{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:41:08Z","timestamp":1785404468035,"version":"3.56.0"},"reference-count":156,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>\n                    In this review, the importance of the\n                    <jats:italic>DICER1<\/jats:italic>\n                    gene in the function of endocrine cells is discussed. There is conclusive evidence that\n                    <jats:italic>DICER1<\/jats:italic>\n                    mutations play a crucial role in the development, progression, cell proliferation, therapeutic responsiveness and behavior of several endocrine tumors. We review the literature of\n                    <jats:italic>DICER1<\/jats:italic>\n                    gene mutations in thyroid, parathyroid, pituitary, pineal gland, endocrine pancreas, paragangliomas, medullary, adrenocortical, ovarian and testicular tumors. Although significant progress has been made during the last few years, much more work is needed to fully understand the significance of\n                    <jats:italic>DICER1<\/jats:italic>\n                    mutations.\n                  <\/jats:p>","DOI":"10.1530\/erc-17-0509","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T20:20:11Z","timestamp":1515788411000},"page":"R197-R208","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":39,"title":["DICER1 gene mutations in endocrine tumors"],"prefix":"10.1530","volume":"25","author":[{"given":"Michael","family":"Solarski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Rotondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D","family":"Foulkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Priest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis V","family":"Syro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriett","family":"Butz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D","family":"Cusimano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalman","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref1281","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1752-1947-8-112","article-title":"A novel DICER1 mutation identified in a female with ovarian Sertoli-Leydig cell tumor and multinodular goiter: a case report","volume":"8","year":"2014","journal-title":"Journal of Medical Case Reports"},{"key":"ref641","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/emboj.2011.31","article-title":"Re-dicing the pancreatic \u03b2-cell: do microRNAs define cellular identity?","volume":"30","year":"2011","journal-title":"EMBO Journal"},{"key":"ref1301","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/jc.2015-2169","article-title":"DICER1 mutations and differentiated thyroid carcinoma: evidence of a direct association","volume":"101","year":"2016","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref971","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1582-4934.2003.tb00249.x","article-title":"Sertoli-Leydig cell tumor \u2013 a rare androgen secreting ovarian tumor in postmenopausal women: case report and review of literature","volume":"7","year":"2003","journal-title":"Journal of Cellular and Molecular 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