{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:21:06Z","timestamp":1784557266609,"version":"3.55.0"},"reference-count":157,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1,4]]},"abstract":"<jats:p>Radiotherapy is one of the major options currently for cancer treatment. Radiotherapy causes cellular damage inducing cell death, which is expected to be selective for tumor cells. However, side effects that alter the surrounding normal tissue are often hard to be avoided. When radiation involves the hypothalamic\u2013pituitary axis, growth hormone deficiency (GHD) is frequently induced, causing developmental and metabolic-related diseases in childhood cancer survivors. Growth hormone (GH) replacement therapy has been used for these patients and has been shown to be safe in general. However, there are some debating for its long-term safety due to the known roles of GH in inducing cell growth, which could be related to cancer recurrence. In addition, studies have shown that GH is involved in the development of resistance to chemotherapy and radiotherapy through various mechanisms. In this review, we will first discuss the effects of GHD induced after radiotherapy and the safety of the GH replacement treatment. Then, we will discuss the role of the GH\u2013IGF-1 axis in radioresistance via a mechanism of improving DNA repair.<\/jats:p>","DOI":"10.1530\/erc-22-0371","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T09:19:04Z","timestamp":1704359944000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":4,"title":["Growth hormone and radiation therapy: friend, foe, or both?"],"prefix":"10.1530","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0488-2472","authenticated-orcid":true,"given":"Ver\u00f3nica A","family":"Bahamondes Lorca","sequence":"first","affiliation":[{"name":"Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA"},{"name":"Departamento de Tecnolog\u00eda M\u00e9dica, Facultad de Medicina, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4104-4160","authenticated-orcid":true,"given":"Shiyong","family":"Wu","sequence":"additional","affiliation":[{"name":"Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA"},{"name":"Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"British Journal of Cancer","first-page":"1600","article-title":"IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer","volume":"117","author":"Aleksic","year":"2017","unstructured":"Aleksic TVerrill CBryant RJHan CWorrall ARBrureau LLarr\u00e9 SHiggins GSFazal FSabbagh A, et al.2017IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer. 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