{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:13:37Z","timestamp":1787022817189,"version":"build-2736575974"},"reference-count":48,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,12,12]]},"abstract":"<jats:p>\n                    The aim of this study is to characterise somatostatin analogue-responsive headache in acromegaly, hitherto not systematically documented in a significant cohort. Using the UK pituitary network, we have clinically characterised a cohort of 18 patients suffering from acromegaly-related headache with a clear response to somatostatin analogues. The majority of patients had chronic migraine (78%) as defined by the International Headache Society diagnostic criteria. Headache was present at the time of acromegaly presentation and clearly associated temporally with disease activity in all cases. Short-acting somatostatin analogues uniquely resolved pain within minutes and the mean duration of analgesia was 1\u20136 h. Patients on long-acting analogues required less short-acting injections (mean: 3.7 vs 10.4 injections per day,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.005). 94% used somatostatin analogues to control ongoing headache pain. All patients presented with macroadenoma, most had incomplete resection (94%) and headache was ipsilateral to remnant tissue (94%). Although biochemical control was achieved in 78% of patients, headache remained in 71% of them. Patients selected for this study had ongoing headache post-treatment (mean duration: 16 years after diagnosis); only four patients reached headache remission 26 years (mean range: 14\u201333) after the diagnosis. Headache in acromegaly patients can be persistent, severe, unrelieved by surgery, long-lasting and uncoupled from biochemical control. We show here that long-acting analogues allow a decrease in the number of short-acting analogue injections for headache relief. Further studies are needed to understand the mechanisms, markers and tumour tissue characteristics of acromegaly-related headache. Until then, this publication serves to provide the clinical characteristics as a reference point for further study.\n                  <\/jats:p>","DOI":"10.1530\/erc-22-0138","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T09:27:49Z","timestamp":1673515669000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":12,"title":["A study of acromegaly-associated headache with somatostatin analgesia"],"prefix":"10.1530","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6894-8648","authenticated-orcid":true,"given":"Sonia","family":"Kaniuka-Jakubowska","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland"},{"name":"Department of Endocrinology at the Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles J","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology at the Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayakshi","family":"Abeyaratne","sequence":"additional","affiliation":[{"name":"Department of Endocrinology at the Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"},{"name":"Diabetes and Endocrinology Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M","family":"Drake","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6414-5629","authenticated-orcid":true,"given":"Nikolaos","family":"Kyriakakis","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6730-6109","authenticated-orcid":true,"given":"Robert D","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve M","family":"Orme","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailesh","family":"Gohil","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Brooke","sequence":"additional","affiliation":[{"name":"MacLeod Diabetes and Endocrinology Centre, Royal Devon and Exeter Hospital, Exeter, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham P","family":"Leese","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, NHS Tayside, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rta","family":"Korbonits","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John AH","family":"Wass","sequence":"additional","affiliation":[{"name":"Department of Endocrinology at the Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Headache","first-page":"782","article-title":"Headache associated with pituitary adenomas","volume":"38","author":"Abe","year":"1998","unstructured":"Abe TMatsumoto KKuwazawa JToyoda ISasaki K 1998Headache associated with pituitary adenomas. Headache38782\u2013786. (https:\/\/doi.org\/10.1046\/j.1526-4610.1998.3810782.x)11279904"},{"key":"bib2","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"1789","article-title":"The dominant role of increased intrasellar pressure in the pathogenesis of hypopituitarism, hyperprolactinemia, and headaches in patients with pituitary adenomas","volume":"85","author":"Arafah","year":"2000","unstructured":"Arafah BMPrunty DYbarra JHlavin MLSelman WR 2000The dominant role of increased intrasellar pressure in the pathogenesis of hypopituitarism, hyperprolactinemia, and headaches in patients with pituitary adenomas. Journal of Clinical Endocrinology and Metabolism851789\u20131793. 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Headache2570\u201374. (https:\/\/doi.org\/10.1111\/j.1526-4610.1985.hed2502070.x)3921490"},{"key":"bib14","series-title":"Journal of Headache and Pain","first-page":"15","article-title":"Headache associated with pituitary tumors","volume":"10","author":"Gondim","year":"2009","unstructured":"Gondim JAde Almeida JPde Albuquerque LASchops MGomes EFerraz T 2009Headache associated with pituitary tumors. Journal of Headache and Pain1015\u201320. 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