{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:20:26Z","timestamp":1784557226751,"version":"3.55.0"},"reference-count":38,"publisher":"Bioscientifica","issue":"7","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>\n                    Parathyroid tumors deregulate microRNAs belonging to the two clusters on the chromosome 19, the C19MC and miR-371-373 clusters. Here, we report that the embryonic miR-372 is aberrantly expressed in half of parathyroid adenomas (PAds) in most of atypical adenomas and carcinomas (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200915). Through\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization, we identified that miR-372-positive parathyroid tumor cells were scattered throughout the tumor parenchyma. In PAd-derived cells, ectopic miR-372 inhibited the expression of its targets\n                    <jats:italic>CDKN1A<\/jats:italic>\n                    \/p21 and LATS2 at both mRNA and protein levels. Although the viability of parathyroid cells was not affected by miR-372 overexpression, the miRNA blunted camptothecin-induced apoptosis in primary PAd-derived cultures. miR-372 overexpression in parathyroid tumor cells increased parathormone (\n                    <jats:italic>PTH<\/jats:italic>\n                    ) mRNA levels, and it positively correlated\n                    <jats:italic>in vivo<\/jats:italic>\n                    with circulating PTH levels. Conversely, the parathyroid-specific genes\n                    <jats:italic>TBX1<\/jats:italic>\n                    and\n                    <jats:italic>GCM2<\/jats:italic>\n                    were not affected by miR-372 mimic transfection. Finally, miR-372 dampened the Wnt pathway in parathyroid tumor cells through DKK1 upregulation. In conclusion, miR-372 is a novel mechanism exploited by a subset of parathyroid tumor cells to partially decrease sensitivity to apoptosis, to increase PTH synthesis and to deregulate Wnt signaling.\n                  <\/jats:p>","DOI":"10.1530\/erc-17-0204","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T14:23:39Z","timestamp":1525357419000},"page":"761-771","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":17,"title":["The aberrantly expressed miR-372 partly impairs sensitivity to apoptosis in parathyroid tumor cells"],"prefix":"10.1530","volume":"25","author":[{"given":"Chiara","family":"Verdelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Forno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Morotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Creo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Guarnieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Scillitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Cetani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Vicentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Balza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Beretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Ferrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Vaira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Corbetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref251","first-page":"170","article-title":"Elucidating the roles of miR-372 in cell proliferation and apoptosis of nasopharyngeal carcinoma TW01 cells","volume":"36","year":"2014","journal-title":"Experimental Oncology"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/onc.2011.209","article-title":"miR-296 regulation of a cell polarity-cell plasticity module controls tumor progression","volume":"31","year":"2012b","journal-title":"Oncogene"},{"key":"ref11","first-page":"128","article-title":"Parathyroid carcinoma","year":"2004","journal-title":"Pathology and Genetics. 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