{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:18:32Z","timestamp":1784557112833,"version":"3.55.0"},"reference-count":38,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>\n                    Utilizing\n                    <jats:italic>BRAF<\/jats:italic>\n                    <jats:sup>V600E<\/jats:sup>\n                    mutation as a marker may reduce unnecessary prophylactic central neck dissection (pCND) in clinically nodal negative (cN0) neck for small (\u22642\u200acm) classical papillary thyroid carcinoma (PTC). We aimed to assess whether\n                    <jats:italic>BRAF<\/jats:italic>\n                    is a significant independent predictor of occult central nodal metastasis (CNM) and its contribution to the overall prediction after adjusting for other significant preoperative clinical factors in small PTC. Primary tumor tissue (paraffin-embedded) from 845 patients with small classical cN0 PTC who underwent pCND was tested for\n                    <jats:italic>BRAF<\/jats:italic>\n                    mutation. Clinicopathologic factors were compared between those with and without\n                    <jats:italic>BRAF<\/jats:italic>\n                    .\n                    <jats:italic>BRAF<\/jats:italic>\n                    was evaluated to see if it was an independent factor for CNM. Prediction scores were generated using logistic regression models and their predictability was measured by the area under the ROC curve (AUC). The prevalence of\n                    <jats:italic>BRAF<\/jats:italic>\n                    was 628\/845 (74.3%) while the rate of CNM was 285\/845 (33.7%). Male sex (odds ratio (OR): 2.68, 95% CI: 1.71\u20134.20), large tumor size (OR: 2.68, 95% CI: 1.80\u20134.00), multifocality (OR: 1.49, 95% CI: 1.07\u20132.09), lymphovascular permeation (OR: 10.40, 95% CI: 5.18\u201320.88), and\n                    <jats:italic>BRAF<\/jats:italic>\n                    (OR: 1.65, 95% CI: 1.10\u20132.46) were significant independent predictors of CNM, while coexisting Hashimoto's thyroiditis (OR: 0.56, 95% CI: 0.40\u20130.80) was an independent protective factor. The AUC for prediction score based on tumor size and male sex was similar to that of prediction score based on tumor size, male sex, and\n                    <jats:italic>BRAF<\/jats:italic>\n                    status (0.68 vs 0.69,\n                    <jats:italic>P<\/jats:italic>\n                    =0.60). Although\n                    <jats:italic>BRAF<\/jats:italic>\n                    was an independent predictor of CNM, knowing its status did not substantially improve the overall prediction. A simpler prediction score based on male sex and tumor size might be sufficient.\n                  <\/jats:p>","DOI":"10.1530\/erc-13-0291","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T00:54:46Z","timestamp":1389228886000},"page":"285-295","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":43,"title":["Is BRAFV600E mutation a marker for central nodal metastasis in small papillary thyroid carcinoma?"],"prefix":"10.1530","volume":"21","author":[{"given":"Brian Hung-Hin","family":"Lang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Jun","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J","family":"Cowling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Sook","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeo-Kyu","family":"Youn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"issue":"1","key":"1_44115496","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1530\/ERC-12-0309","volume":"20","year":"2013","journal-title":"Endocrine-Related Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1351-0088","issn-type":"print"},{"issue":"11","key":"2_35881623","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1089\/thy.2009.0159","volume":"19","author":"Carty","year":"2009","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"5","key":"3_22876532","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1111\/j.1365-2265.2006.02646.x","volume":"65","author":"Chung","year":"2006","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"12","key":"4_30035443","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1007\/s00268-007-9117-0","volume":"31","author":"Chung","year":"2007","journal-title":"World journal of surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0364-2313","issn-type":"print"},{"issue":"11","key":"5_35881622","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1089\/thy.2009.0110","volume":"19","author":"Cooper","year":"2009","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"key":"6_47496729","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1089\/thy.2012.0304","volume":"23","year":"2013","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"6","key":"7_45677500","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1210\/jc.2013-1309","volume":"98","year":"2013","journal-title":"Journal of Clinical Endocrinology &amp; 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