{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:56:27Z","timestamp":1790816187010,"version":"4.1.0"},"reference-count":94,"publisher":"Bioscientifica","issue":"10","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>\n                    Hypertension is a common medical condition and affects approximately 20% of the population in developed countries. Primary aldosteronism is the most common form of secondary hypertension and affects 8\u201313% of patients with hypertension. The two most common causes of primary aldosteronism are aldosterone-producing adenoma and bilateral adrenal hyperplasia. Familial hyperaldosteronism types I, II and III are the known genetic syndromes, in which both adrenal glands produce excessive amounts of aldosterone. However, only a minority of patients with primary aldosteronism have one of these syndromes. Several novel susceptibility genes have been found to be mutated in aldosterone-producing adenomas:\n                    <jats:italic>KCNJ5<\/jats:italic>\n                    ,\n                    <jats:italic>ATP1A1<\/jats:italic>\n                    ,\n                    <jats:italic>ATP2B3<\/jats:italic>\n                    ,\n                    <jats:italic>CTNNB1, CACNA1D, CACNA1H<\/jats:italic>\n                    and\n                    <jats:italic>ARMC5<\/jats:italic>\n                    . This review describes the genes currently known to be responsible for primary aldosteronism, discusses the origin of aldosterone-producing adenomas and considers the future clinical implications based on these novel insights.\n                  <\/jats:p>","DOI":"10.1530\/erc-16-0055","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T21:58:21Z","timestamp":1470175101000},"page":"R437-R454","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":32,"title":["Genetics of primary hyperaldosteronism"],"prefix":"10.1530","volume":"23","author":[{"given":"Ravi 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