            \n            \n              van der Wall\n              E\n            \n            \n              van Diest\n              PJ\n            \n          \n          2010\n          Methylation profiles of hereditary and sporadic ovarian cancer. Histopathology57363\u2013370. doi:10.1111\/j.1365-2559.2010.03642.x.","DOI":"10.1111\/j.1365-2559.2010.03642.x"},{"key":"2026070909335023900_bib6","doi-asserted-by":"crossref","unstructured":"Cavenee\n              WK\n            \n            \n              Dryja\n              TP\n            \n            \n              Phillips\n              RA\n            \n            \n              Benedict\n              WF\n            \n            \n              Godbout\n              R\n            \n            \n              Gallie\n              BL\n            \n            \n              Murphree\n              AL\n            \n            \n              Strong\n              LC\n            \n            \n              White\n              RL\n            \n          \n          1983\n          Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature305779\u2013784. doi:10.1038\/305779a0.","DOI":"10.1038\/305779a0"},{"key":"2026070909335023900_bib7","doi-asserted-by":"crossref","unstructured":"Esteller\n              M\n            \n          \n          2007\n          Epigenetic gene silencing in cancer: the DNA hypermethylome. Human Molecular Genetics16R50\u2013R59. doi:10.1093\/hmg\/ddm018.","DOI":"10.1093\/hmg\/ddm018"},{"key":"2026070909335023900_bib8","doi-asserted-by":"crossref","unstructured":"Esteller\n              M\n            \n          \n          2011a\n          Epigenetic changes in cancer. F1000 Biology Reports39doi:10.3410\/B3-9.","DOI":"10.3410\/B3-9"},{"key":"2026070909335023900_bib9","doi-asserted-by":"crossref","unstructured":"Esteller\n              M\n            \n          \n          2011b\n          Non-coding RNAs in human disease. Nature Reviews. Genetics12861\u2013874. doi:10.1038\/nrg3074.","DOI":"10.1038\/nrg3074"},{"key":"2026070909335023900_bib10","doi-asserted-by":"crossref","unstructured":"Esteller\n              M\n            \n            \n              Silva\n              JM\n            \n            \n              Dominguez\n              G\n            \n            \n              Bonilla\n              F\n            \n            \n              Matias-Guiu\n              X\n            \n            \n              Lerma\n              E\n            \n            \n              Bussaglia\n              E\n            \n            \n              Prat\n              J\n            \n            \n              Harkes\n              IC\n            \n            \n              Repasky\n              EA\n            \n            \n          \n          2000\n          Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors [see comments]. Journal of the National Cancer Institute92564\u2013569. doi:10.1093\/jnci\/92.7.564.","DOI":"10.1093\/jnci\/92.7.564"},{"key":"2026070909335023900_bib11","doi-asserted-by":"crossref","unstructured":"Feinberg\n              AP\n            \n          \n          1993\n          Genomic imprinting and gene activation in cancer. Nature Genetics4110\u2013113. doi:10.1038\/ng0693-110.","DOI":"10.1038\/ng0693-110"},{"key":"2026070909335023900_bib12","doi-asserted-by":"crossref","unstructured":"Feinberg\n              AP\n            \n            \n              Vogelstein\n              B\n            \n          \n          1983\n          Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature30189\u201392. doi:10.1038\/301089a0.","DOI":"10.1038\/301089a0"},{"key":"2026070909335023900_bib13","doi-asserted-by":"crossref","unstructured":"Folkins\n              AK\n            \n            \n              Jarboe\n              EA\n            \n            \n              Saleemuddin\n              A\n            \n            \n              Lee\n              Y\n            \n            \n              Callahan\n              MJ\n            \n            \n              Drapkin\n              R\n            \n            \n              Garber\n              JE\n            \n            \n              Muto\n              MG\n            \n            \n              Tworoger\n              S\n            \n            \n              Crum\n              CP\n            \n          \n          2008\n          A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations. Gynecologic Oncology109168\u2013173. doi:10.1016\/j.ygyno.2008.01.012.","DOI":"10.1016\/j.ygyno.2008.01.012"},{"key":"2026070909335023900_bib14","doi-asserted-by":"crossref","unstructured":"Gordon\n              M\n            \n            \n              Baksh\n              S\n            \n          \n          2011\n          RASSF1A: not a prototypical Ras effector. Small GTPases2148\u2013157. doi:10.4161\/sgtp.2.3.16286.","DOI":"10.4161\/sgtp.2.3.16286"},{"key":"2026070909335023900_bib15","doi-asserted-by":"crossref","unstructured":"Henry\n              I\n            \n            \n              Bonaiti-Pellie\n              C\n            \n            \n              Chehensse\n              V\n            \n            \n              Beldjord\n              C\n            \n            \n              Schwartz\n              C\n            \n            \n              Utermann\n              G\n            \n            \n              Junien\n              C\n            \n          \n          1991\n          Uniparental paternal disomy in a genetic cancer-predisposing syndrome. Nature351665\u2013667. doi:10.1038\/351665a0.","DOI":"10.1038\/351665a0"},{"key":"2026070909335023900_bib16","doi-asserted-by":"crossref","unstructured":"Heravi-Moussavi\n              A\n            \n            \n              Anglesio\n              MS\n            \n            \n              Cheng\n              SW\n            \n            \n              Senz\n              J\n            \n            \n              Yang\n              W\n            \n            \n              Prentice\n              L\n            \n            \n              Fejes\n              AP\n            \n            \n              Chow\n              C\n            \n            \n              Tone\n              A\n            \n            \n              Kalloger\n              SE\n            \n            \n          \n          2011\n          Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers. New England Journal of Medicinedoi:10.1056\/NEJMoa1102903.","DOI":"10.1056\/NEJMoa1102903"},{"key":"2026070909335023900_bib17","doi-asserted-by":"crossref","unstructured":"Holm\n              TM\n            \n            \n              Jackson-Grusby\n              L\n            \n            \n              Brambrink\n              T\n            \n            \n              Yamada\n              Y\n            \n            \n              Rideout\n              WM\n              III\n            \n            \n              Jaenisch\n              R\n            \n          \n          2005\n          Global loss of imprinting leads to widespread tumorigenesis in adult mice. Cancer Cell8275\u2013285. doi:10.1016\/j.ccr.2005.09.007.","DOI":"10.1016\/j.ccr.2005.10.006"},{"key":"2026070909335023900_bib18","doi-asserted-by":"crossref","unstructured":"Knudson\n              AG\n              Jr\n            \n          \n          1971\n          Mutation and cancer: statistical study of retinoblastoma. PNAS68820\u2013823. doi:10.1073\/pnas.68.4.820.","DOI":"10.1073\/pnas.68.4.820"},{"key":"2026070909335023900_bib19","unstructured":"Knudson\n              AG\n            \n          \n          1978\n          Retinoblastoma; a prototypic hereditary neoplasm. Seminars in Oncology557\u201360."},{"key":"2026070909335023900_bib20","doi-asserted-by":"crossref","unstructured":"Ligtenberg\n              MJ\n            \n            \n              Kuiper\n              RP\n            \n            \n              Chan\n              TL\n            \n            \n              Goossens\n              M\n            \n            \n              Hebeda\n              KM\n            \n            \n              Voorendt\n              M\n            \n            \n              Lee\n              TY\n            \n            \n              Bodmer\n              D\n            \n            \n              Hoenselaar\n              E\n            \n            \n              Hendriks-Cornelissen\n              SJ\n            \n            \n          \n          2009\n          Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3\u2032 exons of TACSTD1. Nature Genetics41112\u2013117. doi:10.1038\/ng.283.","DOI":"10.1038\/ng.283"},{"key":"2026070909335023900_bib21","doi-asserted-by":"crossref","unstructured":"McGowan\n              PO\n            \n            \n              Sasaki\n              A\n            \n            \n              D'Alessio\n              AC\n            \n            \n              Dymov\n              S\n            \n            \n              Labonte\n              B\n            \n            \n              Szyf\n              M\n            \n            \n              Turecki\n              G\n            \n            \n              Meaney\n              MJ\n            \n          \n          2009\n          Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience12342\u2013348. doi:10.1038\/nn.2270.","DOI":"10.1038\/nn.2270"},{"key":"2026070909335023900_bib22","doi-asserted-by":"crossref","unstructured":"Nicholls\n              RD\n            \n            \n              Knoll\n              JH\n            \n            \n              Butler\n              MG\n            \n            \n              Karam\n              S\n            \n            \n              Lalande\n              M\n            \n          \n          1989\n          Genetic imprinting suggested by maternal heterodisomy in nondeletion Prader\u2013Willi syndrome. Nature342281\u2013285. doi:10.1038\/342281a0.","DOI":"10.1038\/342281a0"},{"key":"2026070909335023900_bib23","doi-asserted-by":"crossref","unstructured":"Scott\n              RH\n            \n            \n              Douglas\n              J\n            \n            \n              Baskcomb\n              L\n            \n            \n              Huxter\n              N\n            \n            \n              Barker\n              K\n            \n            \n              Hanks\n              S\n            \n            \n              Craft\n              A\n            \n            \n              Gerrard\n              M\n            \n            \n              Kohler\n              JA\n            \n            \n              Levitt\n              GA\n            \n            \n          \n          2008\n          Constitutional 11p15 abnormalities, including heritable imprinting center mutations, cause nonsyndromic Wilms tumor. Nature Genetics401329\u20131334. doi:10.1038\/ng.243.","DOI":"10.1038\/ng.243"},{"key":"2026070909335023900_bib24","doi-asserted-by":"crossref","unstructured":"Spofford\n              JB\n            \n          \n          1959\n          Parental control of position-effect variegation: I. Parental heterochromatin and expression of the white locus in compound-X Drosophila melanogaster. PNAS451003\u20131007. doi:10.1073\/pnas.45.7.1003.","DOI":"10.1073\/pnas.45.7.1003"},{"key":"2026070909335023900_bib25","doi-asserted-by":"crossref","unstructured":"Spofford\n              JB\n            \n          \n          1961\n          Parental control of position-effect variegation. II. Effect of sex of parent contributing white-mottled rearrangement in Drosophila melanogaster. Genetics461151\u20131167.","DOI":"10.1093\/genetics\/46.9.1151"},{"key":"2026070909335023900_bib26","doi-asserted-by":"crossref","unstructured":"Suijkerbuijk\n              KP\n            \n            \n              Fackler\n              MJ\n            \n            \n              Sukumar\n              S\n            \n            \n              van Gils\n              CH\n            \n            \n              van\n              LT\n            \n            \n              van der Wall\n              E\n            \n            \n              Vooijs\n              M\n            \n            \n              van Diest\n              PJ\n            \n          \n          2008\n          Methylation is less abundant in BRCA1-associated compared with sporadic breast cancer. Annals of Oncology191870\u20131874. doi:10.1093\/annonc\/mdn409.","DOI":"10.1093\/annonc\/mdn409"},{"key":"2026070909335023900_bib27","doi-asserted-by":"crossref","unstructured":"Szyf\n              M\n            \n            \n              McGowan\n              P\n            \n            \n              Meaney\n              MJ\n            \n          \n          2008\n          The social environment and the epigenome. Environmental and Molecular Mutagenesis4946\u201360. doi:10.1002\/em.20357.","DOI":"10.1002\/em.20357"},{"key":"2026070909335023900_bib28","doi-asserted-by":"crossref","unstructured":"Tomlinson\n              IP\n            \n            \n              Roylance\n              R\n            \n            \n              Houlston\n              RS\n            \n          \n          2001\n          Two hits revisited again. Journal of Medical Genetics3881\u201385. doi:10.1136\/jmg.38.2.81.","DOI":"10.1136\/jmg.38.2.81"},{"key":"2026070909335023900_bib29","doi-asserted-by":"crossref","unstructured":"Turner\n              NC\n            \n            \n              Reis-Filho\n              JS\n            \n            \n              Russell\n              AM\n            \n            \n              Springall\n              RJ\n            \n            \n              Ryder\n              K\n            \n            \n              Steele\n              D\n            \n            \n              Savage\n              K\n            \n            \n              Gillett\n              CE\n            \n            \n              Schmitt\n              FC\n            \n            \n              Ashworth\n              A\n            \n            \n          \n          2007\n          BRCA1 dysfunction in sporadic basal-like breast cancer. Oncogene262126\u20132132. doi:10.1038\/sj.onc.1210014.","DOI":"10.1038\/sj.onc.1210014"},{"key":"2026070909335023900_bib30","doi-asserted-by":"crossref","unstructured":"Wong\n              EM\n            \n            \n              Southey\n              MC\n            \n            \n              Fox\n              SB\n            \n            \n              Brown\n              MA\n            \n            \n              Dowty\n              JG\n            \n            \n              Jenkins\n              MA\n            \n            \n              Giles\n              GG\n            \n            \n              Hopper\n              JL\n            \n            \n              Dobrovic\n              A\n            \n          \n          2011\n          Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer. Cancer Prevention Research423\u201333. doi:10.1158\/1940-6207.CAPR-10-0212.","DOI":"10.1158\/1940-6207.CAPR-10-0212"}],"container-title":["Endocrine-Related Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/19\/2\/C23.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article-pdf\/19\/2\/C23\/194577\/c23.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article-pdf\/19\/2\/C23\/194577\/c23.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:33:59Z","timestamp":1783604039000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article\/19\/2\/C23\/34838\/Epigenetic-modification-and-cancer-mark-or-stamp"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,1]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4,1]]}},"URL":"https:\/\/doi.org\/10.1530\/erc-12-0003","relation":{},"ISSN":["1479-6821","1351-0088"],"issn-type":[{"value":"1479-6821","type":"electronic"},{"value":"1351-0088","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4,1]]}}}