{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:48:49Z","timestamp":1792007329574,"version":"4.4.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"11","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>\n                    Emerging data supports a potential role of neurotensin (NT) in the development of obesity, obesity-associated comorbidities, and certain cancers. The association of NT with colon cancer risk has not been explicitly explored. We determined plasma levels of pro-NT, a stable NT precursor fragment, in 223 incident colon cancer patients and 223 age-, gender-, BMI-matched population controls participating in a population-based case\u2013control study of colon cancer. On average, the cases have significantly higher levels of pro-NT than the controls (median\u2009=\u2009205.6 pmol\/L vs 183.1 pmol\/L, respectively;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.02). Multivariate logistic regression models, adjusted for age, gender, BMI, family history of colorectal cancer, smoking, diabetes mellitus, alcohol, and non-steroidal anti-inflammatory drugs use, show statistically significant risk associations: for continuous measure of pro-NT, the OR estimate was 1.30 (95% CI =1.03\u20131.64;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.026) for each increment of 175 pmol\/L; for dichotomized measure of pro-NT, the OR estimate was 1.75 (95% CI\u2009=\u20091.12\u20132.74;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.025) for those in the top quartile comparing to the other participants. Our results support circulating levels of pro-NT as a novel risk biomarker for colon cancer.\n                  <\/jats:p>","DOI":"10.1530\/erc-20-0310","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T07:19:56Z","timestamp":1600067996000},"page":"641-646","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":2,"title":["High plasma levels of pro-NT are associated with increased colon cancer risk"],"prefix":"10.1530","volume":"27","author":[{"given":"Li","family":"Li","sequence":"first","affiliation":[{"name":"1Department of Family Medicine, University of Virginia, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi L","family":"Weiss","sequence":"additional","affiliation":[{"name":"2Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"2Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyi","family":"Chen","sequence":"additional","affiliation":[{"name":"3Case Western Reserve University, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Donato","sequence":"additional","affiliation":[{"name":"4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B Mark","family":"Evers","sequence":"additional","affiliation":[{"name":"2Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine-Related Cancer"],"original-title":[],"link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/27\/11\/ERC-20-0310.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/erc.bioscientifica.com\/downloadpdf\/journals\/erc\/27\/11\/ERC-20-0310.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:55:48Z","timestamp":1784555748000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/erc\/article\/27\/11\/641-646\/25374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":0,"journal-issue":{"issue":"11"},"URL":"https:\/\/doi.org\/10.1530\/erc-20-0310","relation":{},"ISSN":["1351-0088","1479-6821"],"issn-type":[{"value":"1351-0088","type":"print"},{"value":"1479-6821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11]]}}}