{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:18:45Z","timestamp":1784557125538,"version":"3.55.0"},"reference-count":38,"publisher":"Bioscientifica","issue":"5","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>\n                    Breast cancer is rare in male patients. Certain predisposing factors, be they genetic (e.g.,\n                    <jats:italic>BRCA2<\/jats:italic>\n                    gene mutations) or hormonal (imbalance between estrogen and androgen levels), have been implicated in male breast cancer pathophysiology. Male-to-female (MtF) transsexualism is a condition that generally involves cross-sex hormone therapy. Anti-androgens and estrogens are used to mimic the female hormonal environment and induce the cross-sex secondary characteristics. In certain situations, the change in the hormonal milieu can be disadvantageous and favor the development of hormone-dependent pathologies, such as cancer. We report a case of a MtF transgender patient who developed breast cancer after 7 years of cross-sex hormonal therapy. The patient was found to be\n                    <jats:italic>BRCA2<\/jats:italic>\n                    positive, and suffered recurrent disease. The patient was unaware of being a member of an established\n                    <jats:italic>BRCA2<\/jats:italic>\n                    mutation-positive kindred. This represents the first case of a\n                    <jats:italic>BRCA2<\/jats:italic>\n                    mutation predisposing to breast cancer in a MtF transgender patient.\n                  <\/jats:p>","DOI":"10.1530\/erc-16-0057","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T20:57:26Z","timestamp":1458593846000},"page":"391-397","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":31,"title":["Breast cancer in a male-to-female transsexual patient with a BRCA2 mutation"],"prefix":"10.1530","volume":"23","author":[{"given":"Vinciane","family":"Corman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iulia","family":"Potorac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Manto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Dassy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Segers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Thiry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Bours","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian F","family":"Daly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Beckers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2016060718483194000_23.5.391.1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3202"},{"key":"2016060718483194000_23.5.391.2","unstructured":"American Cancer Society 2015 Cancer Facts & Figures 2015. 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