{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:18:45Z","timestamp":1784557125498,"version":"3.55.0"},"reference-count":142,"publisher":"Bioscientifica","issue":"6","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Familial syndromes of hyperparathyroidism, including multiple endocrine neoplasia type 1 (MEN1), multiple endocrine neoplasia type 2A (MEN2A), and the hyperparathyroidism-jaw tumor (HPT-JT), comprise 2\u20135% of primary hyperparathyroidism cases. Familial syndromes of hyperparathyroidism are also associated with a range of endocrine and nonendocrine tumors, including potential malignancies. Complications of the associated neoplasms are the major causes of morbidities and mortalities in these familial syndromes, e.g., parathyroid carcinoma in HPT-JT syndrome; thymic, bronchial, and enteropancreatic neuroendocrine tumors in MEN1; and medullary thyroid cancer and pheochromocytoma in MEN2A. Because of the different underlying mechanisms of neoplasia, these familial tumors may have different characteristics compared with their sporadic counterparts. Large-scale clinical trials are frequently lacking due to the rarity of these diseases. With technological advances and the development of new medications, the natural history, diagnosis, and management of these syndromes are also evolving. In this article, we summarize the recent knowledge on endocrine neoplasms in three familial hyperparathyroidism syndromes, with an emphasis on disease characteristics, molecular pathogenesis, recent developments in biochemical and radiological evaluation, and expert opinions on surgical and medical therapies. Because these familial hyperparathyroidism syndromes are associated with a wide variety of tumors in different organs, this review is focused on those endocrine neoplasms with malignant potential.<\/jats:p>","DOI":"10.1530\/erc-16-0059","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T12:59:52Z","timestamp":1464008392000},"page":"R229-R247","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":31,"title":["Endocrine neoplasms in familial syndromes of hyperparathyroidism"],"prefix":"10.1530","volume":"23","author":[{"given":"Yulong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F","family":"Simonds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2016062119392443000_23.6.R229.1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e318187efef"},{"key":"2016062119392443000_23.6.R229.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.endonu.2011.06.006"},{"key":"2016062119392443000_23.6.R229.3","first-page":"855","article-title":"[Case of thymic carcinoid associated with multiple endocrine neoplasia type I treated effectively with chemotherapy]","volume":"48","author":"Amano","year":"2010","journal-title":"Nihon Kokyuki Gakkai Zasshi"},{"key":"2016062119392443000_23.6.R229.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02480.x"},{"key":"2016062119392443000_23.6.R229.5","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4672-3"},{"key":"2016062119392443000_23.6.R229.6","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.141.12.1199"},{"key":"2016062119392443000_23.6.R229.7","doi-asserted-by":"publisher","DOI":"10.1159\/000357779"},{"key":"2016062119392443000_23.6.R229.8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031911"},{"key":"2016062119392443000_23.6.R229.9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01535.x"},{"key":"2016062119392443000_23.6.R229.10","doi-asserted-by":"publisher","DOI":"10.5694\/mja12.11243"},{"key":"2016062119392443000_23.6.R229.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02460.x"},{"key":"2016062119392443000_23.6.R229.12","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209893"},{"key":"2016062119392443000_23.6.R229.13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2789"},{"key":"2016062119392443000_23.6.R229.14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01348.x"},{"key":"2016062119392443000_23.6.R229.15","doi-asserted-by":"publisher","DOI":"10.1038\/ng1048"},{"key":"2016062119392443000_23.6.R229.16","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70154-8"},{"key":"2016062119392443000_23.6.R229.17","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0549"},{"key":"2016062119392443000_23.6.R229.18","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5311.404"},{"key":"2016062119392443000_23.6.R229.19","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-014-0187-3"},{"key":"2016062119392443000_23.6.R229.20","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1800"},{"key":"2016062119392443000_23.6.R229.21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1560"},{"key":"2016062119392443000_23.6.R229.22","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00572"},{"key":"2016062119392443000_23.6.R229.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2015.03.016"},{"key":"2016062119392443000_23.6.R229.24","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.48.4659"},{"key":"2016062119392443000_23.6.R229.25","doi-asserted-by":"publisher","DOI":"10.1038\/nature03445"},{"key":"2016062119392443000_23.6.R229.26","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-22542-5_6"},{"key":"2016062119392443000_23.6.R229.27","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-009-0740-z"},{"key":"2016062119392443000_23.6.R229.28","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-1-199607010-00005"},{"key":"2016062119392443000_23.6.R229.29","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021314"},{"key":"2016062119392443000_23.6.R229.30","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000112297.72510.32"},{"key":"2016062119392443000_23.6.R229.31","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1211"},{"key":"2016062119392443000_23.6.R229.32","unstructured":"Giusti F Marini F Brandi ML 1993 Multiple endocrine neoplasia type 1. 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