{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:19:09Z","timestamp":1784557149691,"version":"3.55.0"},"reference-count":146,"publisher":"Bioscientifica","issue":"6","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>\n                    Male breast cancer (MBC) is a rare disease but, as a result of epidemiological collaborations, there is now greater clarity concerning endocrine risk factors. The significant rise in global age-standardised mean BMI in men is likely to lead to increases in incidence of maturity-onset diabetes and MBC. The metabolic changes accompanying obesity decrease androgens and sex hormone-binding globulin (SHBG), thereby increasing available oestrogens. The higher rates of MBC in North and Equatorial Africa are largely due to liver damage from endemic bilharziasis and hepatitis B causing elevated oestradiol (E\n                    <jats:sub>2<\/jats:sub>\n                    ) levels from hepatic conversion of androgen. Klinefelter\u2019s syndrome (XXY) is associated with a 50-fold increase in incidence of MBC compared with XY males, and this is the most pronounced evidence for testicular malfunction amplifying risk. Delay in presentation means that up to 40% of cases have stage III or stage IV disease at diagnosis. No randomised controlled trials have been reported on endocrine treatment of advanced disease or adjuvant\/neoadjuvant therapy following or preceding surgery. Tamoxifen is the most effective endocrine therapy, but side effects can lead to non-compliance in a substantial number of men. Aromatase inhibitors are less effective because they do not inhibit testicular oestrogen production. There is an urgent need for collaborative trials to provide an evidence base for the most effective endocrine and least toxic therapies for men with breast cancer.\n                  <\/jats:p>","DOI":"10.1530\/erc-18-0117","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T13:55:25Z","timestamp":1526046925000},"page":"R365-R373","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":23,"title":["The endocrinology of male breast cancer"],"prefix":"10.1530","volume":"25","author":[{"given":"Ian S","family":"Fentiman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref921","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1001\/archsurg.1973.01350150013005","article-title":"Carcinoma of the male breast. 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Australian comparison","volume":"194","year":"2011","journal-title":"Medical Journal of Australia"},{"key":"ref691","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3747\/co.v17i5.631","article-title":"Endocrine therapy for male breast cancer: rates of toxicity and adherence.","volume":"17","year":"2010","journal-title":"Current Oncology"},{"key":"ref551","first-page":"53","article-title":"Invitation to attend a health check in a general practice setting: comparison of attenders and non-attenders","volume":"38","year":"1988","journal-title":"Journal of the Royal College of General Practitioners"},{"key":"ref251","first-page":"39","article-title":"Use of tamoxifen with postsurgical irradiation may improve survival in estrogen and progesterone receptor\u2013positive male breast cancer","volume":"11","year":"2010","journal-title":"Clinical Breast Cancer"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S0140-6736(78)92925-2","article-title":"Tamoxifen and male breast cancer","volume":"312","year":"1978","journal-title":"Lancet"},{"key":"ref231","first-page":"467","article-title":"Risk factors for male breast cancer \u2013 a case-control study from Scandinavia","volume":"40","year":"2001","journal-title":"Acta Oncologica"},{"key":"ref871","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1056\/NEJMoa040331","article-title":"A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer","volume":"350","year":"2004","journal-title":"New England Journal of Medicine"},{"key":"ref1121","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1023\/A:1008869003012","article-title":"Risk factors for male breast cancer (United States).","volume":"9","year":"1998","journal-title":"Cancer Causes Control"},{"key":"ref391","first-page":"4293","article-title":"Prevalence of Klinefelter's syndrome in male breast cancer patients","volume":"17","year":"1997","journal-title":"Anticancer Research"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/1097-0142(19940701)74:1<74::AID-CNCR2820740113>3.0.CO;2-#","article-title":"Tamoxifen administration is associated with a high rate of treatment-limiting symptoms in male breast cancer patients","volume":"74","year":"1994","journal-title":"Cancer"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0009-9260(83)80408-5","article-title":"Tamoxifen in the treatment of male breast carcinoma","volume":"34","year":"1983","journal-title":"Clinical Radiology"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1186\/bcr2258","article-title":"Immunohistochemical characterization of subtypes of male breast carcinoma","volume":"11","year":"2009","journal-title":"Breast Cancer Research"},{"key":"ref1281","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1093\/annonc\/mdr459","article-title":"Retrospective review of male breast cancer patients: analysis of tamoxifen-related side-effects","volume":"23","year":"2012","journal-title":"Annals of Oncology"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1056\/NEJMoa040331","article-title":"A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer","volume":"350","year":"2004","journal-title":"New England Journal of Medicine"},{"key":"ref961","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/bjc.1963.75","article-title":"On Bilharziasis and male breast cancer in Egypt: a preliminary report and review of the literature.","volume":"17","year":"1963","journal-title":"British Journal of 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