{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:20:56Z","timestamp":1784557256938,"version":"3.55.0"},"reference-count":35,"publisher":"Bioscientifica","issue":"12","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:p>\n                    Corticotroph tumor progression after bilateral adrenalectomy\/Nelson\u2019s syndrome (CTP-BADX\/NS) is a severe complication of bilateral adrenalectomy (BADX). The aim of our study was to investigate the prevalence, presentation and outcome of CTP-BADX\/NS in patients with Cushing\u2019s disease (CD) included in the European Registry on Cushing\u2019s Syndrome (ERCUSYN). We examined data on 1045 CD patients and identified 85 (8%) who underwent BADX. Of these, 73 (86%) had follow-up data available. The median duration of follow-up since BADX to the last visit\/death was 7 years (IQR 2\u20139 years). Thirty-three patients (45%) experienced CTP-BADX\/NS after 3 years (1.5\u20136) since BADX. Cumulative progression-free survival was 73% at 3 years, 66% at 5 years and 46% at 10 years. CTP-BADX\/NS patients more frequently had a visible tumor at diagnosis of CD than patients without CTP-BADX\/NS (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). Twenty-seven CTP-BADX\/NS patients underwent surgery, 48% radiotherapy and 27% received medical therapy. The median time since diagnosis of CTP-BADX\/NS to the last follow-up visit was 2 years (IQR, 1\u20135). Control of tumor progression was not achieved in 16 of 33 (48%) patients, of whom 8 (50%) died after a mean of 4 years. Maximum adenoma size at diagnosis of CD was associated with further tumor growth in CTP-BADX\/NS despite treatment (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.033). Diagnosis of CTP-BADX\/NS, older age, greater UFC levels at diagnosis of CD and initial treatment predicted mortality. In conclusion, CTP-BADX\/NS was reported in 45% of the ERCUSYN patients who underwent BADX, and control of tumor growth was reached in half of them. Future studies are needed to establish effective strategies for prevention and treatment.\n                  <\/jats:p>","DOI":"10.1530\/erc-22-0074","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T12:42:08Z","timestamp":1664973728000},"page":"681-691","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":8,"title":["Corticotroph tumor progression after bilateral adrenalectomy: data from ERCUSYN"],"prefix":"10.1530","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3864-0105","authenticated-orcid":true,"given":"Elena","family":"Valassi","sequence":"first","affiliation":[{"name":"IIB-Sant Pau and Department of Endocrinology\/Medicine, Hospital Sant Pau and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER-ER, Unidad 747), ISCIII, Barcelona, Spain"},{"name":"Universitat Internacional de Catalunya (UIC), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Castinetti","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Aix Marseille University, AP-HM, INSERM, Marseille Medical Genetics, Marmara Institute, La Conception Hospital, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Ferriere","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Nutrition, University of Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stylianos","family":"Tsagarakis","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Evangelismos Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A","family":"Feelders","sequence":"additional","affiliation":[{"name":"Erasmus Medical Center, Division of Endocrinology, Department of Internal Medicine, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romana T","family":"Netea-Maier","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Droste","sequence":"additional","affiliation":[{"name":"Praxis f\u00fcr Endokrinologie Dr. med. Michael Droste, Oldenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian J","family":"Strasburger","sequence":"additional","affiliation":[{"name":"Division of Clinical Endocrinology, Department of Medicine CCM, Charit\u00e9-Universit\u00e4tsmedizin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Maiter","sequence":"additional","affiliation":[{"name":"Service d\u2019Endocrinologie et Nutrition, Cliniques universitaires Saint Luc, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darko","family":"Kastelan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospital Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chanson","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1185, Le Kremlin, Bic\u00eatre, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M","family":"Webb","sequence":"additional","affiliation":[{"name":"IIB-Sant Pau and Department of Endocrinology\/Medicine, Hospital Sant Pau and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER-ER, Unidad 747), ISCIII, Barcelona, Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona (UAB), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Demtr\u00f6der","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Endokrinologie, Diabetologie, Rheumatologie Dr. Demtr\u00f6der & Kollegen, Dortmund, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdis","family":"Pirags","sequence":"additional","affiliation":[{"name":"Paula Stradi\u0146a kl\u012bnisk\u0101 universit\u0101tes slimn\u012bca, Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Chabre","sequence":"additional","affiliation":[{"name":"Hospitalier Universitaire, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Franz","sequence":"additional","affiliation":[{"name":"Lohmann & Birkner Health Care Consultimg GmbH, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Santos","sequence":"additional","affiliation":[{"name":"IIB-Sant Pau and Department of Endocrinology\/Medicine, Hospital Sant Pau and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER-ER, Unidad 747), ISCIII, Barcelona, Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona (UAB), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[{"name":"Medizinische Klinik UND Poliklinik IV, Campus Innestadt, Klinikum der Universit\u00e4t M\u00fcnchen, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Endocrine Practice","doi-asserted-by":"publisher","first-page":"466","DOI":"10.4158\/EP15922.RA","article-title":"Predictors of biochemical remission and recurrence after surgical and radiation treatments of Cushing\u2019s disease: a systematic review and meta-analysis","volume":"22","author":"Abu Dabrh","year":"2016","unstructured":"Abu Dabrh AMSingh Ospina NMAl Nofal AFarah WHBarrionuevo PSarigianni MMohabbat ABBenkhadra KCarranza Leon BGGionfriddo MR2016Predictors of biochemical remission and recurrence after surgical and radiation treatments of Cushing\u2019s disease: a systematic review and meta-analysis. Endocrine Practice22466\u2013475. (https:\/\/doi.org\/10.4158\/EP15922.RA)10.4158\/EP15922.RA"},{"key":"bib2","series-title":"European Journal of Endocrinology","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1530\/EJE-12-0921","article-title":"Long-term remission and recurrence rates in Cushing\u2019s disease: predictive factors in a single-centre study","volume":"168","author":"Alexandraki","year":"2013","unstructured":"Alexandraki KIKaltsas GAIsidori AMStorr HLAfshar FSabin IAkker SAChew SLDrake WMMonson JP2013Long-term remission and recurrence rates in Cushing\u2019s disease: predictive factors in a single-centre study. European Journal of Endocrinology168639\u2013648. (https:\/\/doi.org\/10.1530\/EJE-12-0921)10.1530\/EJE-12-0921"},{"key":"bib3","series-title":"Journal of Clinical Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1210\/jc.2006-1328","article-title":"Corticotroph tumor progression after adrenalectomy in Cushing\u2019s disease: a reappraisal of Nelson\u2019s syndrome","volume":"92","author":"Assi\u00e9","year":"2007","unstructured":"Assi\u00e9 GBahurel HCoste JSilvera SKujas MDurgue MAKarray FDousset BBertherat JLegmann P2007Corticotroph tumor progression after adrenalectomy in Cushing\u2019s disease: a reappraisal of Nelson\u2019s syndrome. Journal of Clinical Endocrinology and Metabolism92172\u2013179. (https:\/\/doi.org\/10.1210\/jc.2006-1328)10.1210\/jc.2006-1328"},{"key":"bib4","series-title":"Clinical Endocrinology","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/j.1365-2265.1983.tb03215.x","article-title":"Comparison of preoperative and postoperative ACTH concentrations after bilateral adrenalectomy in Cushing\u2019s disease","volume":"18","author":"Barnett","year":"1983","unstructured":"Barnett AHLiversey JHFriday KDonald RAEspiner EA1983Comparison of preoperative and postoperative ACTH concentrations after bilateral adrenalectomy in Cushing\u2019s disease. Clinical Endocrinology18301\u2013305. (https:\/\/doi.org\/10.1111\/j.1365-2265.1983.tb03215.x)10.1111\/j.1365-2265.1983.tb03215.x"},{"key":"bib5","series-title":"Endocrine","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/s12020-020-02432-z","article-title":"Recurrence after pituitary surgery in adult Cushing\u2019s disease: a systematic review on diagnosis and treatment","volume":"70","author":"Braun","year":"2020","unstructured":"Braun LTRubinstein GZopp SVogel FSchmid-Tanwald CEscudero MPHonegger JLadurner RReincke M2020Recurrence after pituitary surgery in adult Cushing\u2019s disease: a systematic review on diagnosis and treatment. Endocrine70218\u2013231. (https:\/\/doi.org\/10.1007\/s12020-020-02432-z)10.1007\/s12020-020-02432-z"},{"key":"bib6","series-title":"Lancet: Diabetes and Endocrinology","first-page":"569","article-title":"Mortality in patients with Cushing\u2019s disease more than 10 years after remission: a multicentre, multinational, retrospective cohort study","volume":"4","author":"Clayton","year":"2016","unstructured":"Clayton RNJones PWReulen RCStewart PMHassan-Smith ZKNtali GKaravitaki NDekkers OMPereira AMBolland M2016Mortality in patients with Cushing\u2019s disease more than 10 years after remission: a multicentre, multinational, retrospective cohort study. Lancet: Diabetes and Endocrinology4569\u2013576. (https:\/\/doi.org\/10.1016\/S2213-8587(1630005-5)"},{"key":"bib7","series-title":"Lancet: Diabetes and Endocrinology","first-page":"847","article-title":"Consensus on diagnosis and management of Cushing\u2019s disease: a guideline update","volume":"9","author":"Fleseriu","year":"2021","unstructured":"Fleseriu MAuchus RBancos IBen-Shlomo ABertherart JBiermasz NRBoguszewski CLBronstein MDBuchfelder MCarmichael JD2021Consensus on diagnosis and management of Cushing\u2019s disease: a guideline update. Lancet: Diabetes and Endocrinology9847\u2013875. (https:\/\/doi.org\/10.1016\/S2213-8587(2100235-7)"},{"key":"bib8","series-title":"Endocrinology and Metabolism Clinics of North America","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.ecl.2020.05.004","article-title":"Nelson\u2019s syndrome: an update","volume":"49","author":"Fountas","year":"2020","unstructured":"Fountas AKaravitaki N2020Nelson\u2019s syndrome: an update. Endocrinology and Metabolism Clinics of North America49413\u2013432. (https:\/\/doi.org\/10.1016\/j.ecl.2020.05.004)10.1016\/j.ecl.2020.05.004"},{"key":"bib9","series-title":"Journal of Clinical Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1210\/clinem\/dgz200","article-title":"Outcomes of patients with Nelson\u2019s syndrome after primary treatment: a multicenter study from 13 UK Pituitary Centers","volume":"105","author":"Fountas","year":"2020","unstructured":"Fountas ALim ESDrake WMPowlson ASGurnell MMartin NMSeejore KMurray RDMacFarlane JAhluwalia R2020Outcomes of patients with Nelson\u2019s syndrome after primary treatment: a multicenter study from 13 UK Pituitary Centers. Journal of Clinical Endocrinology and Metabolism1051527\u20131537. (https:\/\/doi.org\/10.1210\/clinem\/dgz200)10.1210\/clinem\/dgz200"},{"key":"bib10","series-title":"Surgery","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.surg.2006.12.003","article-title":"Nelson\u2019s syndrome after bilateral adrenalectomy for Cushing\u2019s disease","volume":"141","author":"Gil-Cardenas","year":"2007","unstructured":"Gil-Cardenas AHerrera MFD\u00edaz-Polanco ARios JMPantoja JP2007Nelson\u2019s syndrome after bilateral adrenalectomy for Cushing\u2019s disease. Surgery141147\u2013151; discussion 151. (https:\/\/doi.org\/10.1016\/j.surg.2006.12.003)10.1016\/j.surg.2006.12.003"},{"key":"bib11","series-title":"Journal of Neurosurgery","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.3171\/2016.9.JNS161163","article-title":"Characterizing and oredicting the Nelson-Salassa syndrome","volume":"127","author":"Graffeo","year":"2017","unstructured":"Graffeo CSPerry ACarlstrom LPMeyer FBAtkinson JLDErickson DNippolst TBYoung WFJrPollock BEvan Gompel JJ2017Characterizing and oredicting the Nelson-Salassa syndrome. Journal of Neurosurgery1271277\u20131287. (https:\/\/doi.org\/10.3171\/2016.9.JNS161163)10.3171\/2016.9.JNS161163"},{"key":"bib12","series-title":"Journal of the Endocrine Society","first-page":"144","article-title":"The molecular pathology of Cushing\u2019s disease: are we nearly there?","volume":"1","author":"Grossman","year":"2017","unstructured":"Grossman AB2017The molecular pathology of Cushing\u2019s disease: are we nearly there?Journal of the Endocrine Society1144\u2013148. (https:\/\/doi.org\/10.1210\/js.2017-00036)"},{"key":"bib13","series-title":"Lancet: Diabetes and Endocrinology","first-page":"581","article-title":"Risk of second brain tumour after radiotherapy for pituitary adenoma or craniopharyngioma: a retrospective, multicentre, cohort study of 3679 patients with long-term imaging surveillance","volume":"10","author":"Hamblin","year":"2022","unstructured":"Hamblin RVardon AAkpalu JTampourlou MSpilotis ISbardella ELynch JShankaran VMavilakaandy AGagliardi I2022Risk of second brain tumour after radiotherapy for pituitary adenoma or craniopharyngioma: a retrospective, multicentre, cohort study of 3679 patients with long-term imaging surveillance. Lancet: Diabetes and Endocrinology10581\u2013588. (https:\/\/doi.org\/10.1016\/S2213-8587(2200160-7)"},{"key":"bib14","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"165","article-title":"The long-term outcome after adrenalectomy and prophylactic pituitary radiotherapy in adrenocorticitropin-dependent Cushing\u2019s syndrome","volume":"80","author":"Jenkins","year":"1995","unstructured":"Jenkins PJTrainer PJPlowman PNShand WSGrossmann ABWass JABresser GM1995The long-term outcome after adrenalectomy and prophylactic pituitary radiotherapy in adrenocorticitropin-dependent Cushing\u2019s syndrome. Journal of Clinical Endocrinology and Metabolism80165\u2013171. (https:\/\/doi.org\/10.1210\/jcem.80.1.7829606)"},{"key":"bib15","series-title":"Zentralblatt f\u00fcr Neurochirurgie","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1055\/s-2006-921430","article-title":"Nelson\u2019s syndrome-46 years later: clinical experience with 37 patients","volume":"67","author":"Kasperlik-Zaluska","year":"2006","unstructured":"Kasperlik-Zaluska AABonicki WJeske WJanik JZgliczynski WCzernicki Z2006Nelson\u2019s syndrome-46 years later: clinical experience with 37 patients. Zentralblatt f\u00fcr Neurochirurgie6714\u201320. (https:\/\/doi.org\/10.1055\/s-2006-921430)10.1055\/s-2006-921430"},{"key":"bib16","series-title":"Clinical Endocrinology","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1111\/j.1365-2265.1983.tb00046.x","article-title":"Nelson\u2019s syndrome: incidence and prognosis","volume":"19","author":"Kasperlik-Zaluska","year":"1983","unstructured":"Kasperlik-Zaluska AANelubowicz JWislawski JHartwig WZaluska JJeske WMigdalska B1983Nelson\u2019s syndrome: incidence and prognosis. Clinical Endocrinology19693\u2013698. (https:\/\/doi.org\/10.1111\/j.1365-2265.1983.tb00046.x)10.1111\/j.1365-2265.1983.tb00046.x"},{"key":"bib17","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"887","article-title":"Patient\u2019s age is a simple predictive factor for the development of Nelson\u2019s syndrome after total adrenalectomy for Cushing\u2019s disease","volume":"79","author":"Kemink","year":"1994","unstructured":"Kemink LPieters GHermus ASmals AKloppenborg P1994Patient\u2019s age is a simple predictive factor for the development of Nelson\u2019s syndrome after total adrenalectomy for Cushing\u2019s disease. Journal of Clinical Endocrinology and Metabolism79887\u2013889. (https:\/\/doi.org\/10.1210\/jcem.79.3.8077377)"},{"key":"bib18","series-title":"Journal of Clinical Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1210\/jc.2012-2893","article-title":"Predictors of mortality and long-term outcomes in treated Cushing\u2019s disease: a study of 346 patients","volume":"98","author":"Lambert","year":"2013","unstructured":"Lambert JKGoldberg LFayngold SKostadinov JPost KDGeer EB2013Predictors of mortality and long-term outcomes in treated Cushing\u2019s disease: a study of 346 patients. Journal of Clinical Endocrinology and Metabolism981022\u20131030. (https:\/\/doi.org\/10.1210\/jc.2012-2893)10.1210\/jc.2012-2893"},{"key":"bib19","series-title":"Clinical Endocrinology","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/j.1365-2265.1990.tb03883.x","article-title":"Long-term follow-up of low-dose external pituitary irradiation for Cushing\u2019s disease","volume":"33","author":"Littley","year":"1990","unstructured":"Littley MDShalet SMBeardwell CGAhmed SRSutton ML1990Long-term follow-up of low-dose external pituitary irradiation for Cushing\u2019s disease. Clinical Endocrinology33445\u2013455. (doi:10.1111\/j.1365-2265.1990.tb03883.x.)10.1111\/j.1365-2265.1990.tb03883.x"},{"key":"bib20","series-title":"Clinical Endocrinology","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/j.1365-2265.1993.tb02371.x","article-title":"Bilateral adrenalectomy: low mortality and morbidity in Cushing\u2019s disease","volume":"39","author":"McCance","year":"1993","unstructured":"McCance DRRussell CFKennedy TLHadden DRKennedy LAtkinson AB1993Bilateral adrenalectomy: low mortality and morbidity in Cushing\u2019s disease. Clinical Endocrinology39315\u2013321. (https:\/\/doi.org\/10.1111\/j.1365-2265.1993.tb02371.x)10.1111\/j.1365-2265.1993.tb02371.x"},{"key":"bib21","series-title":"Journal of the Association of Physicians of India","first-page":"304","article-title":"Incidence of Nelson\u2019s syndrome and residual adrenocortical function in patients with Cushing\u2019s disease after bilateral adrenalectomy","volume":"42","author":"Misra","year":"1994","unstructured":"Misra DKapur MMGupta DK1994Incidence of Nelson\u2019s syndrome and residual adrenocortical function in patients with Cushing\u2019s disease after bilateral adrenalectomy. Journal of the Association of Physicians of India42304\u2013305."},{"key":"bib22","series-title":"World Journal of Surgery","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s002689910020","article-title":"Long-term results of total adrenalectomy for Cushing\u2019s disease","volume":"24","author":"Nagesser","year":"2000","unstructured":"Nagesser SKvan Seters APKievit JHermans JKrans HMvan de Velde CJ2000Long-term results of total adrenalectomy for Cushing\u2019s disease. World Journal of Surgery24108\u2013113. (doi:10.1007\/s002689910020.)10.1007\/s002689910020"},{"key":"bib23","series-title":"Journal of Clinical Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1210\/jc.2015-1818","article-title":"Treatment of Cushing\u2019s syndrome: an Endocrine Society clinical practice guideline","volume":"100","author":"Nieman","year":"2015","unstructured":"Nieman LKBiller BMFindling JWMurad MHNewell-Price JSavage MOTabarin A & Endocrine Society2015Treatment of Cushing\u2019s syndrome: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism1002807\u20132831. (https:\/\/doi.org\/10.1210\/jc.2015-1818)10.1210\/jc.2015-1818"},{"key":"bib24","series-title":"European Journal of Endocrinology","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1530\/EJE-14-0214","article-title":"Favorable long-term outcomes of bilateral adrenalectomy in Cushing\u2019s disease","volume":"171","author":"O\u00dfwald","year":"2014","unstructured":"O\u00dfwald APlomer EDimopoulou CMilian MBlaser RRitzel KMickisch AKnerr FStanojevic MHallfeldt K2014Favorable long-term outcomes of bilateral adrenalectomy in Cushing\u2019s disease. European Journal of Endocrinology171209\u2013215. (https:\/\/doi.org\/10.1530\/EJE-14-0214)10.1530\/EJE-14-0214"},{"key":"bib25","series-title":"Clinical Endocrinology","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1046\/j.1365-2265.1998.00578.x","article-title":"A study of patients with Nelson\u2019s syndrome","volume":"49","author":"Pereira","year":"1998","unstructured":"Pereira MAHalpern ASalgado LRMendonca BBNery MLiberman BStreeten DHWajchenberg BL1998A study of patients with Nelson\u2019s syndrome. Clinical Endocrinology49533\u2013539. (doi:10.1046\/j.1365-2265.1998.00578.x.)10.1046\/j.1365-2265.1998.00578.x"},{"key":"bib26","series-title":"European Journal of Endocrinology","doi-asserted-by":"publisher","first-page":"R227","DOI":"10.1530\/EJE-14-0883","article-title":"Therapy of endocrine disease: outcomes in patients with Cushing\u2019s disease undergoing transsphenoidal surgery: systematic review assessing criteria used to define remission and recirrence","volume":"172","author":"Petersenn","year":"2015","unstructured":"Petersenn SBeckers AFerone Dvan der Lely ABollerslev JBoscaro MBrue TBruzzi PCasanueva FFChanson P2015Therapy of endocrine disease: outcomes in patients with Cushing\u2019s disease undergoing transsphenoidal surgery: systematic review assessing criteria used to define remission and recirrence. European Journal of Endocrinology172R227\u2013R239. (https:\/\/doi.org\/10.1530\/EJE-14-0883)10.1530\/EJE-14-0883"},{"key":"bib27","series-title":"Journal of Clinical Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1210\/jc.2018-02524","article-title":"Overall and disease-specific mortality in patients with Cushing\u2019s disease: a Swedish Nationwide Study","volume":"104","author":"Ragnarsson","year":"2019","unstructured":"Ragnarsson OOlsson DSPapakokkinou EChantzichristos DDahlqvist PSegerstedt EOlsson TPetersson MBerinder KBensing S2019Overall and disease-specific mortality in patients with Cushing\u2019s disease: a Swedish Nationwide Study. Journal of Clinical Endocrinology and Metabolism1042375\u20132384. (https:\/\/doi.org\/10.1007\/s11102-021-01158-z)10.1210\/jc.2018-02524"},{"key":"bib28","series-title":"European Journal of Endocrinology","doi-asserted-by":"publisher","first-page":"P1","DOI":"10.1530\/EJE-20-1088","article-title":"Corticotroph tumor progression after bilateral adrenalectomy (Nelson\u2019s syndrome): systematic review and expert consensus recommendations","volume":"184","author":"Reincke","year":"2021","unstructured":"Reincke MAlbani AAssi\u00e9 GBancos IBrue TBuchfelder MChabre OCeccato FDaniele ADetomas M2021Corticotroph tumor progression after bilateral adrenalectomy (Nelson\u2019s syndrome): systematic review and expert consensus recommendations. European Journal of Endocrinology184P1\u2013P16. (https:\/\/doi.org\/10.1530\/EJE-20-1088)10.1530\/EJE-20-1088"},{"key":"bib29","series-title":"Journal of Clinical Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"3939","DOI":"10.1210\/jc.2013-1470","article-title":"Clinical review: Outcome of bilateral adrenalectomy in Cushing\u2019s syndrome: a systematic review","volume":"98","author":"Ritzel","year":"2013","unstructured":"Ritzel KBeuschlein FMickisch AO\u00dfwald ASchneider HJSchopohl JReincke M2013Clinical review: Outcome of bilateral adrenalectomy in Cushing\u2019s syndrome: a systematic review. Journal of Clinical Endocrinology and Metabolism983939\u20133948. (https:\/\/doi.org\/10.1210\/jc.2013-1470)10.1210\/jc.2013-1470"},{"key":"bib30","series-title":"Pituitary","first-page":"524","article-title":"Clinical factors involved in the recurrence of pituitary adenomas after surgical remission: a structured review and meta-analysis","volume":"21","author":"Roelfsema","year":"2018","unstructured":"Roelfsema FBiermasz NRPereira AM2018Clinical factors involved in the recurrence of pituitary adenomas after surgical remission: a structured review and meta-analysis. Pituitary21524\u2013534. (https:\/\/doi.org\/10.1007\/s11102-011-0347-7)"},{"key":"bib31","series-title":"Endocrine Pathology","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s12022-010-9138-3","article-title":"Low immunohistochemical expression of MGMT in ACTH secreting pituitary tumors of patients with Nelson\u2019s syndrome","volume":"21","author":"Salehi","year":"2010","unstructured":"Salehi FScheithauer BWMoyes VJDrake WMSyro LVManoranjan BSharma SHorvath EKovacs K2010Low immunohistochemical expression of MGMT in ACTH secreting pituitary tumors of patients with Nelson\u2019s syndrome. Endocrine Pathology21227\u2013229. (https:\/\/doi.org\/10.1007\/s12022-010-9138-3)10.1007\/s12022-010-9138-3"},{"key":"bib32","series-title":"Journal of the American College of Surgeons","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.jamcollsurg.2009.02.054","article-title":"Bilateral adrenalectomy for refractory Cushing\u2019s disease: a safe and definitive therapy","volume":"208","author":"Smith","year":"2009","unstructured":"Smith PWTurza KCCarter COVance MLLaws ERHanka JB2009Bilateral adrenalectomy for refractory Cushing\u2019s disease: a safe and definitive therapy. Journal of the American College of Surgeons2081059\u20131064. (https:\/\/doi.org\/10.1016\/j.jamcollsurg.2009.02.054)10.1016\/j.jamcollsurg.2009.02.054"},{"key":"bib33","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"2647","article-title":"Risk factors and long-term outcome in pituitary-dependent Cushing\u2019s disease","volume":"81","author":"Sonino","year":"1996","unstructured":"Sonino NZielezny MFava GAFallo FBoscaro M1996Risk factors and long-term outcome in pituitary-dependent Cushing\u2019s disease. Journal of Clinical Endocrinology and Metabolism812647\u20132652. (doi:10.1210\/jcem.81.7.8675592.)"},{"key":"bib34","series-title":"Journal of Clinical Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1210\/jc.2009-1672","article-title":"Delayed remission after transsphenoidal surgery in patients with Cushing\u2019s disease","volume":"95","author":"Valassi","year":"2010","unstructured":"Valassi EBiller BMSwearingen BPecori Giraldi FLosa MMortini PHayden DCavagnini FKlibanski A2010Delayed remission after transsphenoidal surgery in patients with Cushing\u2019s disease. Journal of Clinical Endocrinology and Metabolism95601\u2013610. (https:\/\/doi.org\/10.1210\/jc.2009-1672)10.1210\/jc.2009-1672"},{"key":"bib35","series-title":"European Journal of Endocrinology","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1530\/EJE-11-0272","article-title":"The European Registry on Cushing\u2019s syndrome: a 2-year experience. Baseline demographic and clinical characteristics","volume":"165","author":"Valassi","year":"2011","unstructured":"Valassi ESantos AYaneva MToth MStrasburger CJChanson PWass JAHChabre OPfeifer MFeelders RA2011The European Registry on Cushing\u2019s syndrome: a 2-year experience. Baseline demographic and clinical characteristics. European Journal of Endocrinology165383\u2013392. (https:\/\/doi.org\/10.1530\/EJE-11-0272)10.1530\/EJE-11-0272"}],"container-title":["Endocrine-Related Cancer"],"original-title":[],"link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/29\/12\/ERC-22-0074.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/erc.bioscientifica.com\/downloadpdf\/journals\/erc\/29\/12\/ERC-22-0074.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/erc.bioscientifica.com\/downloadpdf\/journals\/erc\/29\/12\/ERC-22-0074.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:56:15Z","timestamp":1784555775000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/erc\/article\/29\/12\/681-691\/25590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":35,"journal-issue":{"issue":"12"},"URL":"https:\/\/doi.org\/10.1530\/erc-22-0074","relation":{},"ISSN":["1351-0088","1479-6821"],"issn-type":[{"value":"1351-0088","type":"print"},{"value":"1479-6821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,1]]}}}