{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:42:35Z","timestamp":1787974955872,"version":"build-2784847793"},"reference-count":120,"publisher":"Bioscientifica","issue":"5","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>\n                    Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an encapsulated or clearly delimited, noninvasive neoplasm with a follicular growth pattern and nuclear features of papillary thyroid carcinoma (PTC). It is considered a \u2018pre-malignant\u2019 lesion of the\n                    <jats:italic>RAS<\/jats:italic>\n                    -like group. Ultrasonography (US), cytology and molecular tests are useful to suspect thyroid nodules that correspond to NIFTP but there is wide overlap of the results with the encapsulated follicular variant of PTC (E-FVPTC). In these nodules that possibly or likely correspond to NIFTP, if surgery is indicated, lobectomy is favored over total thyroidectomy. The diagnosis of NIFTP is made after complete resection of the lesion by observing well-defined criteria. In the case of patients who received the diagnosis of FVPTC and whose pathology report does not show findings of malignancy (lymph node metastasis, extrathyroidal invasion, vascular\/capsular invasion), if the tumor was encapsulated or well delimited, the slides can be revised by an experienced pathologist to determine whether the diagnostic criteria of NIFTP are met, but special attention must be paid to the adequate representativeness of the capsule and tumor. Since NIFTP is not \u2018malignant\u2019, tumor staging is not necessary and patients are not submitted to thyroid cancer protocols or guidelines. We believe that patients with NIFTP without associated malignancy and without nodules detected by US of the remnant lobe (if submitted to lobectomy) can be managed like those with follicular adenoma.\n                  <\/jats:p>","DOI":"10.1530\/erc-19-0048","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T07:27:28Z","timestamp":1553585248000},"page":"R259-R266","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":58,"title":["Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): a review for clinicians"],"prefix":"10.1530","volume":"26","author":[{"given":"Pedro Weslley","family":"Rosario","sequence":"first","affiliation":[{"name":"Santa Casa de Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Franco","family":"Mour\u00e3o","sequence":"additional","affiliation":[{"name":"Santa Casa de Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref71","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1089\/thy.2017.0500","article-title":"The 2017 Bethesda system for reporting thyroid cytopathology","volume":"27","year":"2017","journal-title":"Thyroid"},{"key":"ref1041","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/cen.12387","article-title":"Noninvasive encapsulated follicular variant of papillary thyroid carcinoma: is lobectomy sufficient for tumours \u22651\u2009cm?","volume":"81","year":"2014","journal-title":"Clinical Endocrinology"},{"key":"ref1211","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/cncy.21839","article-title":"Cytological, molecular, and clinical features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features versus invasive forms of follicular variant of papillary thyroid carcinoma","volume":"125","year":"2017","journal-title":"Cancer Cytopathology"},{"key":"ref511","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/modpathol.2016.65","article-title":"Ninety-four cases of encapsulated follicular variant of papillary thyroid carcinoma: a name change to noninvasive follicular thyroid neoplasm with papillary-like nuclear features would help prevent overtreatment","volume":"29","year":"2016","journal-title":"Modern Pathology"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s12020-018-1585-5","article-title":"Impact of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) on the risk of malignancy estimated by the ultrasonographic classification of the American Thyroid Association (ATA) in thyroid nodules >1\u2009cm","volume":"60","year":"2018c","journal-title":"Endocrine"},{"key":"ref961","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/cen.13523","article-title":"Is 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