{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:14:30Z","timestamp":1788383670430,"version":"build-2803163510"},"reference-count":41,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It has been reported that papillary thyroid carcinoma (PTC) with chronic lymphocytic thyroiditis (CLT) is less associated with extrathyroidal extension (ETE), advanced tumor stage and lymph node (LN) metastasis. Other studies have suggested that concurrent CLT could antagonize PTC progression, even in BRAF-positive patients. Since the clinical significance of the BRAF mutation has been particularly associated with conventional PTC, the purpose of this study was to determine the clinical significance of CLT according to BRAF mutation status in conventional PTC patients. We retrospectively reviewed the medical records of 3332 conventional PTC patients who underwent total thyroidectomy with bilateral central neck dissection at the Thyroid Cancer Center of Samsung Medical Center between January 2008 and June 2015. In this study, the prevalence of BRAF mutation was significantly less frequent in conventional PTC patients with CLT (76.9% vs 86.6%). CLT was an independent predictor for low prevalence of ETE in both BRAF-negative (OR=0.662, P=0.023) and BRAF-positive (OR=0.817, P=0.027) conventional PTC patients. In addition, CLT was an independent predictor for low prevalence of CLNM in both BRAF-negative (OR=0.675, P=0.044) and BRAF-positive (OR=0.817, P=0.030) conventional PTC patients. In conclusion, BRAF mutation was significantly less frequent in conventional PTC patients with CLT. However, CLT was an independent predictor for less aggressiveness in conventional PTC patients regardless of BRAF mutation status.<\/jats:p>","DOI":"10.1530\/erc-15-0408","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T21:39:16Z","timestamp":1448314756000},"page":"27-34","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":40,"title":["Chronic lymphocytic thyroiditis and BRAF V600E in papillary thyroid carcinoma"],"prefix":"10.1530","volume":"23","author":[{"given":"Seo Ki","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Breast and Endocrine Surgery 1","department":["Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Woo","family":"Woo","sequence":"additional","affiliation":[{"name":"Division of Breast and Endocrine Surgery 1","department":["Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Breast and Endocrine Surgery 2","department":["Department of Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inhye","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Breast and Endocrine Surgery 1","department":["Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ho","family":"Choe","sequence":"additional","affiliation":[{"name":"Division of Breast and Endocrine Surgery 1","department":["Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Breast and Endocrine Surgery 1","department":["Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Breast and Endocrine Surgery 1","department":["Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2026070906082251600_bib1","unstructured":"Ahn\n              HY\n            \n            \n              Park\n              YJ\n            \n          \n          2009\n          Incidence and clinical characteristics of thyroid cancer in Korea. 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