{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:43:02Z","timestamp":1791211382843,"version":"4.1.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"11","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:p>\n                    We aimed to identify presurgical and surgical risk factors for intraoperative complications in patients with pheochromocytomas. A retrospective study of patients with pheochromocytomas who underwent surgery in ten Spanish hospitals between 2011 and 2021 was performed. One hundred and sixty-two surgeries performed in 159 patients were included. The mean age was 51.6 \u00b1 16.4 years old and 52.8% were women. Median tumour size was 40 mm (range 10\u2013110). Laparoscopic adrenalectomy was performed in 148 patients and open adrenalectomy in 14 patients. Presurgical alpha- and beta-blockade was performed in 95.1% and 51.9% of the surgeries, respectively. 33.3% of the patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200954) had one or more intraoperative complications. The most common complication was the hypertensive crisis in 21.0%, followed by prolonged hypotension in 20.0%, and hemodynamic instability in 10.5%. Patients pre-treated with doxazosin required intraoperative hypotensive treatment more commonly than patients pre-treated with other antihypertensive drugs (51.1% vs 26.5%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.002). Intraoperative complications were more common in patients with higher levels of urine metanephrine (\n                    <jats:italic>OR<\/jats:italic>\n                    \u2009=\u20091.01 for each 100 \u03bcg\/24 h,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.026) and normetanephrine (\n                    <jats:italic>OR<\/jats:italic>\n                    \u2009=\u20091.00 for each 100 \u03bcg\/24 h,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.025), larger tumours (\n                    <jats:italic>OR<\/jats:italic>\n                    \u2009=\u20091.4 for each 10 mm,\n                    <jats:italic>P &lt;<\/jats:italic>\n                    0.001), presurgical blood pressure &gt; 130\/80 mmHg (\n                    <jats:italic>OR<\/jats:italic>\n                    \u2009=\u20092.25,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.027), pre-treated with doxazosin (\n                    <jats:italic>OR<\/jats:italic>\n                    \u2009=\u20092.20,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.023) and who had not received perioperative hydrocortisone (\n                    <jats:italic>OR<\/jats:italic>\n                    \u2009=\u20093.95,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.008). In conclusion, intraoperative complications in pheochromocytoma surgery are common and can be potentially life-threatening. Higher metanephrine and normetanephrine levels, larger tumour size, insufficient blood pressure control before surgery, pre-treatment with doxazosin, and the lack of treatment with perioperative hydrocortisone are associated with higher risk of intraoperative complications.\n                  <\/jats:p>","DOI":"10.1530\/erc-21-0230","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T12:42:22Z","timestamp":1628685742000},"page":"695-703","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":30,"title":["Risk factors for intraoperative complications in pheochromocytomas"],"prefix":"10.1530","volume":"28","author":[{"given":"Marta","family":"Araujo-Castro","sequence":"first","affiliation":[{"name":"1Neuroendocrinology Unit, Department of Endocrinology and Nutrition, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRICYS), Hospital Universitario Ram\u00f3n y Cajal, Madrid, Spain"},{"name":"2Department of Health Science, Universidad de Alcal\u00e1, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"Garcia Centeno","sequence":"additional","affiliation":[{"name":"3Department of Endocrinology & Nutrition, Hospital Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-Carmen","family":"L\u00f3pez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"4Department of Endocrinology & Nutrition, Hospital Universitario de Albacete, Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Lamas","sequence":"additional","affiliation":[{"name":"4Department of Endocrinology & Nutrition, Hospital Universitario de Albacete, Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"\u00c1lvarez-Escol\u00e1","sequence":"additional","affiliation":[{"name":"5Department of Endocrinology & Nutrition, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Calatayud Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"6Department of Endocrinology & Nutrition, Hospital Universitario Doce de Octubre, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Blanco-Carrera","sequence":"additional","affiliation":[{"name":"7Department of Endocrinology & Nutrition, Hospital Universitario Pr\u00edncipe de Asturias, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paz","family":"de Miguel Novoa","sequence":"additional","affiliation":[{"name":"8Department of Endocrinology & Nutrition, Hospital Universitario Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Vald\u00e9s","sequence":"additional","affiliation":[{"name":"9Department of Endocrinology & Nutrition, Hospital Universitario de Cabue\u00f1es, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Gracia Gimeno","sequence":"additional","affiliation":[{"name":"10Department of Endocrinology & Nutrition, Hospital Royo Villanova, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Tom\u00e9","family":"Fern\u00e1ndez-Ladreda","sequence":"additional","affiliation":[{"name":"11Department of Endocrinology & Nutrition, Hospital Universitario de Puerto Real, C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"M\u00ednguez Ojeda","sequence":"additional","affiliation":[{"name":"12Department of Urology, IRYCIS, Hospital Universitario Ram\u00f3n y Cajal, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Percovich Hualpa","sequence":"additional","affiliation":[{"name":"3Department of Endocrinology & Nutrition, Hospital Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Mora","sequence":"additional","affiliation":[{"name":"13Department of Endocrinology & Nutrition, Hospital Clinic, Barcelona, Spain"},{"name":"14Group of Endocrine Disorders, Institut d\u2019Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d3scar","family":"Vidal","sequence":"additional","affiliation":[{"name":"15Department of General Surgery, Hospital Clinic, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Serrano Romero","sequence":"additional","affiliation":[{"name":"16Department of Anesthesia, IRYCIS, Hospital Universitario Ram\u00f3n y Cajal, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia Alexandra","family":"Hanzu","sequence":"additional","affiliation":[{"name":"13Department of Endocrinology & Nutrition, Hospital Clinic, Barcelona, Spain"},{"name":"14Group of Endocrine Disorders, Institut d\u2019Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"G\u00f3mez Dos Santos","sequence":"additional","affiliation":[{"name":"12Department of Urology, IRYCIS, Hospital Universitario Ram\u00f3n y Cajal, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine-Related Cancer"],"original-title":[],"link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/28\/11\/ERC-21-0230.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/erc.bioscientifica.com\/downloadpdf\/journals\/erc\/28\/11\/ERC-21-0230.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:56:08Z","timestamp":1784555768000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/erc\/article\/28\/11\/695-703\/25487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,1]]},"references-count":0,"journal-issue":{"issue":"11"},"URL":"https:\/\/doi.org\/10.1530\/erc-21-0230","relation":{},"ISSN":["1351-0088","1479-6821"],"issn-type":[{"value":"1351-0088","type":"print"},{"value":"1479-6821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,1]]}}}