{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:18:53Z","timestamp":1784557133187,"version":"3.55.0"},"reference-count":33,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>\n                    B7H1 is consistently associated with inhibition of the immune system in many solid tumors. However, there is no report about its impact on differentiated thyroid carcinoma (DTC) presentation, aggressiveness, or evolution. Aiming to investigate the role of B7H1 in DTC and correlate this protein with other tumor-infiltrating immune cells, we studied 407 thyroid nodule tissue samples including 293 from DTC patients, all managed according to a same standard protocol. In addition, we obtained 5 normal and 114 benign thyroid lesions. Eighteen out of the 253 papillary thyroid carcinomas were paired with respective metastatic lymph node tissues. B7H1 (CD274) protein expression was assessed by immunohistochemistry and the gene expression was quantified by real-time PCR. Malignant tissues displayed a more intense B7H1 staining and higher mRNA levels than benign tissues (both\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.0001). We observed a positive linear correlation between higher age at diagnosis and\n                    <jats:italic>B7H1<\/jats:italic>\n                    mRNA levels (\n                    <jats:italic>P<\/jats:italic>\n                    =0.02896). Elevated levels of B7H1 protein were associated with the presence of CD4+, CD8+, CD20+, and FoxP3+ lymphocytes (all\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05); tumor-associated macrophages (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.0001); and the presence of myeloid-derived suppressor cells (\n                    <jats:italic>P<\/jats:italic>\n                    =0.03256). Stage II\u2013IV patients presented higher\n                    <jats:italic>B7H1<\/jats:italic>\n                    mRNA levels than stage I cases (\n                    <jats:italic>P<\/jats:italic>\n                    =0.03522). On the contrary, a decreased expression of B7H1 protein was observed in lymph node metastasis (\n                    <jats:italic>P<\/jats:italic>\n                    =0.0152). In conclusion, our data demonstrate that B7H1 expression is associated with features of aggressiveness, suggesting that this is an immune evasion mechanism of DTC cells.\n                  <\/jats:p>","DOI":"10.1530\/erc-12-0313","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T20:13:51Z","timestamp":1354220031000},"page":"103-110","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":68,"title":["Differentiated thyroid carcinomas may elude the immune system by B7H1 upregulation"],"prefix":"10.1530","volume":"20","author":[{"given":"Lucas Leite","family":"Cunha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjory Alana","family":"Marcello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine Cristina","family":"Morari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suely","family":"Nonogaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Frangiotti","family":"Conte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Gerhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Augusto","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Vassallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Sterian","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"issue":"11","key":"1_35881622","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1089\/thy.2009.0110","volume":"19","author":"Cooper","year":"2009","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"2","key":"2_22299342","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1002\/ijc.21775","volume":"119","author":"Blank","year":"2006","journal-title":"International journal of cancer. Journal international du cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0020-7136","issn-type":"print"},{"issue":"4","key":"3_38833907","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1158\/0008-5472.CAN-10-2217","volume":"71","year":"2011","journal-title":"Cancer Research","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"issue":"14","key":"4_40249618","doi-asserted-by":"publisher","first-page":"4737","DOI":"10.1158\/0008-5472.CAN-11-0527","volume":"71","year":"2011","journal-title":"Cancer Research","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"5_45219842","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00262-011-1094-3","volume":"61","year":"2012","journal-title":"CANCER IMMUNOLOGY AND IMMUNOTHERAPY"},{"issue":"2","key":"6_40788936","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s00405-011-1764-y","volume":"269","author":"Cunha","year":"2012","journal-title":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0937-4477","issn-type":"print"},{"key":"7_45219843","first-page":"1203","volume":"66","year":"2011","ISSN":"https:\/\/id.crossref.org\/issn\/0097-3521","issn-type":"print"},{"issue":"3","key":"8_42278448","doi-asserted-by":"publisher","first-page":"L31","DOI":"10.1530\/ERC-11-0285","volume":"19","year":"2012","journal-title":"Endocrine-Related Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1351-0088","issn-type":"print"},{"key":"9_45219844","first-page":"483","volume":"67","year":"2012","ISSN":"https:\/\/id.crossref.org\/issn\/0097-3521","issn-type":"print"},{"issue":"12","key":"10_6385133","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1038\/70932","volume":"5","author":"Dong","year":"1999","journal-title":"Nature medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1078-8956","issn-type":"print"},{"issue":"8","key":"11_17175121","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nm730","volume":"8","author":"Dong","year":"2002","journal-title":"Nature medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1078-8956","issn-type":"print"},{"issue":"5","key":"12_36732405","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1210\/jc.2009-2564","volume":"95","year":"2010","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"6","key":"13_42295059","doi-asserted-by":"publisher","first-page":"E934","DOI":"10.1210\/jc.2011-3428","volume":"97","year":"2012","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"14_42228343","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1002\/cncr.25747","volume":"117","year":"2011","ISSN":"https:\/\/id.crossref.org\/issn\/1097-0142","issn-type":"print"},{"issue":"5","key":"15_42020893","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1210\/jc.2011-1838","volume":"97","year":"2012","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"5","key":"16_39415722","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"key":"17_38383507","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1002\/cncr.24899","volume":"116","year":"2010","ISSN":"https:\/\/id.crossref.org\/issn\/1097-0142","issn-type":"print"},{"issue":"17","key":"18_29336034","doi-asserted-by":"publisher","first-page":"8344","DOI":"10.1158\/0008-5472.CAN-06-3304","volume":"67","author":"Hinz","year":"2007","journal-title":"Cancer Research","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"19_45219845","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3748\/wjg.v18.i9.971","volume":"18","year":"2012","journal-title":"WORLD JOURNAL OF GASTROENTEROLOGY"},{"issue":"3","key":"20_41388772","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1002\/eji.201141931","volume":"42","author":"Kaiser","year":"2012","journal-title":"European journal of immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2980","issn-type":"print"},{"issue":"5","key":"21_16528396","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1089\/thy.1996.6.445","volume":"6","author":"Kasagi","year":"1996","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"10","key":"22_32420311","doi-asserted-by":"crossref","first-page":"6738","DOI":"10.4049\/jimmunol.181.10.6738","volume":"181","author":"Kinter","year":"2008","journal-title":"The Journal of Immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"issue":"11","key":"23_34179941","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1200\/JCO.2008.17.9036","volume":"27","year":"2009","journal-title":"Journal of Clinical Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0732-183X","issn-type":"print"},{"issue":"1","key":"24_35057398","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1309\/AJCPJV0SKAF2PCMY","volume":"132","author":"Minot","year":"2009","journal-title":"American Journal of Clinical Pathology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9173","issn-type":"print"},{"issue":"4","key":"25_38532564","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1007\/s12022-010-9137-4","volume":"21","author":"Morari","year":"2010","journal-title":"Endocrine pathology","ISSN":"https:\/\/id.crossref.org\/issn\/1046-3976","issn-type":"print"},{"issue":"2","key":"26_39811425","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/j.1365-2265.2011.04032.x","volume":"75","author":"Morari","year":"2011","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"5","key":"27_30902274","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.1016\/j.juro.2008.01.056","volume":"179","author":"Routh","year":"2008","journal-title":"The Journal of urology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-5347","issn-type":"print"},{"issue":"5","key":"28_28534947","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1007\/s00268-006-0864-0","volume":"31","author":"Shaha","year":"2007","journal-title":"World journal of surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0364-2313","issn-type":"print"},{"key":"29_45219846","first-page":"127ra137","volume":"4","year":"2012","journal-title":"Science Translational Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1946-6234","issn-type":"print"},{"issue":"6","key":"30_23717355","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1093\/ndt\/gfl818","volume":"22","year":"2007","journal-title":"Nephrology Dialysis Transplantation","ISSN":"https:\/\/id.crossref.org\/issn\/0931-0509","issn-type":"print"},{"issue":"5","key":"31_36612731","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1007\/s00268-010-0448-x","volume":"34","author":"Wang","year":"2010","journal-title":"World journal of surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0364-2313","issn-type":"print"},{"issue":"2","key":"32_39108068","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/eji.201040979","volume":"41","author":"Wolfle","year":"2011","journal-title":"European journal of immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2980","issn-type":"print"},{"issue":"6","key":"33_36447819","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1215\/15228517-2009-014","volume":"11","year":"2009","journal-title":"Neuro-Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/1522-8517","issn-type":"print"}],"container-title":["Endocrine-Related Cancer"],"original-title":[],"link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/20\/1\/103.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/erc.bioscientifica.com\/downloadpdf\/journals\/erc\/20\/1\/103.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:51:26Z","timestamp":1784555486000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/erc\/article\/20\/1\/103-110\/34946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,28]]},"references-count":33,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/erc-12-0313","relation":{},"ISSN":["1351-0088","1479-6821"],"issn-type":[{"value":"1351-0088","type":"print"},{"value":"1479-6821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,28]]}}}