{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:28:48Z","timestamp":1791296928299,"version":"4.1.0"},"reference-count":36,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n                    Tumours of the anterior pituitary can manifest from all endocrine cell types but the mechanisms for determining their specification are not known. The Hippo kinase cascade is a crucial signalling pathway regulating growth and cell fate in numerous organs. There is mounting evidence implicating this in tumour formation, where it is emerging as an anti-cancer target. We previously demonstrated activity of the Hippo kinase cascade in the mouse pituitary and nuclear association of its effectors YAP\/TAZ with SOX2-expressing pituitary stem cells. Here, we sought to investigate whether these components are expressed in the human pituitary and if they are deregulated in human pituitary tumours. Analysis of pathway components by immunofluorescence reveals pathway activity during normal human pituitary development and in the adult gland. Poorly differentiated pituitary tumours (null-cell adenomas, adamantinomatous craniopharyngiomas (ACPs) and papillary craniopharyngiomas (PCPs)), displayed enhanced expression of pathway effectors YAP\/TAZ. In contrast, differentiated adenomas displayed lower or absent levels. Knockdown of the kinase-encoding\n                    <jats:italic>Lats1<\/jats:italic>\n                    in GH3 rat mammosomatotropinoma cells suppressed\n                    <jats:italic>Prl<\/jats:italic>\n                    and\n                    <jats:italic>Gh<\/jats:italic>\n                    promoter activity following an increase in YAP\/TAZ levels. In conclusion, we have demonstrated activity of the Hippo kinase cascade in the human pituitary and association of high YAP\/TAZ with repression of the differentiated state both\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Characterisation of this pathway in pituitary tumours is of potential prognostic value, opening up putative avenues for treatments.\n                  <\/jats:p>","DOI":"10.1530\/erc-18-0330","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T10:55:20Z","timestamp":1535021720000},"page":"215-225","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":23,"title":["Non-secreting pituitary tumours characterised by enhanced expression of YAP\/TAZ"],"prefix":"10.1530","volume":"26","author":[{"given":"Paraskevi","family":"Xekouki","sequence":"first","affiliation":[{"name":"1Centre for Craniofacial and Regenerative Biology, King\u2019s College London, London, UK"},{"name":"2Department of Endocrinology, King\u2019s College Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J","family":"Lodge","sequence":"additional","affiliation":[{"name":"1Centre for Craniofacial and Regenerative Biology, King\u2019s College London, London, UK"},{"name":"3Department of Endocrinology and Diabetes, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Matschke","sequence":"additional","affiliation":[{"name":"4Institute of Neuropathology, University Hospital Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Santambrogio","sequence":"additional","affiliation":[{"name":"1Centre for Craniofacial and Regenerative Biology, King\u2019s College London, London, UK"},{"name":"5Department of Internal Medicine III, Carl Gustav Carus Medical School, Technical University of Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Apps","sequence":"additional","affiliation":[{"name":"6Birth Defects Research Centre, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, University College London, London, UK"},{"name":"7Histopathology Department, Great Ormond Street Hospital NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Sharif","sequence":"additional","affiliation":[{"name":"8Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm U1172, Jean-Pierre Aubert Research Centre, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S","family":"Jacques","sequence":"additional","affiliation":[{"name":"6Birth Defects Research Centre, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, University College London, London, UK"},{"name":"7Histopathology Department, Great Ormond Street Hospital NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Aylwin","sequence":"additional","affiliation":[{"name":"2Department of Endocrinology, King\u2019s College Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Prevot","sequence":"additional","affiliation":[{"name":"8Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm U1172, Jean-Pierre Aubert Research Centre, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[{"name":"9Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Flitsch","sequence":"additional","affiliation":[{"name":"10Department of Neurosurgery, Hamburg University Medical Center, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan R","family":"Bornstein","sequence":"additional","affiliation":[{"name":"3Department of Endocrinology and Diabetes, King\u2019s College London, London, UK"},{"name":"5Department of Internal Medicine III, Carl Gustav Carus Medical School, Technical University of Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marily","family":"Theodoropoulou","sequence":"additional","affiliation":[{"name":"11Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia L","family":"Andoniadou","sequence":"additional","affiliation":[{"name":"1Centre for Craniofacial and Regenerative Biology, King\u2019s College London, London, UK"},{"name":"5Department of Internal Medicine III, Carl Gustav Carus Medical School, Technical University of Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref181","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1001\/jama.2016.19699","article-title":"Diagnosis and treatment of pituitary adenomas","volume":"317","year":"2017","journal-title":"JAMA"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"11961","DOI":"10.1038\/ncomms11961","article-title":"LATS-YAP\/TAZ controls lineage specification by regulating TGF\u03b2 signaling and Hnf4\u03b1 expression during liver development","volume":"7","year":"2016","journal-title":"Nature Communications"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s12022-017-9498-z","article-title":"Overview of the 2017 WHO classification of pituitary tumors","volume":"28","year":"2017","journal-title":"Endocrine Pathology"},{"key":"ref211","first-page":"451","article-title":"Regulation of Hippo Signaling by EGFR-MAPK Signaling through Ajuba Family 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regulates Wnt\/beta-catenin signaling","volume":"18","year":"2010","journal-title":"Developmental Cell"}],"container-title":["Endocrine-Related Cancer"],"original-title":[],"link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/26\/1\/ERC-18-0330.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/erc.bioscientifica.com\/downloadpdf\/journals\/erc\/26\/1\/ERC-18-0330.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:55:04Z","timestamp":1784555704000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/erc\/article\/26\/1\/215-225\/25383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":36,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/erc-18-0330","relation":{},"ISSN":["1351-0088","1479-6821"],"issn-type":[{"value":"1351-0088","type":"print"},{"value":"1479-6821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}