{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:09:27Z","timestamp":1792084167519,"version":"4.4.0"},"reference-count":44,"publisher":"Bioscientifica","issue":"9","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>\n                    Hashimoto\u2019s thyroiditis (HT) seems to have favourable prognostic impact on papillary thyroid cancer (PTC), but data were obtained analysing all disease stages. Given that HT-related microenvironment involves solely the thyroid, we aimed to assess the relationship between HT, as detected through pathological assessment, and outcome in intrathyroidal PTC. This was a multicentre, retrospective, observational study including 301 PTC with no evidence of extrathyroidal disease. Primary study endpoint was the rate of clinical remission. Auxiliary endpoint was recurrence-free survival (RFS). HT was detected in 42.5% of the cohort and was associated to female gender, smaller tumour size, lower rate of aggressive PTC variants and less frequent post-surgery radio-iodine administration. HT showed relationship with significantly higher rate of clinical remission (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001, OR 4, 95% CI 1.78\u20138.94). PTCs with concomitant HT had significantly longer RFS, as compared with non-HT tumours (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.004). After adjustment for other parameters affecting disease outcome at univariate analysis (age at diagnosis, histology, tumour size and multifocality), prognostic effect of HT remained significant (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.006, OR 3.28, 95% CI 1.39\u20137.72). To verify whether HT could optimise the identification of PTCs with unfavourable outcome, we assessed the accuracy of \u2018non-HT status\u2019 as negative prognostic marker, demonstrating poor capability of identifying patients not maintaining clinical remission until final follow-up (probability of no clinical remission in PTCs without HT: 21.05%, 95% CI 15.20\u201327.93). In conclusion, our data show that HT represents an independent prognostic parameter in intrathyroidal PTC, but cannot improve prognostic specificity.\n                  <\/jats:p>","DOI":"10.1530\/erc-17-0085","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T11:27:05Z","timestamp":1499772425000},"page":"485-493","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":60,"title":["Hashimoto\u2019s thyroiditis predicts outcome in intrathyroidal papillary thyroid cancer"],"prefix":"10.1530","volume":"24","author":[{"given":"Vincenzo","family":"Marotta","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and SurgeryFederico II University, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Sciammarella","sequence":"additional","affiliation":[{"name":"IOS & COLEMAN SrlNaples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Chiofalo","sequence":"additional","affiliation":[{"name":"Thyroid and Parathyroid Surgery UnitIstituto Nazionale per lo Studio e la Cura dei Tumori-IRCCS \u2018Fondazione G. Pascale\u2019, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Gambardella","sequence":"additional","affiliation":[{"name":"Department of AnesthesiologicSurgical and Emergency Sciences, Division of General and Oncologic Surgery, University of Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Bellevicine","sequence":"additional","affiliation":[{"name":"Department of Public HealthUniversity of Naples \u2018Federico II,\u2019, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marica","family":"Grasso","sequence":"additional","affiliation":[{"name":"San Giovanni di Dio e Ruggi D\u2019AragonaUniversitary Hospital, Division of General Surgery, University of Salerno, Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Conzo","sequence":"additional","affiliation":[{"name":"Department of AnesthesiologicSurgical and Emergency Sciences, Division of General and Oncologic Surgery, University of Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Docimo","sequence":"additional","affiliation":[{"name":"Department of AnesthesiologicSurgical and Emergency Sciences, Division of General and Oncologic Surgery, University of Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Botti","sequence":"additional","affiliation":[{"name":"Department of PathologyIstituto Nazionale per lo Studio e la Cura dei Tumori-IRCCS \u2018Fondazione G. 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Pascale\u2019, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Troncone","sequence":"additional","affiliation":[{"name":"Department of Public HealthUniversity of Naples \u2018Federico II,\u2019, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"De Palma","sequence":"additional","affiliation":[{"name":"Dipartimento Chirurgico Generale e PolispecialisticoChirurgia 2, AORN Cardarelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Giacomelli","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze ChirurgicheUniversit\u00e0 di Roma Sapienza, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Pezzullo","sequence":"additional","affiliation":[{"name":"Thyroid and Parathyroid Surgery UnitIstituto Nazionale per lo Studio e la Cura dei Tumori-IRCCS \u2018Fondazione G. 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