{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:07:58Z","timestamp":1792501678329,"version":"4.5.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"10","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:p>\n                    For the past 80 years, radioiodine (\n                    <jats:sup>131<\/jats:sup>\n                    I) has been used to ablate thyroid tissue not removed by surgery or to treat differentiated thyroid cancer that has metastasized to other parts of the body. However, the Na\n                    <jats:sup>+<\/jats:sup>\n                    \/I\n                    <jats:sup>\u2212<\/jats:sup>\n                    symporter (NIS), which mediates active iodide uptake into thyroid follicular cells, is also expressed in several non-thyroidal tissues. This NIS expression permits\n                    <jats:sup>131<\/jats:sup>\n                    I accumulation and radiation damage in these non-target tissues, which accounts for the adverse effects of radioiodine therapy. We will review the data regarding the expression, function, and regulation of NIS in non-thyroidal tissues and explain the seemingly paradoxical adverse effects induced by\n                    <jats:sup>131<\/jats:sup>\n                    I, the self-limited gastrointestinal adverse effects in contrast to the permanent salivary dysfunction that is seen after\n                    <jats:sup>131<\/jats:sup>\n                    I therapy. We propose that prospective studies are needed to uncover the time-course of pathological processes underlying development and progression or ultimate resolution of\n                    <jats:sup>131<\/jats:sup>\n                    I-induced salivary ductal obstruction and nasolacrimal duct obstruction. Finally, preventive measures and early therapeutic interventions that can be applied potentially to eliminate or alleviate long-term radioiodine adverse effects will be discussed.\n                  <\/jats:p>","DOI":"10.1530\/erc-21-0035","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T14:24:47Z","timestamp":1620743087000},"page":"T167-T177","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":19,"title":["Na+\/I\u2212 symporter expression, function, and regulation in non-thyroidal tissues and impact on thyroid cancer therapy"],"prefix":"10.1530","volume":"28","author":[{"given":"Sissy M","family":"Jhiang","sequence":"first","affiliation":[{"name":"1Department of Physiology and Cell Biology, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA"},{"name":"2Department of Internal Medicine, Division of Endocrinology and Metabolism, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A","family":"Sipos","sequence":"additional","affiliation":[{"name":"2Department of Internal Medicine, Division of Endocrinology and Metabolism, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine-Related Cancer"],"original-title":[],"link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/28\/10\/ERC-21-0035.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/erc.bioscientifica.com\/downloadpdf\/journals\/erc\/28\/10\/ERC-21-0035.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:55:58Z","timestamp":1784555758000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/erc\/article\/28\/10\/T167-T177\/25484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,1]]},"references-count":0,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.1530\/erc-21-0035","relation":{},"ISSN":["1351-0088","1479-6821"],"issn-type":[{"value":"1351-0088","type":"print"},{"value":"1479-6821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,1]]}}}