{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:39:33Z","timestamp":1793111973858,"version":"4.5.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"11","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,11]]},"abstract":"\n ALK fusions are found in various tumors, including thyroid cancer, and serve as a diagnostic marker and therapeutic target. Spectrum and outcomes of\n ALK<\/jats:italic>\n fusions found in thyroid nodules and cancer are not fully characterized. We report a series of 44\n ALK<\/jats:italic>\n -translocated thyroid neoplasms, including 31 identified preoperatively in thyroid fine-needle aspirates (FNA). The average patients\u2019 age was 43 years (range, 8\u201376 years); only one with radiation history. All 19 resected thyroid nodules with\n ALK<\/jats:italic>\n fusion identified preoperatively were malignant. Among nodules with known surgical pathology (\n n<\/jats:italic>\n \u2009=\u200932), 84% were papillary thyroid carcinomas (PTCs) and 16% poorly differentiated thyroid carcinomas (PDTCs). PTCs showed infiltrative growth with follicular architecture seen exclusively (30%) or in combination with papillary and\/or solid growth (37%). Tumor multifocality was seen in 10 (31%) PTC cases. Most PDTC had a well-differentiated PTC component. Lymph node metastases were identified in 10\/18 (56%) patients with neck dissection. The most common\n ALK<\/jats:italic>\n fusion partners were\n STRN<\/jats:italic>\n (n\u2009=\u200922) and\n EML4<\/jats:italic>\n (n\u2009=\u200917). In five cases, novel\n ALK<\/jats:italic>\n fusion partners were discovered. All five PDTCs carried\n STRN-ALK<\/jats:italic>\n fusion. On follow-up, ten patients were free of disease at 2\u2013108 months, whereas two patients with PDTC died of disease. In summary,\n ALK<\/jats:italic>\n fusion-positive thyroid carcinomas are typically infiltrative PTC with common follicular growth, which may show tumor dedifferentiation associated with increased mortality. Compared to\n EML4-ALK<\/jats:italic>\n ,\n STRN-ALK<\/jats:italic>\n may be more common in PDTC, and ~10% of\n ALK<\/jats:italic>\n fusions occur to rare gene partners. When\n ALK<\/jats:italic>\n fusion is detected preoperatively in FNA samples, malignancy should be expected.\n <\/jats:p>","DOI":"10.1530\/erc-19-0325","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T06:36:55Z","timestamp":1568961415000},"page":"803-814","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":68,"title":["Characterization of thyroid cancer driven by known and novel ALK fusions"],"prefix":"10.1530","volume":"26","author":[{"given":"Federica","family":"Panebianco","sequence":"first","affiliation":[{"name":"1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyaksandr V","family":"Nikitski","sequence":"additional","affiliation":[{"name":"1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina N","family":"Nikiforova","sequence":"additional","affiliation":[{"name":"1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihan","family":"Kaya","sequence":"additional","affiliation":[{"name":"1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linwah","family":"Yip","sequence":"additional","affiliation":[{"name":"2Division of Endocrine Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Condello","sequence":"additional","affiliation":[{"name":"1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail I","family":"Wald","sequence":"additional","affiliation":[{"name":"1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri E","family":"Nikiforov","sequence":"additional","affiliation":[{"name":"1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simion I","family":"Chiosea","sequence":"additional","affiliation":[{"name":"1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine-Related Cancer"],"original-title":[],"link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/26\/11\/ERC-19-0325.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/erc.bioscientifica.com\/downloadpdf\/journals\/erc\/26\/11\/ERC-19-0325.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:55:25Z","timestamp":1784555725000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/erc\/article\/26\/11\/803-814\/25266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":0,"journal-issue":{"issue":"11"},"URL":"https:\/\/doi.org\/10.1530\/erc-19-0325","relation":{},"ISSN":["1351-0088","1479-6821"],"issn-type":[{"value":"1351-0088","type":"print"},{"value":"1479-6821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11]]}}}