{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:19:12Z","timestamp":1783606752688,"version":"3.55.0"},"reference-count":21,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Calcitonin (CT) is an important clinical marker for the diagnosis and follow-up of medullary thyroid carcinoma, although it is not absolutely specific. Some authors have reported C-cell hyperplasia in a number of thyroid specimens affected by Hashimoto's thyroiditis. The association between thyroiditis and hypercalcitoninemia is still controversial because some authors have reported low CT levels. The aim of this study is to evaluate the basal CT values in patients with and without thyroid autoimmunity. From May 2005 to February 2010, 1073 patients underwent ultrasonography-guided fine-needle aspiration cytology at the Thyroid Center of Sapienza University of Rome, with evaluation of basal serum FT4, FT3, TSH, and antithyroid peroxidase (anti-TPO) antibodies as well as CT levels. Forty-one patients presented a basal CT level above the reference upper limit. The mean serum CT was significantly lower in women than in men (4.28\u00b16.63 vs 7.50\u00b125.50\u200apg\/ml; P&amp;lt;0.01). Basal serum CT was not significantly higher in patients showing anti-TPO Ab positivity (4.71\u00b16.46 vs 4.84\u00b113.11\u200apg\/ml; P&amp;gt;0.05). Importantly, the rate of \u2018suspicious\u2019 CT values (above the 10\u200apg\/ml cutoff) was not significantly different between patients with or without thyroid autoimmunity (3.9 vs 3.0%). Patients with hypercalcitoninemia suffering from chronic autoimmune thyroiditis should undergo the same clinical evaluation procedure as patients do without thyroid autoimmunity.<\/jats:p>","DOI":"10.1530\/erc-12-0013","type":"journal-article","created":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T21:30:13Z","timestamp":1331155813000},"page":"345-349","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":22,"title":["Interpretation of serum calcitonin in patients with chronic autoimmune thyroiditis"],"prefix":"10.1530","volume":"19","author":[{"given":"Giorgio","family":"Grani","sequence":"first","affiliation":[{"name":"Unit of Endocrinology","department":["Department of Experimental Medicine, \u2018Sapienza\u2019 Universit\u00e0 di Roma, V.le Regina Elena, 324, 00161 Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Nesca","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology","department":["Department of Experimental Medicine, \u2018Sapienza\u2019 Universit\u00e0 di Roma, V.le Regina Elena, 324, 00161 Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Del Sordo","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology","department":["Department of Experimental Medicine, \u2018Sapienza\u2019 Universit\u00e0 di Roma, V.le Regina Elena, 324, 00161 Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Calvanese","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology","department":["Department of Experimental Medicine, \u2018Sapienza\u2019 Universit\u00e0 di Roma, V.le Regina Elena, 324, 00161 Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Carbotta","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology","department":["Department of Experimental Medicine, \u2018Sapienza\u2019 Universit\u00e0 di Roma, V.le Regina Elena, 324, 00161 Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Bianchini","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology","department":["Department of Experimental Medicine, \u2018Sapienza\u2019 Universit\u00e0 di Roma, V.le Regina Elena, 324, 00161 Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Fumarola","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology","department":["Department of Experimental Medicine, \u2018Sapienza\u2019 Universit\u00e0 di Roma, V.le Regina Elena, 324, 00161 Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2026070909362310900_bib1","doi-asserted-by":"crossref","unstructured":"Becker\n              KL\n            \n            \n              Snider\n              R\n            \n            \n              Nylen\n              ES\n            \n          \n          2010\n          Procalcitonin in sepsis and systemic inflammation: a harmful biomarker and a therapeutic target. British Journal of Pharmacology159253\u2013264. doi:10.1111\/j.1476-5381.2009.00433.x.","DOI":"10.1111\/j.1476-5381.2009.00433.x"},{"key":"2026070909362310900_bib2","doi-asserted-by":"crossref","unstructured":"Body\n              JJ\n            \n            \n              Demeester-Mirkine\n              N\n            \n            \n              Borkowski\n              A\n            \n            \n              Suciu\n              S\n            \n            \n              Corvilain\n              J\n            \n          \n          1986\n          Calcitonin deficiency in primary hypothyroidism. Journal of Clinical Endocrinology and Metabolism62700\u2013703. doi:10.1210\/jcem-62-4-700.","DOI":"10.1210\/jcem-62-4-700"},{"key":"2026070909362310900_bib3","doi-asserted-by":"crossref","unstructured":"Borges\n              MF\n            \n            \n              Abelin\n              NM\n            \n            \n              Menezes\n              FO\n            \n            \n              Dahia\n              PL\n            \n            \n              Toledo\n              SPA\n            \n          \n          1998\n          Calcitonin deficiency in early stages of chronic autoimmune thyroiditis. Clinical Endocrinology4969\u201375. doi:10.1046\/j.1365-2265.1998.00478.x.","DOI":"10.1046\/j.1365-2265.1998.00478.x"},{"key":"2026070909362310900_bib4","doi-asserted-by":"crossref","unstructured":"Cheung\n              K\n            \n            \n              Roman\n              SA\n            \n            \n              Wang\n              TS\n            \n            \n              Walker\n              HD\n            \n            \n              Sosa\n              JA\n            \n          \n          2008\n          Calcitonin measurement in the evaluation of thyroid nodules in the United States: a cost-effectiveness and decision analysis. Journal of Clinical Endocrinology and Metabolism932173\u20132180. doi:10.1210\/jc.2007-2496.","DOI":"10.1210\/jc.2007-2496"},{"key":"2026070909362310900_bib5","doi-asserted-by":"crossref","unstructured":"Costante\n              G\n            \n            \n              Meringolo\n              D\n            \n            \n              Durante\n              C\n            \n            \n              Bianchi\n              D\n            \n            \n              Nocera\n              M\n            \n            \n              Tumino\n              S\n            \n            \n              Crocetti\n              U\n            \n            \n              Attard\n              M\n            \n            \n              Maranghi\n              M\n            \n            \n              Torlontano\n              M\n            \n            \n          \n          2007\n          Predictive value of serum calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules. Journal of Clinical Endocrinology and Metabolism92450\u2013455. doi:10.1210\/jc.2006-1590.","DOI":"10.1210\/jc.2006-1590"},{"key":"2026070909362310900_bib6","doi-asserted-by":"crossref","unstructured":"D'Herbomez\n              M\n            \n            \n              Caron\n              P\n            \n            \n              Bauters\n              C\n            \n            \n              Do Cao\n              C\n            \n            \n              Schlienger\n              JL\n            \n            \n              Sapin\n              R\n            \n            \n              Baldet\n              L\n            \n            \n              Carnaille\n              B\n            \n            \n              Wemeau\n              JL\n            \n          \n          2007\n          Reference range of serum calcitonin levels in humans: influence of calcitonin assays, sex, age, and cigarette smoking. European Journal of Endocrinology157749\u2013755. doi:10.1530\/EJE-07-0566.","DOI":"10.1530\/EJE-07-0566"},{"key":"2026070909362310900_bib7","doi-asserted-by":"crossref","unstructured":"Elisei\n              R\n            \n          \n          2008\n          Routine serum calcitonin measurement in the evaluation of thyroid nodules. Best Practice & Research. Clinical Endocrinology & Metabolism22941\u2013953. doi:10.1016\/j.beem.2008.09.008.","DOI":"10.1016\/j.beem.2008.09.008"},{"key":"2026070909362310900_bib8","doi-asserted-by":"crossref","unstructured":"Elisei\n              R\n            \n            \n              Bottici\n              V\n            \n            \n              Luchetti\n              F\n            \n            \n              Di Coscio\n              G\n            \n            \n              Romei\n              C\n            \n            \n              Grasso\n              L\n            \n            \n              Miccoli\n              P\n            \n            \n              Iacconi\n              P\n            \n            \n              Basolo\n              F\n            \n            \n              Pinchera\n              A\n            \n            \n          \n          2004\n          Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medullary thyroid cancer: experience in 10,864 patients with nodular thyroid disorders. Journal of Clinical Endocrinology and Metabolism89163\u2013168. doi:10.1210\/jc.2003-030550.","DOI":"10.1210\/jc.2003-030550"},{"key":"2026070909362310900_bib9","unstructured":"Fadda\n              G\n            \n            \n              Basolo\n              F\n            \n            \n              Bondi\n              A\n            \n            \n              Bussolati\n              G\n            \n            \n              Crescenzi\n              A\n            \n            \n              Nappi\n              O\n            \n            \n              Nardi\n              F\n            \n            \n              Papotti\n              M\n            \n            \n              Taddei\n              G\n            \n            \n              Palombini\n              L\n            \n          \n          2010\n          Cytological classification of thyroid nodules. Proposal of the SIAPEC-IAP Italian Consensus Working Group. Pathologica102405\u2013408."},{"key":"2026070909362310900_bib10","doi-asserted-by":"crossref","unstructured":"Giovanella\n              L\n            \n            \n              Suriano\n              S\n            \n          \n          2011\n          Spurious hypercalcitoninemia and heterophilic antibodies in patients with thyroid nodules. Head & Neck3395\u201397. doi:10.1002\/hed.21405.","DOI":"10.1002\/hed.21405"},{"key":"2026070909362310900_bib11","doi-asserted-by":"crossref","unstructured":"Guyetant\n              S\n            \n            \n              Wion-Barbot\n              N\n            \n            \n              Rousselet\n              MC\n            \n            \n              Franc\n              B\n            \n            \n              Bigorgne\n              JC\n            \n            \n              Saint-Andre\n              JP\n            \n          \n          1994\n          C-cell hyperplasia associated with chronic lymphocytic thyroiditis: a retrospective quantitative study of 112 cases. Human Pathology25514\u2013521. doi:10.1016\/0046-8177(94)90124-4.","DOI":"10.1016\/0046-8177(94)90124-4"},{"key":"2026070909362310900_bib12","doi-asserted-by":"crossref","unstructured":"Karanikas\n              G\n            \n            \n              Moameni\n              A\n            \n            \n              Poetzi\n              C\n            \n            \n              Zettinig\n              G\n            \n            \n              Kaserer\n              K\n            \n            \n              Bieglmayer\n              C\n            \n            \n              Niederle\n              B\n            \n            \n              Dudczak\n              R\n            \n            \n              Pirich\n              C\n            \n          \n          2004\n          Frequency and relevance of elevated calcitonin levels in patients with neoplastic and nonneoplastic thyroid disease and in healthy subjects. Journal of Clinical Endocrinology and Metabolism89515\u2013519. doi:10.1210\/jc.2003-030709.","DOI":"10.1210\/jc.2003-030709"},{"key":"2026070909362310900_bib13","doi-asserted-by":"crossref","unstructured":"Kloos\n              RT\n            \n            \n              Eng\n              C\n            \n            \n              Evans\n              DB\n            \n            \n              Francis\n              GL\n            \n            \n              Gagel\n              RF\n            \n            \n              Gharib\n              H\n            \n            \n              Moley\n              JF\n            \n            \n              Pacini\n              F\n            \n            \n              Ringel\n              MD\n            \n            \n              Schlumberger\n              M\n            \n            \n          \n          2009\n          Medullary thyroid cancer: management guidelines of the American Thyroid Association. Thyroid19565\u2013612. doi:10.1089\/thy.2008.0403.","DOI":"10.1089\/thy.2008.0403"},{"key":"2026070909362310900_bib14","doi-asserted-by":"crossref","unstructured":"Lima\n              MA\n            \n            \n              Santos\n              BM\n            \n            \n              Borges\n              MF\n            \n          \n          1998\n          Quantitative analysis of C cells in Hashimoto's thyroiditis. Thyroid8505\u2013509. doi:10.1089\/thy.1998.8.505.","DOI":"10.1089\/thy.1998.8.505"},{"key":"2026070909362310900_bib15","unstructured":"Niccoli\n              P\n            \n            \n              Conte-Devolx\n              B\n            \n            \n              Lejeune\n              PJ\n            \n            \n              Carayon\n              P\n            \n            \n              Henry\n              JF\n            \n            \n              Roux\n              F\n            \n            \n              Wion-Barbot\n              N\n            \n            \n              Bigorgne\n              JC\n            \n          \n          1996\n          Hypercalcitoninemia in conditions other than medullary cancers of the thyroid. Annales d'endocrinologie5715\u201321."},{"key":"2026070909362310900_bib16","doi-asserted-by":"crossref","unstructured":"Papi\n              G\n            \n            \n              Corsello\n              SM\n            \n            \n              Cioni\n              K\n            \n            \n              Pizzini\n              AM\n            \n            \n              Corrado\n              S\n            \n            \n              Carapezzi\n              C\n            \n            \n              Fadda\n              G\n            \n            \n              Baldini\n              A\n            \n            \n              Carani\n              C\n            \n            \n              Pontecorvi\n              A\n            \n            \n          \n          2006\n          Value of routine measurement of serum calcitonin concentrations in patients with nodular thyroid disease: a multicenter study. Journal of Endocrinological Investigation29427\u2013437.","DOI":"10.1007\/BF03344126"},{"key":"2026070909362310900_bib17","doi-asserted-by":"crossref","unstructured":"Poppe\n              K\n            \n            \n              Verbruggen\n              LA\n            \n            \n              Velkeniers\n              B\n            \n            \n              Finn\u00e9\n              E\n            \n            \n              Body\n              JJ\n            \n            \n              Vanhaelst\n              L\n            \n          \n          1999\n          Calcitonin reserve in different stages of atrophic autoimmune thyroiditis. Thyroid91211\u20131214. doi:10.1089\/thy.1999.9.1211.","DOI":"10.1089\/thy.1999.9.1211"},{"key":"2026070909362310900_bib18","doi-asserted-by":"crossref","unstructured":"Scheuba\n              C\n            \n            \n              Kaserer\n              K\n            \n            \n              Moritz\n              A\n            \n            \n              Drosten\n              R\n            \n            \n              Vierhapper\n              H\n            \n            \n              Bieglmayer\n              C\n            \n            \n              Haas\n              OA\n            \n            \n              Niederle\n              B\n            \n          \n          2009\n          Sporadic hypercalcitoninemia: clinical and therapeutic consequences. Endocrine-Related Cancer16243\u2013253. doi:10.1677\/ERC-08-0059.","DOI":"10.1677\/ERC-08-0059"},{"key":"2026070909362310900_bib19","unstructured":"Schuetz\n              M\n            \n            \n              Beheshti\n              M\n            \n            \n              Oezer\n              S\n            \n            \n              Novotny\n              C\n            \n            \n              Paul\n              M\n            \n            \n              Hofmann\n              A\n            \n            \n              Bieglmayer\n              C\n            \n            \n              Niederle\n              B\n            \n            \n              Kletter\n              K\n            \n            \n              Dudczak\n              R\n            \n            \n          \n          2006\n          Calcitonin measurements for early detection of medullary thyroid carcinoma or its premalignant conditions in Hashimoto's thyroiditis. Anticancer Research26723\u2013727."},{"key":"2026070909362310900_bib20","doi-asserted-by":"crossref","unstructured":"Tabassian\n              AR\n            \n            \n              Nylen\n              ES\n            \n            \n              Linnoila\n              RI\n            \n            \n              Snider\n              RH\n            \n            \n              Cassidy\n              MM\n            \n            \n              Becker\n              KL\n            \n          \n          1989\n          Stimulation of hamster pulmonary neuroendocrine cells and associated peptides by repeated exposure to cigarette smoke. American Review of Respiratory Disease140436\u2013440. doi:10.1164\/ajrccm\/140.2.436.","DOI":"10.1164\/ajrccm\/140.2.436"},{"key":"2026070909362310900_bib21","doi-asserted-by":"crossref","unstructured":"Toledo\n              SP\n            \n            \n              Louren\u00e7o\n              DM\n              Jr\n            \n            \n              Santos\n              MA\n            \n            \n              Tavares\n              MR\n            \n            \n              Toledo\n              RA\n            \n            \n              Correia-Deur\n              JE\n            \n          \n          2009\n          Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma. Clinics64699\u2013706. doi:10.1590\/S1807-59322009000700015.","DOI":"10.1590\/S1807-59322009000700015"}],"container-title":["Endocrine-Related Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/19\/3\/345.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article-pdf\/19\/3\/345\/194964\/345.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article-pdf\/19\/3\/345\/194964\/345.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:36:30Z","timestamp":1783604190000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article\/19\/3\/345\/34896\/Interpretation-of-serum-calcitonin-in-patients"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,1]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6,1]]}},"URL":"https:\/\/doi.org\/10.1530\/erc-12-0013","relation":{},"ISSN":["1479-6821","1351-0088"],"issn-type":[{"value":"1479-6821","type":"electronic"},{"value":"1351-0088","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6,1]]}}}