{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:26:47Z","timestamp":1785929207015,"version":"3.56.0"},"reference-count":34,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>Acromegaly has traditionally been regarded as a monomorphous disorder resulting from a benign pituitary adenoma. Increasing evidence, however, is highlighting that this disorder is associated with a spectrum of morphologically distinct pituitary tumors with variable clinical, biochemical and radiologic features and differing therapeutic outcomes that are attributed to different genetic and epigenetic changes. These data underscore the need for developing a more refined clinicopathological risk stratification system and implementing personalized targeted therapeutic approaches.<\/jats:p>","DOI":"10.1530\/erc-16-0496","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T20:51:11Z","timestamp":1485377471000},"page":"C1-C4","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":45,"title":["Pituitary acromegaly: not one disease"],"prefix":"10.1530","volume":"24","author":[{"given":"Sylvia L","family":"Asa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Kucharczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shereen","family":"Ezzat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2017022417252535000_24.3.C1.1","unstructured":"Asa SL 2011 Tumors of the Pituitary Gland. AFIP Atlas of Tumor Pathology, Series 4, Fascicle 15. Ed Silverberg SG . Silver Spring, MD, USA: ARP Press."},{"key":"2017022417252535000_24.3.C1.2","doi-asserted-by":"publisher","DOI":"10.1210\/er.19.6.798"},{"key":"2017022417252535000_24.3.C1.3","doi-asserted-by":"publisher","DOI":"10.1038\/nrc926"},{"key":"2017022417252535000_24.3.C1.4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092259"},{"key":"2017022417252535000_24.3.C1.5","unstructured":"Asa SL Mete O 2016 The pituitary gland. In Endocrine Pathology, pp 315\u2013397. Eds Mete O Asa SL . Cambridge, UK: Cambridge University Press."},{"key":"2017022417252535000_24.3.C1.6","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-0219"},{"key":"2017022417252535000_24.3.C1.7","unstructured":"Bakir B Chan M Cruz JP Kartal MGD Gulenchyn KY Kucharczyk W Salmaslioglu A Yu E 2016 Radiological imaging. In Endocrine Pathology, pp 109\u2013214. Eds Mete O Asa SL . Cambridge, UK: Cambridge University Press."},{"key":"2017022417252535000_24.3.C1.8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0998"},{"key":"2017022417252535000_24.3.C1.9","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-012-0445-1"},{"key":"2017022417252535000_24.3.C1.10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2145"},{"key":"2017022417252535000_24.3.C1.11","doi-asserted-by":"crossref","first-page":"e73543","DOI":"10.1371\/journal.pone.0073543","article-title":"Metabolic glucose status and pituitary pathology portend therapeutic outcomes in acromegaly","volume":"8","author":"Cheng","year":"2013","journal-title":"PLoS ONE"},{"key":"2017022417252535000_24.3.C1.12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2556"},{"key":"2017022417252535000_24.3.C1.13","doi-asserted-by":"crossref","first-page":"e0117107","DOI":"10.1371\/journal.pone.0117107","article-title":"Regulation of aryl hydrocarbon receptor interacting protein (AIP) protein expression by MiR-34a in sporadic somatotropinomas","volume":"10","author":"Denes","year":"2015","journal-title":"PLoS ONE"},{"key":"2017022417252535000_24.3.C1.14","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1330686"},{"key":"2017022417252535000_24.3.C1.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04163.x"},{"key":"2017022417252535000_24.3.C1.16","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2282020695"},{"key":"2017022417252535000_24.3.C1.17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ghir.2016.08.002","article-title":"Genetics of gigantism and acromegaly","volume":"30\u201331","author":"Hannah-Shmouni","year":"2016","journal-title":"Growth Hormone & IGF Research"},{"key":"2017022417252535000_24.3.C1.18","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0689"},{"key":"2017022417252535000_24.3.C1.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04286.x"},{"key":"2017022417252535000_24.3.C1.20","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0832"},{"key":"2017022417252535000_24.3.C1.21","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ11-0177"},{"key":"2017022417252535000_24.3.C1.22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s12020-014-0383-y","article-title":"Growth hormone tumor histological subtypes predict response to surgical and medical therapy","volume":"49","author":"Kiseljak-Vassiliades","year":"2015","journal-title":"Endocrine"},{"key":"2017022417252535000_24.3.C1.23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.mce.2015.09.016","article-title":"Differential somatostatin receptor (SSTR) 1-5 expression and downstream effectors in histologic subtypes of growth hormone pituitary tumors","volume":"417","author":"Kiseljak-Vassiliades","year":"2015","journal-title":"Molecular and Cellular Endocrinology"},{"key":"2017022417252535000_24.3.C1.24","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0864"},{"key":"2017022417252535000_24.3.C1.25","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2015.20"},{"key":"2017022417252535000_24.3.C1.26","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0134"},{"key":"2017022417252535000_24.3.C1.27","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.151"},{"key":"2017022417252535000_24.3.C1.28","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-008-9029-z"},{"key":"2017022417252535000_24.3.C1.29","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-16-0356"},{"key":"2017022417252535000_24.3.C1.30","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3166"},{"key":"2017022417252535000_24.3.C1.31","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-9-3-357"},{"key":"2017022417252535000_24.3.C1.32","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-6-1421"},{"key":"2017022417252535000_24.3.C1.33","doi-asserted-by":"crossref","first-page":"e1002400","DOI":"10.1371\/journal.pgen.1002400","article-title":"The FGFR4-G388R polymorphism promotes mitochondrial STAT3 serine phosphorylation to facilitate pituitary growth hormone cell tumorigenesis","volume":"7","author":"Tateno","year":"2011","journal-title":"PLoS Genetics"},{"key":"2017022417252535000_24.3.C1.34","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0026-0495(96)90082-7","article-title":"Relationships between pathological diagnosis and clinical parameters in acromegaly","volume":"45","author":"Trouillas","year":"1996","journal-title":"Metabolism"}],"container-title":["Endocrine-Related Cancer"],"original-title":[],"link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/24\/3\/C1.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1530\/ERC-16-0496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:54:01Z","timestamp":1784555641000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/erc\/article\/24\/3\/C1-C4\/26998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":34,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/erc-16-0496","relation":{},"ISSN":["1351-0088","1479-6821"],"issn-type":[{"value":"1351-0088","type":"print"},{"value":"1479-6821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}