{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:41:35Z","timestamp":1791312095872,"version":"4.3.1"},"reference-count":0,"publisher":"Bioscientifica","issue":"7","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>\n                    Identifying the factors stimulating prostate cancer cells migration and invasion has the potential to bring new therapeutic targets to the clinic. Cysteine-rich secretory protein 3 (CRISP3) is one of the most highly upregulated proteins during the transition of a healthy human prostatic epithelium to prostate cancer. Here we show using a genetically engineered mouse model of prostate cancer that CRISP3 production greatly facilitates disease progression from carcinoma\n                    <jats:italic>in situ<\/jats:italic>\n                    to invasive prostate cancer\n                    <jats:italic>in vivo<\/jats:italic>\n                    . This interpretation was confirmed using both human and mouse prostate cancer cell lines, which showed that exposure to CRISP3 enhanced cell motility and invasion. Further, using mass spectrometry, we show that CRISP3 induces changes in abundance of a subset of cell-cell adhesion proteins, including LASP1 and TJP1 both\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Collectively, these data identify CRISP3 as being pro-tumorigenic in the prostate and validate it as a potential target for therapeutic intervention.\n                  <\/jats:p>","DOI":"10.1530\/erc-20-0092","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T12:16:44Z","timestamp":1588335404000},"page":"415-430","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":30,"title":["CRISP3 expression drives prostate cancer invasion and progression"],"prefix":"10.1530","volume":"27","author":[{"given":"Marianna","family":"Volpert","sequence":"first","affiliation":[{"name":"1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Furic","sequence":"additional","affiliation":[{"name":"1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia"},{"name":"2Prostate Cancer Translational Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia"},{"name":"3Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia"},{"name":"4Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Hu","sequence":"additional","affiliation":[{"name":"1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia"},{"name":"5The School of Biological Sciences, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia"},{"name":"5The School of Biological Sciences, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Rebello","sequence":"additional","affiliation":[{"name":"1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivakumar","family":"Keerthikumar","sequence":"additional","affiliation":[{"name":"2Prostate Cancer Translational Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia"},{"name":"3Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia"},{"name":"6Computational Cancer Biology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemma","family":"Evans","sequence":"additional","affiliation":[{"name":"7The Hudson Institute of Medical Research, Clayton, Victoria, Australia"},{"name":"8Department of Physiology, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D Jo","family":"Merriner","sequence":"additional","affiliation":[{"name":"1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia"},{"name":"5The School of Biological Sciences, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Pedersen","sequence":"additional","affiliation":[{"name":"1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail P","family":"Risbridger","sequence":"additional","affiliation":[{"name":"1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia"},{"name":"2Prostate Cancer Translational Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia"},{"name":"3Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia"},{"name":"4Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"McIntyre","sequence":"additional","affiliation":[{"name":"9Health Innovations Research Institute and School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moira K","family":"O\u2019Bryan","sequence":"additional","affiliation":[{"name":"1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia"},{"name":"5The School of Biological Sciences, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine-Related Cancer"],"original-title":[],"link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/27\/7\/ERC-20-0092.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/erc.bioscientifica.com\/downloadpdf\/journals\/erc\/27\/7\/ERC-20-0092.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:55:39Z","timestamp":1784555739000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/erc\/article\/27\/7\/415-430\/25485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":0,"journal-issue":{"issue":"7"},"URL":"https:\/\/doi.org\/10.1530\/erc-20-0092","relation":{},"ISSN":["1351-0088","1479-6821"],"issn-type":[{"value":"1351-0088","type":"print"},{"value":"1479-6821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]}}}