{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:48:44Z","timestamp":1787791724387,"version":"build-2784847793"},"reference-count":0,"publisher":"Bioscientifica","issue":"6","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:p>Among pituitary adenomas, prolactinomas are the most frequently diagnosed (about 50%). Dopamine agonists are generally effective in the treatment of prolactinomas. However, a subset of about 25% of patients does not respond to these agents. The management of drug-resistant prolactinomas remains a challenge for endocrinologists and new inhibitory treatments are needed. Pituitary activins inhibit lactotroph function. Its expression and action were found reduced in animal models of lactotroph hyperplasia (female mice overexpressing the B subunit of the human chorionic gonadotrophin and female mice knockout for dopamine receptor type 2). In these models, an oophorectomy avoids prolactinoma development. Hormonal replacement with oestradiol and\/or progesterone is not enough to reach the tumor size observed in transgenic females. We postulated that the loss of gonadal inhibins after an oophorectomy contributes to prevent hyperplasia development. Here, we demonstrated that an oophorectomy at 2 months age recovers the following in adulthood: (i) pituitary activin expression, (ii) activin receptor expression specifically in lactotroph population, (iii) activin biological activity in lactotrophs with a concomitant reduction of Pit-1 expression. To summarize, when an oophorectomy is performed, inhibins are lost and the inhibitory action of pituitary activins on lactotroph population is recovered, helping to prevent lactotroph hyperplasia development. These results emphasize the importance of the inhibitory action of activins on lactotroph function, positioning activins as a good therapeutic target for the treatment of resistant prolactinomas.<\/jats:p>","DOI":"10.1530\/erc-21-0397","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T07:52:15Z","timestamp":1648194735000},"page":"359-373","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":3,"title":["Oophorectomy improves pituitary activin inhibitory function preventing lactotroph hyperplasia development"],"prefix":"10.1530","volume":"29","author":[{"given":"Milagros","family":"Pe\u00f1a-Zanoni","sequence":"first","affiliation":[{"name":"1Instituto de Biolog\u00eda y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Yanil","family":"Faraoni","sequence":"additional","affiliation":[{"name":"1Instituto de Biolog\u00eda y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Abeledo-Machado","sequence":"additional","affiliation":[{"name":"1Instituto de Biolog\u00eda y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6751-2778","authenticated-orcid":true,"given":"Pablo Anibal","family":"Perez","sequence":"additional","affiliation":[{"name":"2Centro de Microscopia Electr\u00f3nica, Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Agustina","family":"Marcial L\u00f3pez","sequence":"additional","affiliation":[{"name":"1Instituto de Biolog\u00eda y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Andrea","family":"Camilletti","sequence":"additional","affiliation":[{"name":"1Instituto de Biolog\u00eda y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0509-5144","authenticated-orcid":true,"given":"Silvina","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"2Centro de Microscopia Electr\u00f3nica, Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8833-3309","authenticated-orcid":true,"given":"Susana B","family":"Rulli","sequence":"additional","affiliation":[{"name":"1Instituto de Biolog\u00eda y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7373-6893","authenticated-orcid":true,"given":"Graciela","family":"Diaz-Torga","sequence":"additional","affiliation":[{"name":"1Instituto de Biolog\u00eda y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine-Related Cancer"],"original-title":[],"link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/29\/6\/ERC-21-0397.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/erc.bioscientifica.com\/downloadpdf\/journals\/erc\/29\/6\/ERC-21-0397.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:56:13Z","timestamp":1784555773000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/erc\/article\/29\/6\/359-373\/25688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1530\/erc-21-0397","relation":{},"ISSN":["1351-0088","1479-6821"],"issn-type":[{"value":"1351-0088","type":"print"},{"value":"1479-6821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,1]]}}}