{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:49:09Z","timestamp":1790470149124,"version":"4.1.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p>\n                    Adrenal cortisol-producing tumors can express illicit membrane receptors such as luteinizing hormone (LH), glucose-dependent insulinotropic peptide (GIP) or type 4 and 7 serotonin (5-HT\n                    <jats:sub>4\/7<\/jats:sub>\n                    ) receptors. Abnormal expression of the LH receptor (LH-R) has been ascribed to the activation of the Wnt\/\u03b2-catenin signaling pathway in adrenocortical cells. In the present study, we have investigated whether \u03b2-catenin activation may also trigger the illegitimate expression of GIP and 5-HT receptors. Three models of \u03b2-catenin activation in adrenocortical cells were used: an\n                    <jats:italic>APC<\/jats:italic>\n                    -mutated adrenocortical tumor, human-transfected adrenocortical cells and genetically modified mouse adrenal glands. The methods employed include quantitative reverse transcription PCR, immunohistochemistry and measurement of cortisol secretion by cultured tumor cells. Abnormal expression of the GIP, 5-HT\n                    <jats:sub>7<\/jats:sub>\n                    and LH receptors was observed in the\n                    <jats:italic>APC<\/jats:italic>\n                    -mutated adrenocortical tumor tissue. In addition, GIP, 5-HT and human chorionic gonadotropin stimulated cortisol production from tumor cells in primary culture. Conversely, only the\n                    <jats:italic>LHCGR<\/jats:italic>\n                    was upregulated in human and mouse adrenocortical cells harboring the activation of \u03b2-catenin. Moreover, LH-R immunoreactivity was detected in clusters of zona fasciculata cells in the \u03b2-catenin-activated mouse model. Our data indicate that activation of the \u03b2-catenin signaling pathway can promote the illicit expression of functional LH-Rs in adrenal zona fasciculata cells but does not favor the abnormal expression of GIP and 5-HT receptors.\n                  <\/jats:p>","DOI":"10.1530\/erc-21-0298","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T09:28:56Z","timestamp":1640165336000},"page":"151-162","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":7,"title":["\u03b2-Catenin activation and illicit receptor expression in adrenocortical cells"],"prefix":"10.1530","volume":"29","author":[{"given":"Julie","family":"Le Mestre","sequence":"first","affiliation":[{"name":"1Normandie Univ., UNIROUEN, INSERM, U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u00ebl","family":"Thomas","sequence":"additional","affiliation":[{"name":"1Normandie Univ., UNIROUEN, INSERM, U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-6287","authenticated-orcid":true,"given":"C\u00e9line","family":"Duparc","sequence":"additional","affiliation":[{"name":"1Normandie Univ., UNIROUEN, INSERM, U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7648-5567","authenticated-orcid":true,"given":"Pierre","family":"Val","sequence":"additional","affiliation":[{"name":"2CNRS, UMR 6293, GReD, Inserm U1103, Universit\u00e9 Clermont Auvergne, Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Bures","sequence":"additional","affiliation":[{"name":"3Department of Diabetes, Endocrinology and Metabolic Diseases, Groupe Hospitalier du Havre, Montivilliers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Tuech","sequence":"additional","affiliation":[{"name":"4Department of Digestive Surgery, Rouen University Hospital, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Sabourin","sequence":"additional","affiliation":[{"name":"5Department of Pathology, Rouen University Hospital, Rouen, France"},{"name":"6Centre for Biological Resources, Rouen University Hospital, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Baert-Desurmont","sequence":"additional","affiliation":[{"name":"7Department of Genetics, Rouen University Hospital, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6181-9648","authenticated-orcid":true,"given":"Herv\u00e9","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"1Normandie Univ., UNIROUEN, INSERM, U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen, France"},{"name":"6Centre for Biological Resources, Rouen University Hospital, Rouen, France"},{"name":"8Department of Endocrinology, Diabetes and Metabolic Diseases, Rouen University Hospital, Rouen, France"},{"name":"9Clinical Investigation Centre, INSERM, CIC1404, Rouen University Hospital, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Louiset","sequence":"additional","affiliation":[{"name":"1Normandie Univ., UNIROUEN, INSERM, U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine-Related Cancer"],"original-title":[],"link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/29\/3\/ERC-21-0298.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/erc.bioscientifica.com\/downloadpdf\/journals\/erc\/29\/3\/ERC-21-0298.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:56:10Z","timestamp":1784555770000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/erc\/article\/29\/3\/151-162\/25616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/erc-21-0298","relation":{},"ISSN":["1351-0088","1479-6821"],"issn-type":[{"value":"1351-0088","type":"print"},{"value":"1479-6821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,1]]}}}