{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:04:20Z","timestamp":1787313860741,"version":"build-2736575974"},"reference-count":0,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.en_GB"}],"content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>This guideline is written as a reference document for clinicians presented with the challenge of managing paediatric patients with differentiated thyroid carcinoma up to the age of 19 years. Care of paediatric patients with differentiated thyroid carcinoma differs in key aspects from that of adults, and there have been several recent developments in the care pathways for this condition; this guideline has sought to identify and attend to these areas. It addresses the presentation, clinical assessment, diagnosis, management (both surgical and medical), genetic counselling, follow-up and prognosis of affected patients. The guideline development group formed of a multi-disciplinary panel of sub-speciality experts carried out a systematic primary literature review and Delphi consensus exercise. The guideline was developed in accordance with The Appraisal of Guidelines Research and Evaluation Instrument II criteria, with input from stakeholders including charities and patient groups. Based on scientific evidence and expert opinion, 58 recommendations have been collected to produce a clear, pragmatic set of management guidelines. It is intended as an evidence base for future optimal management and to improve the quality of clinical care of Paediatric patients with differentiated thyroid carcinoma.<\/jats:p>","DOI":"10.1530\/erc-22-0035","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T09:23:37Z","timestamp":1656062617000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":16,"title":["Paediatric differentiated thyroid carcinoma: a UK National Clinical Practice Consensus Guideline"],"prefix":"10.1530","author":[{"given":"Sasha R","family":"Howard","sequence":"first","affiliation":[{"name":"S Howard , Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Freeston","sequence":"additional","affiliation":[{"name":"S Freeston, Whipps Cross Hospital, Barts Health NHS Trust, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barney","family":"Harrison","sequence":"additional","affiliation":[{"name":"B Harrison, n\/a, Retired , Sheffield, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Izatt","sequence":"additional","affiliation":[{"name":"L Izatt, Department of Clinical and Cancer Genetics, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali","family":"Natu","sequence":"additional","affiliation":[{"name":"S Natu, Department of Pathology, North Tees and Hartlepool NHS Foundation Trust, Hartlepool, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Newbold","sequence":"additional","affiliation":[{"name":"K Newbold, Clinical Oncology, Royal Marsden NHS Foundation Trust, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Pomplun","sequence":"additional","affiliation":[{"name":"S Pomplun, Pathology, University College London Hospitals NHS Foundation Trust, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen A","family":"Spoudeas","sequence":"additional","affiliation":[{"name":"H Spoudeas, Paediatric Endocrinology , Great Ormond Street Hospital For Children NHS Foundation Trust, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Wilne","sequence":"additional","affiliation":[{"name":"S Wilne, Paediatric Oncology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom R","family":"Kurzawinski","sequence":"additional","affiliation":[{"name":"T Kurzawinski, Endocrine Surgery, University College London Hospitals NHS Foundation Trust, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark N","family":"Gaze","sequence":"additional","affiliation":[{"name":"M Gaze, Clinical Oncology, University College London Hospitals NHS Foundation Trust, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine-Related Cancer"],"original-title":[],"link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/aop\/erc-22-0035\/erc-22-0035.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/erc.bioscientifica.com\/downloadpdf\/journals\/erc\/aop\/erc-22-0035\/erc-22-0035.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/erc.bioscientifica.com\/downloadpdf\/journals\/erc\/aop\/erc-22-0035\/erc-22-0035.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:56:14Z","timestamp":1784555774000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/erc\/article\/29\/11\/G1-G33\/25591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1530\/erc-22-0035","relation":{},"ISSN":["1351-0088","1479-6821"],"issn-type":[{"value":"1351-0088","type":"print"},{"value":"1479-6821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]}}}