{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:19:58Z","timestamp":1784557198399,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"10","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10]]},"abstract":"\n Cardiomyopathy is a frequent complication of pheochromocytoma, and echocardiography is the most accessible method for its evaluation. The objective of this study was to assess the clinical significance of classical and novel echocardiographic parameters of cardiac function in 24 patients with pheochromocytomas (PPGL) compared to 24 subjects with essential hypertension (EH). Fourteen PPGL patients were reassessed after successful surgery. Left ventricular hypertrophy was four times more prevalent in patients with PPGL vs EH (75% vs 17%;\n P<\/jats:italic>\n \u2009=\u20090.00005). Left ventricular mass index (LVMi) significantly correlated with urine metanephrine (MN) (\n rs<\/jats:italic>\n \u2009=\u20090.452,\n P<\/jats:italic>\n \u2009=\u20090.00127) and normetanephrine (NMN) (\n rs<\/jats:italic>\n \u2009=\u20090.484,\n P<\/jats:italic>\n \u2009=\u20090.00049). Ejection fraction (EF) and endocardial fractional shortening (EFS) were normal in all participants and did not correlate with urine metanephrines. Global longitudinal strain (GLS) was significantly lower in PPGL compared to EH group (\u221216.54 \u00b1 1.83 vs \u221219.43 \u00b1 2.19;\n P<\/jats:italic>\n < 0.00001) and revealed a moderate significant positive correlations with age (\n rs<\/jats:italic>\n \u2009=\u20090.489;\n P<\/jats:italic>\n \u2009=\u20090.015), LVMi (\n rs<\/jats:italic>\n \u2009=\u20090.576,\n P<\/jats:italic>\n < 0.0001), MN (\n rs<\/jats:italic>\n \u2009=\u20090.502,\n P<\/jats:italic>\n \u2009=\u20090.00028) and NMN (\n rs<\/jats:italic>\n \u2009=\u20090.580,\n P<\/jats:italic>\n < 0.0001). Relative wall thickness (RWT) showed a strong positive correlation with urine MN (\n rs<\/jats:italic>\n \u2009=\u20090.559,\n P<\/jats:italic>\n < 0.0001) and NMN (\n rs<\/jats:italic>\n \u2009=\u20090.689,\n P<\/jats:italic>\n < 0.00001). Markedly decreased LVMi (118.2 \u00b1 26.9 vs 102.9 \u00b1 22.3;\n P<\/jats:italic>\n \u2009=\u20090.007) and significant improvement in GLS (\u221216.64 \u00b1 1.49 vs \u221219.57 \u00b1 1.28;\n P<\/jats:italic>\n < 0.001) was observed after surgery. \u0394GLS depended significantly on the follow-up duration. In conclusion, classical echocardiographic parameters usually used for assessment of systolic cardiac function are not reliable tests in pheochromocytoma patients. Instead, GLS seems to be a better predictor for the severity and the reversibility of catecholamine-induced myocardial function damage in these subjects. RWT should be measured routinely as an early indicator of cardiac remodeling.\n <\/jats:p>","DOI":"10.1530\/erc-20-0137","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T05:11:08Z","timestamp":1595394668000},"page":"561-570","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":9,"title":["Global longitudinal strain as a marker for systolic function in patients with pheochromocytomas"],"prefix":"10.1530","volume":"27","author":[{"given":"Atanaska","family":"Elenkova","sequence":"first","affiliation":[{"name":"1Department of Endocrinology, Medical Faculty, Medical University Sofia, Sofia, Bulgaria"},{"name":"2Expert Center for Rare Endocrine Diseases, Sofia, Bulgaria"},{"name":"3European Network on Rare Endocrine Conditions (ENDO-ERN)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabhat","family":"Shabani","sequence":"additional","affiliation":[{"name":"4Alexandrovska Hospital, Medical University \u2013 Sofia, Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Kinova","sequence":"additional","affiliation":[{"name":"5University Hospital \u2018Queen Joanna\u2019, Medical University \u2013 Sofia, Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Vasilev","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Medical Faculty, Medical University Sofia, Sofia, Bulgaria"},{"name":"2Expert Center for Rare Endocrine Diseases, Sofia, Bulgaria"},{"name":"3European Network on Rare Endocrine Conditions (ENDO-ERN)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assen","family":"Goudev","sequence":"additional","affiliation":[{"name":"5University Hospital \u2018Queen Joanna\u2019, Medical University \u2013 Sofia, Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Zacharieva","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Medical Faculty, Medical University Sofia, Sofia, Bulgaria"},{"name":"2Expert Center for Rare Endocrine Diseases, Sofia, Bulgaria"},{"name":"3European Network on Rare Endocrine Conditions (ENDO-ERN)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine-Related Cancer"],"original-title":[],"link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/27\/10\/ERC-20-0137.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/erc.bioscientifica.com\/downloadpdf\/journals\/erc\/27\/10\/ERC-20-0137.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:55:42Z","timestamp":1784555742000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/erc\/article\/27\/10\/561-570\/25360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":0,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.1530\/erc-20-0137","relation":{},"ISSN":["1351-0088","1479-6821"],"issn-type":[{"value":"1351-0088","type":"print"},{"value":"1479-6821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}