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The importance of the role of hormones for both normal mammary gland and breast cancer development is well established, but it was not until recently that the effects of hormones on BCSCs have been investigated. This review will discuss recent studies highlighting how ovarian steroid hormones estrogen and progesterone, as well as therapies against them, can regulate BCSC activity.<\/jats:p>","DOI":"10.1530\/erc-15-0350","type":"journal-article","created":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T20:24:01Z","timestamp":1442521441000},"page":"T177-T186","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":30,"title":["The role of steroid hormones in breast cancer stem cells"],"prefix":"10.1530","volume":"22","author":[{"given":"Bruno M","family":"Sim\u00f5es","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis G","family":"Alferez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sacha J","family":"Howell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2015110216263174000_22.6.T177.1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0530291100"},{"key":"2015110216263174000_22.6.T177.2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc721"},{"key":"2015110216263174000_22.6.T177.3","doi-asserted-by":"publisher","DOI":"10.1038\/nature09027"},{"key":"2015110216263174000_22.6.T177.4","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-012-0127-5"},{"key":"2015110216263174000_22.6.T177.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109653"},{"key":"2015110216263174000_22.6.T177.6","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.121"},{"key":"2015110216263174000_22.6.T177.7","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026339111278"},{"key":"2015110216263174000_22.6.T177.8","doi-asserted-by":"publisher","DOI":"10.1186\/bcr559"},{"key":"2015110216263174000_22.6.T177.9","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3518"},{"key":"2015110216263174000_22.6.T177.10","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23103"},{"key":"2015110216263174000_22.6.T177.11","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1630"},{"key":"2015110216263174000_22.6.T177.12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1500"},{"key":"2015110216263174000_22.6.T177.13","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.275"},{"key":"2015110216263174000_22.6.T177.14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101253440407"},{"key":"2015110216263174000_22.6.T177.15","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.11.814"},{"key":"2015110216263174000_22.6.T177.16","doi-asserted-by":"publisher","DOI":"10.1007\/s10911-010-9173-1"},{"key":"2015110216263174000_22.6.T177.17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088034"},{"key":"2015110216263174000_22.6.T177.18","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1061803"},{"key":"2015110216263174000_22.6.T177.19","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr393"},{"key":"2015110216263174000_22.6.T177.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60993-8"},{"key":"2015110216263174000_22.6.T177.21","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1204"},{"key":"2015110216263174000_22.6.T177.22","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk133"},{"key":"2015110216263174000_22.6.T177.23","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2349"},{"key":"2015110216263174000_22.6.T177.24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1007863107"},{"key":"2015110216263174000_22.6.T177.25","doi-asserted-by":"crossref","unstructured":"Finlay-Schultz J Cittelly DM Hendricks P Patel P Kabos P Jacobsen BM Richer JK Sartorius CA 2014 Progesterone downregulation of miR-141 contributes to expansion of stem-like breast cancer cells through maintenance of progesterone receptor and Stat5a. 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